ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03321.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.The acute effects of fatty meals (900 kcal) rich in saturated (cream) or n‐3 polyunsaturated (cod liver oil, CLO) fatty acids on human umbilical vein endothelial cells (ECM) and platelet behavior were studied. The ECM were incubated for 24 hours at 37°C with either plasma or chylomicrons (CM) obtained 3 hours after the meals. The ability of the ECM to inhibit platelet aggregation (PIA) and the release of prostaglandin I2measured as 6‐ketoprostaglandin F1α(6‐keto‐PGF1α) were measured after 24 hours of incubation, after stimulation and after freezing and thawing. Similar studies were done with CM from a patient with type V hyperlipoproteinemia. The release of 6‐keto‐PGF1αwas increased by postprandial plasma and by CM obtained after both meals. Plasma collected after CLO, but not after cream, increased PIA, whereas CM derived from all sources studied stimulated the PIA of ECM. No consistent correlation could be established between the release of 6‐keto‐PGF1αand PIA. Increased platelet aggregation in platelet‐rich plasma was always observed during postp

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03322.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.A prospective randomized study was performed to investigate the long‐term sequelae of calf vein thrombosis (CVT) and correlate them to the success of the initial treatment. Thirty‐six patients with symptomatic CVT, verified by venography, were treated with heparin or low‐dose streptokinase (SK) combined with low‐dose heparin. Venography was repeated after 1 week, and long‐term follow‐up was performed clinically and with foot volumetry after an average of 5 years. Since the low‐dose SK regimen led to serious hemorrhagic side‐effects in a parallel study, the present investigation was discontinued prematurely. The thrombolysis achieved was greater with SK but, since the initial thrombi were somewhat larger in this group, no significant difference in the average size of the thrombi after therapy could be displayed between the groups. The long‐term sequelae and results of foot volumetry were also equal. Signs or symptoms of venous insufficiency were found in 37%, and foot volumetry showed deep venous insufficiency in 26% of the cases. There was a correlation between the hemodynamic change, as assessed by foot volumetry, and the venographic severity. This relation was stronger for the size of the thrombus after treatment than for the initial size. Thus, it seems important to limit the extent of a CVT in order to minimize the long‐term sequelae, but administration of SK is not justified

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03323.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Ninety‐two patients with suspected unilateral deep venous thrombosis (DVT) in the lower limb were examined by thermography, plethysmography and phlebography. ROC analysis (Receiver Operating Characteristics) was used to evaluate discrimination thresholds and to compare thermography and plethysmography (four variables) with phlebography. The sensitivity of thermography, 85% (94% for out‐patients), was higher than that of plethysmography (58–79%) for the discrimination thresholds chosen. The specificity of thermography was low, 39% (42% for out‐patients) or 55%, if obvious relevant clinical findings were included in the evaluation. The specificity of plethysmography was much higher (80–97%). Optimum combination of the four plethysmographic variables showed predictive values of 93–94%, while combination of thermography and plethysmographic variables showed higher predictive values (95–97%), mostly because of a higher sensitivity of thermography for distal DVT. A possible reduction of the number of phlebographic examinations by at least 50% and a cost reduction of 25% could have been obtained without any appreciable loss of diagnostic accuracy. A follow‐up study of 112 consecutive patients, examined according to the recommended screening method, showed a reduction of phlebographic exam

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03324.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Serum lipoproteins were analysed in 11 hypertensive patients before and after 2 and 16 months on pindolol therapy. In all patients significant blood pressure reductions were achieved with a mean pindolol dose of 13 mg (range 5–30) per day at 16 months' follow‐up. After 2 months a significant increase by 35% was found in VLDL TG and cholesterol concentrations, but after 16 months all lipoprotein values had reverted to pretreatment levels. HDL did not change during pindolol therapy. It is not established whether the lack of long‐term effects of pindolol on serum lipoprotein is specifically due to its high degree of intrinsic sympatomimetic act

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03325.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Eleven moderately obese middle‐aged male outpatients with untreated mild hypertension reduced their sodium intake by about 120 mmol per day during 4–6 weeks. Diastolic blood pressure was then significantly reduced in comparison with a matched control group. The reduction of urinary sodium excretion was significantly correlated to the change in mean arterial pressure. Mean body mass showed a small significant decrease, although there were no significant changes in total body water or body fat as determined from measurements of40K and tritiated water. Nor did mean extracellular water or plasma volume (Evan's blue) show any significant change. The decrease in urinary sodium excretion was associated with increases in plasma renin activity and urinary aldosterone excretion, while a sympathetic nervous natriuretic index (urinary dopamine to noradrenaline excretion ratio) decreased. The low sodium diet period was followed by a period of energy reduction as well as sodium restriction for 15 weeks. Mean body mass was then reduced by about 8 kg. The systolic but not the diastolic blood pressure showed a significant decrease. The intraerythrocyte content of water, sodium and potassium did not change significantly during any of the diet periods. We conclude that moderate sodium restriction lowered the blood pressure and affected the renin‐aldosterone and sympathetic nervous system to retain sodium which might explain the constancy of the plasma v

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03326.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.The antihypertensive and biochemical effects of 25 mg hydrochlorothiazide alone or 50 mg hydrochlorothiazide alone or in combination with triamterene (either 37.5 or 75 mg) once daily were studied in 26 patients with essential hypertension. After a 5‐week run‐in period the patients were randomized to receive active therapy in a cross‐over manner. Each treatment period lasted 3 months. All drugs significantly (p<0.01) lowered both systolic and diastolic blood pressure. There were no differences in blood pressure between the medication periods. Serum potassium concentration was slightly lower during all medication periods than during the run‐in period. This change was statistically significant (p<0.01) only on 50 mg hydrochlorothiazide daily. There were no significant changes in serum magnesium during any of the periods compared to the run‐in period. The lowest values were recorded on 50 mg hydrochlorothiazide alone and the highest on 50 mg hydrochlorothiazide plus 75 mg triamterene daily. A slight increase in serum urate was recorded in all medication periods compared to the run‐in period. No significant changes were observed in serum total cholesterol, HDL cholesterol or triglycerides between any of the periods. It can be concluded that 25 mg of hydrochlorothiazide is as effective in lowering blood pressure as higher doses of the diuretic. Higher doses of thiazides will in some patients cause adverse metabolic reactions of which the fall in serum potassium and magnesium is effectively hindered by

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03327.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Plasma concentrations of arginine vasopressin (AVP), angiotensin II (AII), aldosterone (Aldo), urinary output (V), osmolar clearance (Cosm), free water clearance (CH2O), fractional excretions of sodium (FENa) and potassium (FEK), urinary sodium excretion rate (U‐Na) and serum potassium (S‐K) were determined in 9 patients with essential hypertension (group I) and 13 normotensive healthy control subjects (group II) before and three times during the first 4 hours after an intravenous injection of 40 mg of furosemide. AVP, AII, Aldo, V, Cosm, FENa, FEKand U‐Na increased in both groups. However, the elevation in AVP was significantly more pronounced and the rate of increase in Aldo was significantly slower in group I than in group II. There were no significant differences in AII, V, Cosm, CH2O. FENa, FEKand U‐Na between the groups. S‐K was significantly reduced only in group I. AVP and AII were not significantly correlated to each other or to blood pressure. It is suggested that the responsiveness of the renal tubules to AVP is reduced in essential hypertension and that the larger increase in AVP might be a compensatory phenomenon. The slower increase in Aldo in essential hypertension could be attributed to the reducti

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03328.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Nonantral gastric carcinoid tumours in association with pronounced hypergastrinaemia are reported in 6 patients. It is suggested that the hypergastrinaemia, as a result of lack of a negative acid feedback inhibition in an achlorhydric stomach, promoted the tumour development, possibly initiated by action of carcinogenic nitrosamines, in the gastric juice.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03329.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

ABSTRACT.Blood volume (BV), extracellular volume (ECV), blood pressure (BP), creatinine clearance (CCr), plasma levels of angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP), and serum osmolality (Sosm) were determined in 18 patients with adult polycystic kidney disease, 8 normotensive (group I), 10 hypertensive (group II), and in 11 control subjects (group III). ECV but not BV was increased in group I compared with group III, whereas BV and ECV did not differ significantly between groups II and III. In group II, Aldo and AVP were increased and AII tended to be increased, while in group I the hormone levels did not differ significantly from those in group III. Sosmdid not differ significantly between the groups. In the combined patient group, CCrcorrelated positively with BV and ECV and negatively with BP. In the patients, AII and AVP were positively correlated with BP but not with CCr. The results suggest that both the renin‐angiotensin system and AVP might be involved in the BP elevation, whereas expansion of ECV can be found without an increase in B

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1986.tb03330.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY