ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03228.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Ischemic heart disease is more common in East Finland than in West Finland, but systematic comparison and follow‐up of incidence figures have not been possible. In 1972 the personal identification number became included in the hospital discharge records, which made it possible to link death certificate data with hospital records from the whole country. The results of this study suggest that high mortality from IHD in some regions is more closely associated with high incidence than a high fatality rate. The proportion of deaths outside hospitals showed large variation by province but this had rather little effect on the total one‐year survival ra

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03229.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.One hundred consecutive patients with angina pectoris referred for coronary arteriography were studied prospectively for non‐invasive assessment of left main (LMCA) or proximal left anterior descending coronary artery (proximal LAD) disease. Evaluation of echocardiography interventricular septal motion, history and exercise test response could not identify the patients with these specific lesions. It is concluded that LMCA and proximal LAD disease still remain largely unpredictable by non‐invasive me

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03230.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Thirty‐three patients with recurrent drug‐refractory ventricular tachycardia were treated with oral amiodarone during an average period of 6.1 months. In‐hospital monitoring for two weeks or more, electrophysiological tests and ambulatory ECG were used to evaluate the results. Twenty patients are still using the drug with complete control of the arrhythmia. Eleven have failed the drug, ten due to recurrence of documented ventricular tachycardia. Only three patients failed after the first month of therapy. Two patients died, one suddenly. The drug was dicontinued in a further two patients due to side‐effects. Other side‐effects were tolerable or manageable by dose adjustments alone. Five patients showed evidence of inadequate arrhythmia control between days 15 and 32 of therapy but subsequently responded to the drug for 4–9 months, giving further support to the concept that in some patients at least 30 days of therapy is necessary for the full effect of the drug to appear. In 16 of the 20 patients tested by arrhythmia induction study while on the drug, ventricular tachycardia could still be induced. Seven (44%) of these eventually failed the drug. Arrhythmia recurred in one of those four in whom tachycardia could not be induced. Amiodarone is a valuable drug in the management of recurrent ventricular tachycardia, refractory to other antiarrhy

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03231.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Antibodies against herpes simplex virus (HSV) and cytomegalovirus (CMV) were examined in sera from 132 patients with essential hypertension and 54 normotensive healthy subjects of the same age and sex. Prevalences of HSV and CMV antibodies (titre ≥4) were equal in patients and controls. A HSV antibody tire ≥4 was found in 39.5% (17/53) of patients with WHO stage III hypertension, in 26.2% (22/85) of patients with stage I–II hypertension, and in only 9.4% (5/54) of normotensive subjects (p<0.0005). The HSV antibodies were mainly of type 1. No association between CMV antibodies and vascular complications could be demonst

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03232.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.A prospective, randomized trial of two antibiotic combinations (amikacin plus either ampicillin or cephalotin) was performed on 39 consecutive episodes of fever in 30 patients with neutropenia and hematological malignancy. Infections were documented as the cause of fever in 37 episodes (95%): in 21 episodes (54%) bacteria or a virus (n=1) were isolated, and in 16 (41% of all episodes) the infection was documented clinically but no pathogen was isolated. The most frequently isolated bacteria were Staph, aureus (38% of all strains), E. coli (13%), and Pseudomonas aeruginosa (13%). Bacteremia occurred in 18% of the febrile episodes. Improvement followed treatment with the combination amikacin plus ampicllin in 73% of 19 cases, and with amikacin plus cephalotin in 55% of 20 cases (p>0.05), giving a total Improvement rate of 64%. Failure of therapy was seen in episodes caused by multiple bacteria or Pseudomonas infections. Mild signs of nephrotoxicity were noted in 13% during both regimens. Audiograms were normal in all but two patients who showed slight high‐frequency hearing loss. A second infection occurred in 7 episodes (18%). Thus, the combination of amikacin plus ampidllin was as efficient (but less expensive) as amikacin plus cephalotin in the initial treatment of febrile episodes in neutropenic patients with hematological malignancie

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03233.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Fifteen patients with multiple myeloma stage III were treated with a combination of cytostatics and plasmapheresis in a sequential trial running for 60 weeks. Thirteen patients showed clinical improvement and ten a reduction of their myeloma protein by at least 50%. Bone X‐ray examination was performed every 15 weeks. Progression of bone lesions was seen in one patient, whereas the radiographic picture was unchanged in the others. It is concluded that bone X‐ray, although essential in the diagnosis and staging of multiple myeloma, is not suitable for the monitoring of patients during treatm

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03234.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Total kidney volume, i.e. the combined volume of both kidneys (TKV), was determined by computerized tomography (CT scanning) during replacement therapy of terminal renal failure in 12 patients with adult polycystic kidney disease. Mean TKV was 2090 (872–3437) cm3in six of 11 patients with both kidneys in situ, treated for 44 (28–59) months, and 1184 (308–2761) cm3in five, treated for 97 (75–130) months. The difference is not statistically significant (0.1>p>0.05). Two patients, treated for 89 and 130 months, had a TKV of 308 and 408 cm3, respectively, i.e. almost equal to the normal (303 cm3(SD 29)). Six patients, five with both kidneys in situ and one unilaterally nephrectomized, were examined with two CT scans at an interval of 31 (17–46) months and all showed a significant decrease in TKV, averaging 0.77 (0.49–1.09)% per month of treatment. It is concluded that polycystic kidneys undergo involution during replacement therapy, but the gradual shrinkage may be difficult to verify by single volumetric measurements in patients treated for varying periods due to the large interindividual variation in TKV in adult polycystic kid

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03235.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Sympatho‐adrenally regulated mechanisms of the circulatory system have been studied in seven patients with hyperprolactinemia in order to evaluate the effects of long‐term (1–3 months) treatment with bromocriptine. Before treatment catecholamine excretion was within the normal range. Blood volume was low and there was a marked heart rate reaction to orthostasis. ECG showed no abnormalities. Blood pressure and ECG reaction during exercise were normal. The blood pressure heart rate response to handgrip was less marked than in healthy young men. During bromocriptine treatment, serum prolactin levels normalized in all but one patient. Total catecholamine excretion was lowered. Body weight diminished. Resting heart rate and blood pressure fell significantly. Blood volume per kg body weight remained unchanged as did the orthostatic heart rate increase. The circulatory response to handgrip was less marked than before therapy. It seems that long‐term bromocriptine therapy provokes a cardiovascular pattern reflecting an inhibition of sympatho‐adrenal

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03236.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The effect of microsurgery on growth hormone (GH) secretion was studied in 34 patients with acromegaly. All patients showed enlarged sella volumes according to encephalography and macro‐adenomas at surgery. Preoperative GH levels were elevated in all 34 patients and 14 had concomitant hyperprolactinemia. There was a correlation between basal GH levels and sella size. Visual field defects, suprasellar extension, long duration of the disease, hyperprolactinemia and aneuploidy were noted in patients with low as well as high levels of GH pre‐operatively. The average reduction of GH levels in the total series was 71 ± 21% (mean ± SD). A notably similar reduction of GH levels was seen regardless of preoperative GH levels, concomitant hyperprolactinemia, visual field defects, size of the adenoma, invasive growth or increasing experience of the surgeon. Therefore, normal GH levels after surgery were reached mainly in patients with moderate GH increments preoperatively. GH levels were normalized by surgery in 15 patients but only four of these showed normal GH response to TRH andl‐dopa tests. Thus, only four patients (12%) fulfilled these criteria for cure of GH home

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb03237.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY