ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02897.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Megaloblastic anemia and small intestinal diverticulosis in a 79‐year‐old woman are reported. Laboratory studies showed normal secretion of intrinsic factor and that the anemia was due to defective absorption of vitamin B12. The bacterial concentration in duodenal fluid was 3,400,000 E. coli per ml. In vitro the bacteria had a high uptake of “free”57CoB12and a low uptake of57Co bound to intrinsic factor. This supports the theory that small intestine bacteria cause vitamin B12malabsorption by inhibitory action on the absorptive epi

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02898.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.The case history of a 26‐year‐old woman with Wegener's granulomatosis is presented. There were clinical signs of cutaneous, pulmonary, mastoidal and renal involvements. During an oliguric period of five weeks life was maintained by peritoneal dialysis. Eventually she responded favourably to combined treatment with azathioprine and corticosteroids. During one year's follow‐up the serum creatinine level has remained unchanged at about 2 mg/100 ml. There has also been a marked improvement of the other manifestations of the disease, and her general condition is

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02899.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Lipolysis measured as glycerol release from rat adipose tissue in vitro was inhibited by chlorpropamide. This antilipolytic effect was independent of the addition of glucose to the incubation medium. At the same time chlorpropamide decreased the re‐esterification of FFA formed by lipolysis. This inhibitory effect was more pronounced in tissue incubated in medium with glucose present. Since lipolysis as well as re‐esterification of FFA is accelerated by glucose, present data would indicate that chlorpropamide primarily interferes with the glucose metabolism or the stimulatory action of glucose on the two pathways of the triglyceride‐FFA cycle. Chlorpropamide (1 mg/ml) had no effect on the glycerol release and lipogenesis of human omental tissue. The present findings lend no support to the recent theory that sulfonylureas decrease the plasma levels of FFA and glycerol in man by direct action of the drug on adipose t

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02900.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.A standardized work test has been performed by healthy subjects, patients with coronary heart disease, patients with arterial hypertension, and with the vasoregulatory asthenia syndrome. Heart frequency and rating of perceived exertion according to a rating method were assessed at various work loads. Different measures of physical working capacity were estimated.Patients with vasoregulatory asthenia—and patients with arterial hypertension, although less markedly—rated the exertion to be less in relation to heart frequency than healthy controls, particularly at low rating levels. On the contrary, patients with coronary heart disease rated the exertion to be higher, particularly at high ratings, in relation to heart frequency.In all patient groups studied, there was a smaller mean increase in heart rate in relation to a given increase in rating of exertion, i.e. for a given increase in heart rate there was a greater increase in rating of exertion than in healthy controls.Submaximal measures of physical working capacity were based on heart rate and rating of perceived exertion. The ratio between measurements of physical working capacity based on heart rate and those based on rating of perceived exertion was low in the VA group and high in patients with coronary insufficiency when compared with controls of equal age. Patients with a low “maximal” performance during the test also had a low submaximal physical working capacity estimated from heart frequency as well as from rating of perceived exertion.The difference found between the various patient groups, especially that between patients with coronary heart disease and patients with the vasoregulatory asthenia syndrome is of differential diagnosti

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02901.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Renal biopsies of 63 patients with acute oliguric renal failure have been studied. Interstitial cellular infiltration and oedema occurred in 76% of the patients. Follow‐up biopsies on 18 patients showed that chronic interstitial changes are frequent at least when the acute renal failure is due to a nephrotoxic agen

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02902.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.The combined diuretic action of quinethazone and furosemide has been studied in 24 patients with congestive heart failure maintained on a constant diet. The study was performed as a permutation trial test in which the error variance is reduced while permitting the examination of drug effects separate from the variations due to different patients and varying sequence of administration of drugs. The diuretic response to single drugs and to the combination of drugs in half doses showed exactly the same trend in 12 patients with slight to moderate degree of sodium retention as in 12 patients with severe sodium retention given double doses of diuretics. The results obtained indicate an additive effect of the combination of diuretics in terms of osmolal clearance, urinary sodium and chloride output as well as in terms of the development of hypochloraemic, hypokalemic alkalosis. The diuretic action of furosemide differed significantly from that of quinethazone. The renal tubular response to furosemide was characterized by: (a) a larger increase in natriuresis with rising doses; (b) a significant decrease of tubular reabsorption of solute free water; and (c) a shorter duration of action. Apparently the combined effect of the two drugs is most easily explained when it is assumed that the two diuretics, at least in part, inhibit renal tubular sodium reabsorption at different sites in the nephron. The combination of quinethazone and furosemide may prove useful in the treatment of refractory cardiac oedema when precautions are taken to avoid serious electrolyte disturbances.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02903.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.In 11 normal persons and 16 uraemic patients serum calcium, serum phosphorus, and calcium pool (exchangeable calcium) were determined (Heaney and Whedon (9)). Among the 16 uraemic patients eight had inulin clearance40 ml/min. Nine of the uraemic patients had serum calcium levels below normal (inulin clearance<40 ml/min) and six serum phosphorus above the normal range (inulin clearance20 ml/min. In four of the uraemic patients with inulin clearance<20 ml/min exchangeable calcium decreased. In patients who showed an increase the exchangeable calcium again declined towards the initial values at the end of some months.The bone formation rate was determined in 12 of the uraemic patients (mean = 14.5 ± 8.6 mg/kg, in normals 12.2 ± 2.3 mg/kg; this difference is not significant). Here, too, the highest values were found in patients with severe bone complications. In 11 of these patients the effect of aluminium hydroxide was studied (seven with inulin clearance<20 ml/min, three with inulin clearance between 20 and 40 ml/min, and one with inulin clearance above 40 ml/min). The values rose in all patients with inulin clearance above 20 ml/min and in five with inulin clearance below 20 ml/min. After some time, the bone formation rate declined towards the initial values.There was a correlation between exchangeable calcium and bone formation rate (r= 0.740) and between the fall in serum phosphorus and the increase in bone formation rate (r

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02904.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.A comparison of the abdominal subcutaneous fat tissue blood flow (FBF) has been made in 13 patients with diabetes mellitus and in 29 healthy individuals. As the metabolic state may influence the tissue blood flow, as well as vice versa, a possible relationship between FBF and the arterial levels of glucose, lactate, pyruvate,β‐hydroxybutyrate, free fatty acids and aceto‐acetate was searched for.The blood flow was calculated from the elimination curves from locally injected radioactive xenon.The average blood flow was significantly (p<0.001) higher in the diabetics than in the healthy individuals. There was a significant correlation between FBF and the abdominal skin temperature both in diabetics and in healthy individuals. The skin temperature was significantly higher in the diabetics.The administration of insulin to the diabetics lowered the FBF. Prolonged fasting increased FBF in the healthy controls, as judged from observations after 17 hours of fasting. Fasting for 34 hours did not further change the FBF. No correlation was observed between the FBF and the arterial concentration of any of the substrates anal

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02905.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Proteins in serum and concentrated urine from 41 patients suffering from renal diseases have been examined by electrophoresis in cellulose‐acetate gel, immunoelectrophoresis, and estimation of the immunoglobulin content. Clearance of electrophoretic fractions and immunoglobulins was assessed and each value was expressed as a proportion of the albumin clearance.Patients with pyelonephritis and polycystic kidneys excreted relatively more globulin than did patients with glomerulonephritis, diabetic nephropathy, SLE, and renal amyloid. The difference was most marked in the case ofβ‐globulin, and immunoelectrophoretic analysis showed that this fraction in the first‐named patient group consisted almost exclusively of transferrin.Immunoglobulin excretion showed no marked difference between the patient groups, with the exception that the urine of the pyelonephritis and the polycystic‐kidney patients always had a low content of IgA. Other variations could be attributed to variations in the total protein clearance.The presence of bacteriuria did not influence the composition of the urine protein. High clearance of protein was noted only in patients with relatively well preserved renal function. In pyelonephritis the proteinuria was similar at different degrees of renal failure.The results are discussed with respect to the origin of proteinuria associated with renal tubular

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1970.tb02906.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY