ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08562.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The ability of routine analyses of cerebrospinal fluid (CSF) to differentiate between haemorrhage and infarction was evaluated in 231 stroke patients, whose diagnoses were based on computed tomography or autopsy. In all diagnostic groups the mean protein level was above normal, the highest values being associated with haemorrhage. Taking a protein level>1 g/l to be characteristic of bleeding, sensitivity was 89% and specificity 92%. Spectrophotometric CSF absorbance was measured at wave lengths of 410, 415, 455 and 630 nm. Validity was equal for the first three. Taking absorbance ≥0.040 at 415 nm to be diagnostic for haemorrhage, sensitivity was 72% and specificity 94%. The human eye was almost as sensitive as spectrophotometry in this context. Thus, among 100 patients with stroke, 7–9 out of 10 plausible cases of haemorrhage would be identified by means of routine CSF analyses. At the same time, 5–9 patients with ischaemic lesions would be diagnosed incorrectly as ble

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08563.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.Thermography, clinical examination and99Tcm‐plasmin test were performed in 112 patients and compared with phlebography. The study population consists of consecutive outpatients with symptoms compatible with deep venous thrombosis, who presented during regular clinic hours. Scoring systems were constructed for the clinical and thermographic evaluation. Both thermography and clinical diagnosis were insufficiently sensitive and specific for screening purposes. Plasmin test had a high sensitivity, 95%, but a low specificity. It is possible that a combination of thermography and clinical diagnostic criteria can provide an acceptable screening procedure. Combining thermography wiht a routine examination by the physician on duty yielded less favourable result

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08564.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The antiarrhythmic effects of tocainide, administered as a bolus injection of 750 mg followed by oral therapy, and conventional Iidocaine therapy were evaluated in 40 patients admitted for suspected acute myocardial infarction (AMI) and showing high‐grade premature ventricular complexes (PVCs). The mean hourly PVC rate before therapy was 928 and its reduction was equally significant in the tocainide group, 73%, and in the Iidocaine group, 68%. The number of 5‐minute periods with multiform, paired and R/T PVCs or ventricular tachycardia was also significantly reduced, by 78% in the tocainide group and by 71 % in the Iidocaine group. Ten patients in the tocainide group reported moderate side‐effects, compared to 13 in the Iidocaine group, where the infusion had to be discontinued in 5 patients and the rate had to be reduced in 4. Tocainide, an amine analogue of Iidocaine, is considered just as effective as Iidocaine in patients with high‐grade PVCs and suspec

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08565.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.Evidence for the association between Coxsackie B virus infections and myocardial infarction was studied in a prospective follow‐up examination. Using the micro neutralization test, 9 (15%) of 59 patients with acute myocardial infarction and 1 (2.6%) of 38 control patients showed a fourfold, or higher, antibody increase in paired serum samples against Coxsackie B1‐5 viruses. This difference is significant (p≤0.05). None of the patients or controls revealed symptoms of a viral infection during the blood sampling. Virus isolation from throat and feces was negative in all patients and controls. This finding agrees with some previous studies suggesting that the Coxsackie B group may in some cases have a causal role in myocardial infarction, or may act as a triggering f

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08566.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.In a ten‐year prospective study of a population of men and women aged exactly 70 at entry and otherwise selected only according to geography, the predictive values of serum cholesterol and serum triglycerides were evaluated concerning total mortality and cardiovascular disease (CVD) and cancer manifestations in the eighth decade. Both high and low cholesterol values at 70 were associated with excess total mortality in men, the former showing excess CVD mortality, the latter excess cancer mortality. In men, high values of triglycerides at 70 were associated with increased CVD mortality as well as CVD development. In women, high values of triglycerides at 70 were associated with excess hospitalization for cerebrovascular incidence alon

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08567.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The mechanism of ischaemic ST depression and the cause of its low sensitivity to coronary artery stenosis are not well understood. Of 30 patients with severe stable effort angina, 19 (63%) showed ischaemic ST depressions after exercise (the STAE group) and 11 did not. The highest load during the symptom‐limited exercise test and the heart rate on that load did not differ between the two groups. The clinical characteristics and angiographic findings were also similar, bat the findings at heart catheterization differed during exercise (in supine). Although the load was similar, the stroke index was significantly lower (38 vs. 53 ml/m2BSA) and the left ventricular end‐diastolic pressure rose to a significantly higher value in the STAE group (40 vs. 32 mmHg). When STAE occurred, they were exclusively or concomitantly present in chest lead 5. These findings suggest that ischaemic STAE may not reflect regional ischaemia but the consequent left ventricular dysfunction. The mechanism may, for example, be that a sufficiently elevated left ventricular diastolic pressure causes a global subendocardial ischae

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08568.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.A community‐based programme to influence the risk factors of coronary heart disease was carried out in North Karelia, Eastern Finland in 1972‐77. The evaluation, based on examination of large cross‐sectional random samples at the outset and at the end of the period, showed a greater reduction in both serum cholesterol and blood pressure levels in North Karelia than in a matched reference area. A random cohort of 293 men and 321 women who were studied both in 1972 and in 1977 did not use antihypertensive drugs on either occasion. Among these people the change in blood pressure was positively associated with the change in serum cholesterol even when age, initial blood pressure, changes in body mass and number of blood pressure measurements were allowed for. This finding supports the hypothesis that changes in fat consumption lead to changes in blood pressure, but this hypothesis needs further investig

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08569.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.1,25‐Dihydroxycholecalciferol (1,25‐DHCC) was administered to four patients on maintenance hemodialysis and to four patients with renal failure not requiring hemodialysis. Secondary hyperparathyroidism was found in both groups of patients. Before initiation of 1,25‐DHCC treatment both groups had serum 1,25‐DHCC levels below the normal range (33.1 +15.3 pg/ml). During the treatment period, serum 1,25‐DHCC concentrations were normalized. Parathormone concentration in serum decreased in both groups during the observation period. Serum calcium concentration was normalized in patients with renal failure and within the upper normal range in patients on maintenance hemodialysis. Bone biopsy and densitometry of the radius showed a trend towards normalization of bone during the treatment period, while X‐ray studies showed no clear effect of 1,25‐DHCC treatment. This study shows that changes in bone mineralizatoin can be reversed by normalization

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08570.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.Antinuclear antibodies were significantly more prevalent (p<0.01) in 143 patients with alcoholic cirrhosis than in 64 patients with alcoholic steatosis and in 94 controls. Smooth muscle antibodies were significantly more prevalent (p<0.05) in patients with alcoholic steatosis and cirrhosis than in controls. The prevalence of antimitochondrial antibodies and IgG liver membrane antibodies did not differ significantly between the three groups. Immunoglobulin G, A, and M concentrations were only occasionally increased in patients with steatosis. Patients with cirrhosis had significantly increased (p<0.005) concentrations of immunoglobulins G, A, and M when compared to patients with steatosis. These results indicate that the degree of liver damage has more effect than chronic alcoholism on the humoral immune system. Whether this influence is direct or indirect remains to be established.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08571.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY