ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10631.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10632.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10633.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTTwenty‐two patients with the Swedish variant of familial amyloidosis with polyneuropathy were studied by M‐mode and two‐dimensional echocardiography. These patients had few symptoms consistent with cardiac disease but, nevertheless, echocardiograms of only two of them, both with a short history of the disease, were considered normal in all aspects. The most common abnormality was increased thickness of the interventricular septum found in 20 (91 %) of the patients. This septal hypertrophy was asymmetric in 12 (55 %) of them. Two‐dimensional echocardiography revealed a characteristic hyperrefractile appearance of the myocardium in 15 (68%) of the patients. Thus, echocardiography showed a characteristic pattern in these patients. This study also indicates that cardiac amyloidosis can be diagnosed in the preclinical, asymptomatic state by M‐mode and two‐dimensional echoc

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10634.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTMusculo‐skeletal symptoms were screened in 24 consecutive patients with newly diagnosed sarcoidosis and followed up two years later. Ten patients had joint involvement. Symptoms were most frequently found in ankle joints, followed by hand and knee joints. Arthritis was found in seven (29%) patients, two of whom suffered from monoarthritis of foot and wrist joint, respectively. Three patients had tenosynovitis. Muscle symptoms such as myalgia were present in six patients. Open biopsy of the gastrocnemius muscle showed epithelioid cell granulomatosis in nine of 20 patients. Only three of these nine patients had symptoms of myalgia, although not in the biopsied muscle. At follow‐up, musculo‐skeletal symptoms were found in only three patients, all of whom initially had Löfgren's sy

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10635.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTIn a 10‐year longitudinal study of men and women aged exactly 70 at entry and otherwise only selected according to geography, the predictive value of arterial blood pressure was evaluated concerning cardiovascular disease (CVD) at entry and CVD development or death during the following decade. At 70 the prevalence of arterial hypertension (≤ 160/95 mmHg) was 46% in men and 45% in women. At 80 these prevalences were 19 and 30%, respectively. In women, this fall could partly be explained by an association between high blood pressure and excess mortality. In both sexes it could partly be explained by an increasing part of the population being treated with antihypertensives/diuretics, partly by an association with myocardial degnereration. In a Cox's regression model for competing risks at 70, high systolic blood pressure had independent, predictive value for excess CVD mortality in the eighth decade in women alone, and for excess CVD development in both sexes. High diastolic blood pressure had no independent predicitive value for any of these end poi

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10636.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTThe long‐term effect of ventricular inhibited (VVI) and atrial triggered ventricular (VAT) pacing on cardiac performance was determined by cardiac catheterization at rest and during exercise in 9 patients with high‐degree AV block. Cardiac output (Q) increased at rest by 22% during VAT vs. VVI (5.5 vs. 4.5 l/min,p<0.01). An increased stroke volume constituted the difference (75 vs. 63 ml,p<0.05). Mean working capacity increased by 12% in the supine position with VAT vs. VVI (p<0.05). During exercise Q increased by 40% with VAT vs. VVI (10.2 vs. 7.3 l/min,p<0.01) due to an increase in heart rate. Most pressures were largely unchanged. Stroke work and atrial rate decreased during VAT vs. VVI, which may indicate a lower sympathetic activity with VAT vs. VVI. The study demonstrated that hemodynamic advantages of VAT are still obtainable after several years of VVI pac

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10637.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTLeft ventricular (LV) volumes were assessed with equilibrium radionuclide angiocardiography at rest and during exercise in nine patients with high‐degree AV block treated with ventricular inhibited pacing (VVI), which was subsequently changed to atrial triggered ventricular pacing (VAT). The ventricular rates were similar at rest but higher on exercise during treatment with VAT (102 bpm) than with VVI (71 bpm). The LV end‐diastolic volume tended to be larger with VAT than with VVI pacing, both at rest (185 vs. 145 ml) and during exercise (220 vs. 162 ml). The LV end‐systolic volume also tended to be larger at rest (110 vs. 81 ml) and during exercise (149 vs. 83 ml). The LV ejection fractions were similar at rest but on exercise they decreased to significantly lower levels with VAT (0.35), while remaining unchanged with VVI (0.47). One mechanism for this difference could be an enhanced contractile state in VVI pacing compared with VAT p

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10638.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTIn 14 patients with symptomatic high‐degree AV block, studies were carried out of the effect on physical working capacity when an atrial triggered mode of cardiac pacing (VAT) was substituted for ventricular inhibited pacing (VVI). The tests were designed to elucidate the quantitative relationship between the effect of rate increase and AV synchronization by comparing VVI pacing matched to the same rate as VAT. The work load was increased by 10 W/min. The physical working capacity increased by 25 % with VAT as compared with VVI (p<0.001). The improvement was entirely attributed to heart rate increase, and not to AV synchronizatio

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10639.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTThe aim of this study was to explore the differences in normalization between different organ functions in hypothyroid patients during substitution. The study included 21 hypo‐thyroid patients who were substituted with gradually increasing doses of thyroxine (T4) and studied repeatedly for up to 20 or 32 weeks. The different peripheral organ functions were compared with regard to the dose and duration of substitution necessary for a 50 % therapeutic effect. The circulatory response to an orthostatic test, the decrease in low density lipoprotein cholesterol and thyroid stimulating hormone concentrations, the lipoly‐tic effect of physical exercise and the increase in triiodothyronine concentration showed a 50% response to substitution within 3.3–4.6 weeks of therapy and at a T4dose of 0.04‐0.06 mg/day. In contrast, the 50% therapeutic effect on the lipolytic response to an intravenous l‐noradrenaline infusion and the maximal working capacity on ergometer bicycle was not observed until 6.2–9.0 weeks of therapy and T4doses of 0.08‐0.11 mg/day. The differences observed in the peripheral responses might be of clinical importance when severely hypothyroid patients must be substi

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb10640.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY