ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09919.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09920.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09921.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.The lecithin: cholesterol acyltransferase (LCAT) activity of lipoprotein depleted normal and fish eye disease (FED) plasma was assayed in a modified Glomset‐Wright incubation system where the enzyme was allowed to act on three different normal lipoprotein substrates consisting of an authentic mixture of very low (VLDL), low (LDL) and high (HDL) density lipoproteins to assay total LCAT activity, HDL to assay α‐LCAT activity and combined VLDL and LDL to assay β‐LCAT activity, respectively. However, using normal plasma depleted of HDL, leaving its combined VLDL and LDL as enzyme substrate, resulted in a more than twofold increase in the LCAT activity of FED plasma from the two patients compared to the activity obtained with HDL present in the incubation mixture, indicating an inhibitory effect of HDL on the β‐EAT activity present in FED plasma. This inhibitory effect of normal HDL could also be demonstrated by autoincubation of FED plasma mixed with isolated HDL2or HDL3Both these HDL subfractions had a pronounced inhibitory effect on the cholesteryl ester formation in FED plasma. The present study thus clearly demonstrates that normal HDL inhibits the β‐LCAT activity present in FED plasma, esterifying the free cholesterol of combined VLDL and LDL, derived from controls as well as from the two

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09922.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.The phospholipase A2and acyltransferase activities characteristic of human plasma lecithin: cholesterol acyltransferase have been evaluated in incubation mixtures of lipoprotein depleted plasma of fish eye disease patients and autologous HDL or homologous normal HDL3. Both enzyme activities were strongly reduced as compared to those of normal controls. These findings further support the claim that fish eye disease plasma has a specific lack of high density lipoprotein lecithin: cholesterol acyltransferase (α‐LCAT deficiency), although the cholesterol esterification of combined VLDL and LDL in such plasma proceeds at a normal ra

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09923.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Prodromal symptoms within four weeks prior to an acute event leading to coronary care unit admission have been studied in 276 consecutive patients interviewed within 24 hours after arrival at hospital. Coronary heart disease (CHD) was diagnosed in 237 patients, 140 of whom did develop acute myocardial infarction (AMI) (Group I) and 97 who did not (Group 2). Of the remainder, 15 had miscellaneous heart diseases (Group 3) and 24 no heart disease (Group 4). Unstable angina pectoris was equally frequent among CHD patients with and without development of AMI and was related to a higher hospital mortality in AMI patients. Less specific symptoms occurred with equal frequency in the four groups. Patients who developed AMI were not possible to identify by prodromal symptoms.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09924.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.One hundred and eleven carotid vessels in 56 patients were analysed by high‐resolution duplex ultrasound. Vessels were graded as normal, 25,50 or 75% stenotic and 100% occluded and the results were compared with similarly graded biplanar angiograms. There was absolute agreement in 68.5% of the vessels, agreement within one grade of severity of disease in 27.0%, while poor correlation was obtained in 4.5%. The results of ultrasound and angiography were also related to the surgical specimens obtained after thrombendarterectomy of 23 vessels in 20 patients. Good agreement was obtained between the three methods in 20/23 vessels. In one case ultrasound was better than angiography, in another case the reverse was true and in a third case both methods overdiagnosed a plaque. It is concluded that duplex ultrasound will work in the hands of a clinician and is a reliable non‐invasive screening method for carotid artery disease leading to a more optimal selection of candidates for angiogra

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09925.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Of 388 patients consecutively referred to echocardiography, 49 were suspected of having a cardiac source of systemic arterial embolism (SE). Mitral annulus calcification (MAC) was revealed in 27% of the patients with SE and in 8% of the remaining patients (p<0.05). The group of patients with SE were slightly older (median age 67 years) and included more female patients (47%) compared to the group without SE (62 years,p0.05). However, the small differences in age and sex distribution did not explain satisfactorily the considerably increased prevalence of MAC in the group of patients with SE. Our preliminary data indicated that thromboembolism caused by left atrial dilatation and atrial fibrillation might be the most important cause of the condition in patients with MAC and SE. However, the significance of the possible mechanisms of embolism in patients with MAC and the incidence of the complication should be further clarified before therapy and prophylaxis can be suggested.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09926.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Forty moderately overweight men with high waist/hip girth ratio and mild hypertension participated in a trial with gel‐forming fiber—guar gum. After two weeks of familiarization and controlled food intake, ensuring weight stability, the participants received 7 g of guar three times daily during two weeks. Patients were then followed during a 5‐week wash‐out period. There were no changes in body weight and body composition but total cholesterol decreased during gum treatment. Blood pressure measured at standing, supine and sitting positions decreased after two weeks of guar treatment by 9.8% systolic and 9% diastolic and did not revert to pre‐treatment values until after three weeks of the wash‐out period. There was also a decrease in both systolic (8 %) and diastolic (7%) blood pressures during exercise on the ergometer bicycle at 50 and 100 W (4.6 and 4.7% respectively) submaximal work load. It is concluded that mar gum exerts a lowering effect on the blood pressure in moderately obese men even in the absence of any change in body weight. If confirmed in further long‐term studies, guar may be a valuable alternative to pharmacological preparations in the treatment of mild

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09927.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Epidemiological and prospective studies in man and animals have indicated an inverse relationship between calcium intake and cardiovascular mortality and blood pressure (BP). We have therefore studied the effect of dietary calcium on blood pressure in two groups of women. In a cross‐sectional study 103 early postmenopausal women were stratified into three groups according to daily calcium intake calculated from a questionnaire. Both diastolic and systolic blood pressures were identical in the three groups. We thereafter conducted a prospective placebo‐controlled trial on the effect of calcium supplementation. Twenty‐eight healthy women were randomized to placebo treatment (n=14) or calcium supplementation 2000 mg daily (n=14) for one year. In both groups BP remained at initial levels throughout the study and was identical in the two groups at measurements every three months. We thus conclude that calcium supplementation has no effect on BP in normotensive subjects on a high calcium

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb09928.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY