ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08084.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08085.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Three Danish pedigrees have been studied with a view to reduced thyroxine‐binding globulin (TBG). The study confirmed that this defect is transmitted by X‐chromosome‐linked dominant inheritance, there being no man‐to‐man transmission, but also that it may occur in two types: deficient TBG and low, non‐zero TBG. Definite changes of TBG and thyroid function tests were found in the hemizygous men, whereas the heterozygous women showed a marked variation in the range between the values for hemizygous men and normal persons. Determination of total thyroxine appears to afford more guidance than the protein‐bound iodine suggested by others. Two of four women on oral contraception exhibited such deviating TBG values that they are assumed to be TBG heterozygous. In all persons free thyroxine proved normal or slightly reduced but all the persons tested were euthyroid. However, the propositus of one family had previously been treated for Gr

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08086.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The purpose of the present work was to compare the reliability of the new in vitro thyroid test, ETR, with that of the other commonly used thyroid tests in three different ways. 1. Comparison of the test results with the clinical picture obtained by a doctor on the basis of anamnesis and status. 2. Investigation of the correlation of ETR with the other thyroid tests. 3. Investigation of the ability of the tests to discriminate between states of hypo‐, hyper‐ and euthyroidism. The material examined consisted of 62 patients. The results showed ETR to be the best of the laboratory tests according to all three criteria. ETR correlated with the clinical picture obtained on the basis of anamnesis and status in 95% of the cases. ETR correlated highly significantly with the other thyroid tests used (T4T3(= T3uptake), FT4index, PBI, cholesterol and radioiodine test). The discriminative capacity of ETR was highly significant in all the states, while the ability of the T3test to distinguish hypothyroidism was not statistically signific

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08087.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08088.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Eight patients with previously untreated hereditary, hypothalamic diabetes insipidus have been investigated. Infusion of hypertonic saline produced no significant antidiuresis in any of seven patients tested. In two, however, urine osmolality increased to values exceeding plasma osmolality. During water deprivation (818 h) urine osmolality increased in all patients, but only in three were values exceeding plasma osmolality reached. Administration of a new, long‐acting analogue of vasopressin, 1‐deamino‐8‐D‐arginine vasopressin (DDAVP), effectively decreased urine volumes and increased urine osmolality in all the patients. The peptide was used for long‐term treatment in seven cases. The results are discussed in relation to the pathogenesis of

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08089.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.In six normal persons reduced physical activity during the day did not influence the rise in blood ketone bodies during the evening, which was previously found in normal persons with normal physical activity. This rise, therefore, does not seem to be due to post‐exercise ketosis. During the evening free fatty acids (FFA) and glycerol in serum varied in principle in the same way as did the blood ketone bodies. The rise in blood ketone bodies can therefore be assumed to be due to an increased rate of formation of ketone bodies as a consequence of increased mobilization of FFA from adipose tissue. There was no evidence of a rise in serum growth hormone as trigger mechanism for the rise in blood ketone bodies. The rise in ketone body concentration was completely prevented by constant glucose infusio

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08090.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The Dextrostix Reflectance Meter (DRM) system has been used for monitoring of the blood glucose level during diagnostic hypoglycemia in 16 patients with suspected pituitary insufficiency. In the range 15–40 mg glucose/100 ml blood the reproducibility of the DRM system, + 1.7 mg/100 ml, was as good as that of the reference method. The agreement between values obtained with the DRM and the reference method showed a straight line relationship, the equation for the regression line beingy= 1.02x‐ 3.1 and the coefficient of correlation 0.94. The access to immediate and continuous information about the blood glucose level was of value for avoidance of complications and methodological misinterpretations, and permitted the test to be performed in open c

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08091.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.While the hypocalciuric action of thiazides is well established, their action on the intestinal absorption of calcium has remained a matter of dispute. In the present investigation this action has been studied in man by the measurement of forearm radioactivity in an Armac large volume liquid scintillation counter following separate oral and i.v. administration of47Ca. Determined in this way duplicate measurements of calcium absorption in the same individual yield a standard deviation of 3.2%. Oral administration of bendroflumethiazide, 10 mg/day, led to a significant increase in fractional calcium absorption in a group comprising patients with hypercalcaemic hyperparathyroidism (n= 7), normocalcaemic renal stone disease (n= 8) and postsurgical hypoparathyroidism (n= 1). The mode of action of thiazides on the intestinal calcium absorption is discussed. Probably thiazides promote in a specific way the transport of calcium through the intestinal as well as through the tubular epithelial cells.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08092.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The effect of L‐dopa on connective tissue biosynthesis by 10‐day‐old chicken embryos has been studied. Inhibited collagen formation as expressed by a reduced hydroxylation of (14C)proline and (14C)lysine, and a similarly reduced glycosylation of (14C)hydroxylysine was found. No influence on the biosynthesis of glyco‐and/or mucoproteins was o

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb08093.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY