ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08388.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.The flow obstruction in mitral valve implants was studied in the immediate postoperative period in 19 patients with Björk‐Shiley, Hancock, or Lillehei‐Kaster prosthetic mitral valves. The effective valve area (Ae) was used as a measure of the flow obstruction. The blood velocity in the implants was estimated with a non‐invasive ultrasound Doppler system. The cardiac output was determined with an indwelling thermodilution catheter. The collected data allowed the determination of Ae. Multiple determinations of Ae, at various cardiac outputs and pulse rates were generally performed in each patient during the first 2–3 postoperative days. The investigation demonstrated that the method employed was useful for the study of mitral implant performance. The obtained values of Aedemonstrated that the flow obstruction in prosthetic mitral valve implants is fiequently cons

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08389.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.A total of 140 patients given permanent pacemaker 1963‐73 were followed during three years with regard to survival. Indication for pacemaker implantation was AV block in 82% and disturbed consciousness in 84%. The first half of the series had a survival equal to that of the second half. The survival was 86, 73 and 64% and the excess mortality, which is above normal, was 9, 16 and 20% after one, two and three years, respectively. Concepts of fractional life‐time and death‐time were developed. These express the proportion of the total observation time that is life and death, respectively. The fractional life‐time was 0.80 and the fractional death‐time 0.20. The excess death‐time was 0.12 (12%) of the total observation time. Mortality, survival, life‐time and death‐time were compared in three studies, the present one and two from Denmark. The great similarities were obvious. An estimation of the un‐paced survival during three years, based on studies of AV block before the pacemaker era, indicated the great benefit of pa

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08390.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.Out of a total of 947 patients admitted to the CCU at Serafimerlasarettet during 2 years, all those with AMI and ventricular fibrillation (VF) or ventricular tachycardia (VT) during the CCU stay were selected. The QT interval could be measured in 15 patients with VF and 12 with VT before the event. The QT interval was also measured in two control groups; one consisted of 27 consecutively admitted patients with AMI without ventricular arrhythmias (VA), the other of 27 non‐AMI patients treated in the CCU. Most patients in the group with VA showed pathologically prolonged QT intervals and there were statistically significant differences between this group and the control groups regarding corrected mean QT intervals. If these findings are confirmed, QT measurements might be of value in the prediction of malignant VA in AM

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08391.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.The metabolism of α‐methyldopa was studied in 5 patients with febrile reactions to the drug, and compared with the metabolism in 5 patients without such reactions and in 4 normal subjects. A depression of the drug metabolism was found in drug fever patients, which may affect either the intestinal mucosal conjugation of the drug or the hepatic transformation. The decreased metabolism is assumed to be a possible causative mechanism of the adverse drug reacti

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08392.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.Three patients are described in whom malignant ventricular arrhythmias appeared in connection with a reinfarction some days after hospitalization for an acute myocardial infarction and in whom massive doses of procainamide, up to 7.5 g/day i.v., were necessary to prevent these arrhythmias. The serum concentration of procainamide was 2–4 times higher than the recommended upper level, but no side‐effects were observed. With the dose given, one would have expected still higher serum concentrations. Several reasons for this finding are discussed, including the effects of renal function, intestinal leakage, storage of the drug in tissues and hitherto unknown metabolic pathways of procainamide in patients, who are slow acetylat

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08393.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.The effect of propranolol (40 mg t.d.s.) on the peripheral levels of T4, T3and reverse‐T3was studied in 26 patients with hyperthyroidism. The compounds were measured by specific radioimmunoassay techniques. The levels were followed for five weeks and compared with the levels before treatment. The results show that propranolol had no significant effect on the peripheral levels of T4despite a rapid amelioration of clinical symptoms. A significant reduction of T3levels was obtained during the first to fourth week of treatment. No significant decrease was obtained after the fourth week. A significant elevation in reverse‐T3levels was obtained during the second to fourth week of treatment. No significant change was obtained either during the first week or after the fourth week. Inconsistent fluctuations in hormone levels, both before and during treatment, could be seen in individual cases. The results suggest that the reduction of clinical symptoms must be caused by an extrathyroidal action of propranolol which does not seem to involve the pituitary gl

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08394.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.Systolic time intervals (STI) have been used in evaluating cardiac function in 21 patients who had taken an overdose of drugs. Registrations were made in all patients on arrival at the hospital and on the third day. On arrival STI was abnormal in 16 patients (76%). At the second registration it was still abnormal in ten (48%). Prolongations of total electromechanical systole (QS2) and preejection period (PEP) were the most frequent findings. The patients with abnormal STI at the first registration showed a significant improvement in QS2 (p<0.01) and PEP (p<0.05) from the first to the third day. Two of the four patients who had taken amitriptyline in a slow release form showed a prolongation of PEP and an increase in PEP/LVET from the first to the third day, and one patient had a further prolongation on the fifth day. The findings may be explained by a reduction of cardiac contractility caused by the membrane‐stabilizing effect of the drug

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08395.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.In view of the presumed increased susceptibility of chronic alcoholics to infectious diseases, the influence of alcohol in vitro on leucocyte adherence, neutrophil chemotaxis, phagocytosis and intracellular killing was investigated with highly standardized methods. A significant inhibitory influence on these leucocyte functions was found only at alcohol concentrations in excess of those obtained clinically. An interesting observation not reported before was increased adherence, phagocytosis and chemotaxis at low to moderate concentrations of alcohol.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08396.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

ABSTRACT.The serum and CSF proteins were analyzed by isoelectric focusing in 16 male alcoholics after alcohol intoxication and after 10–14 days of alcohol abstinence. An abnormally marked protein band with pI 5.7 was found in serum in 15 patients and in CSF in 12 at the first examination. On crossed immunoelectrofocusing it appeared as an increased, cathodal, microheterogeneous molecular form of transferrin. The abnormality was reversible and decreased or normalized in serum in all cases after abstinence. In 6 patients with clinical signs of cerebellar degeneration, an abnormal microheterogeneous pattern of CSF transferrin of partly different appearance to that in serum remained after abstinence. Disturbed liver synthesis of transferrin is a probable origin of the serum finding, which may be specifically related to alcohol abuse. Substitution or loss of acidic amino acids and/or decreased iron binding ability are possible structural explanation

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1978.tb08397.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY