ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03245.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03246.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03247.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Suhonen O, Reunanen A, Aromaa A, Knekt P, PyÖrÄlÄ K. (Research Institute for Social Security, Social Insurance Institution, Helsinki, Finland.) Four‐year incidence of myocardial infarction and sudden coronary death in twelve Finnish population cohorts.The incidence of myocardial infarction (MI) and sudden coronary death in four years was studied in 6510 men and 5800 women, aged 30–59 years, derived from 12 Finnish population cohorts constituting the invited population to a prospective study. The incidence of all fatal coronary events in four years was 13.0/1000 in men and 1.8/1000 in women. The incidence of sudden coronary death was 7.8/1000 in men and 0.7/1000 in women. The incidence of non‐fatal MI was 22.2/1000 in men and 7.3/1000 in women. Coronary mortality was significantly higher in non‐participants in the initial survey than in participants. The incidence of MI was highest in men from eastern Finland (North Karelia), intermediate in men from central and western Finland and lowest in men from southwestern Finland. There were no significant regional differences in the incidence of MI in women. The incidence of MI in this study was in good agreement with that recorded in the myocardial community

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03248.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Engby B, Strunge P, Olsen J. (Department of Internal Medicine, Horsens Hospital, Horsens, Denmark.) The prognosis for patients referred with suspected acute myocardial infarction.A follow‐up investigation of the prognosis of 381 patients admitted with suspected acute myocardial infarction (AMI) has been carried out in respect of later AMI or death. During hospitalization the patients were divided into groups with particular attention to patients with no demonstrable myocardial infarction but with ischaemic heart disease (non‐AMI) and patients with confirmed AMI. All patients were subjected to follow‐up for 43 months (range 37–54). The mortality from cardiovascular causes after four years was 26.2% of 130 non‐AMI patients and 25.8% of AMI patients. The majority of new infarctions were found in the AMI patients, but with even increase in both groups, 50% occurring within the first 12 months. The groups were studied with regard to earlier manifestations of ischaemic heart disease and heart failure during hospitalization, without any difference being observed. Due to the poor prognosis the question is raised whether non‐AMI patients as a group should be offered prophylac

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03249.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Luoma PV, Savolainen MJ, Sotaniemi EA, Arranto AJ, Pelkonen RO. (Clinical Research Unit, Department of Medicine, and Departments of Medical Biochemistry, Pathology and Pharmacology, University of Oulu, Oulu, Finland.) Plasma HDL cholesterol and blood glucose in non‐insulin‐dependent diabetics related to liver lipids and microsomal enzyme activity.The major lipid predictors of coronary events, plasma high density lipoprotein cholesterol (HDL‐C) and the HDL‐C/total cholesterol (T‐C) ratio, and blood glucose (BG) in 12 subjects with non‐insulin‐dependent diabetes mellitus were related to hepatic lipids, proteins and microsomal enzyme activity assessed by liver cytochrome P‐450 (P‐450). Non‐insulin‐dependent diabetics had low HDL‐C/T‐C ratio, liver phospholipid (PL) and P‐450 and high serum and liver triglyceride (TG) concentrations. Plasma HDL‐C was decreased, and BG high, especially in subjects with reduced PL and P‐450. The HDL‐C/T‐C ratio was directly proportional to liver PL and P‐450 and unrelated to hepatic TG. Increases in liver PL and microsomal enzyme activity may be favorably reflected both in choleste

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03250.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Lapidus L, Bengtsson C, Lindquist O, Sigurdsson JA, Rybo E. (Departments of Medicine II and Clinical Chemistry, Sahlgrenska Hospital, Gothenburg University, Gothenburg, Sweden, and Health Centre, HafnarfjÖrdur, Iceland.) Triglycerides—main lipid risk factor for cardiovascular disease in women?A 12‐year longitudinal population study of 1462 women, aged 38–60, was carried out in Gothenburg, Sweden in 1968‐69. Women with high initial serum triglyceride values had a higher 12‐year incidence of myocardial infarction, stroke and total mortality than the others. The findings for serum triglycerides persisted for myocardial infarction, stroke and total mortality after adjustment for other possible risk factors for ischaemic heart disease such as age, systolic blood pressure, smoking, indices of obesity and serum cholesterol, while serum cholesterol did not predict any end‐points studied when taking other risk factors including serum triglycerides

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03251.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Carlson LA, Holmquist L. (King Gustaf V Research Institute and Department of Internal Medicine, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden.) Paradoxical esterification of plasma cholesterol in fish eye disease.The activity of lecithin: cholesterol acyl transferase (LCAT), the enzyme which catalyses the esterification of human plasma cholesterol, has been measured by two independent methods in plasma from the two known living Swedish patients with fish eye disease. The enzyme activity was in both cases about 15% of that of normal plasma. Paradoxically, however, the percentage of plasma cholesterol which was esterified was almost normal in both patients. In addition, a normal spectrum of the fatty acids of the cholesteryl esters was present indicating a normal cholesterol esterification pathway in vivo. Incubation experiments in vitro of plasma from the two patients also yielded normal cholesterol esterification rates when measured by two different methods. These paradoxical results for cholesterol esterification are discussed on the basis of the present biochemical knowledge of fish eye disease and LCAT deficiency.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03252.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Hesse B, Rasmussen S, Lund JO, Christensen P, Damkjær Nielsen M. (Department of Clinical Physiology, Glostrup Hospital, and Institute for Experimental Medicine, Copenhagen, Denmark.) Urinary excretion of kallikrein before and after operation for aldosterone‐producing adenoma.Urinary kallikrein excretion (UKal), determined by the esterase method, was measured in 10 normotensive volunteers, 10 patients with essential hypertension and in 7 patients with primary aldosteronism before and after operative removal of the adenoma. UKal values were low in 5 of the patients with essential hypertension. Preoperative UKal values in the patients with aldosteronism did not differ significantly from those of the normal subjects, but decreased in all after operation in parallel with changes in urinary excretion of tetrahydroaldosterone and plasma aldosterone concentration. The study supports the assumption of an association between the renal kallikrein‐kinin system and the mineralo‐corticoid state

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03253.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

ABSTRACT.Ikkala E, MyllylÄ G, Pelkonen R, Rasi V, Viinikka L, Ylikorkala O. (Finnish Red Cross Blood Transfusion Service and Helsinki University Central Hospital, Helsinki, Finland.) Haemostatic parameters in Cushing's syndrome.We have studied haemostatic parameters in 12 patients with Cushing's syndrome. Three patients had prolonged bleeding times, and in all seven patients whose bleeding times were measured 3–6 months after surgical treatment the postoperative bleeding times were shorter (mean 7.5 min) than the pretreatment times (mean 12.3 min). In ADP‐ or adrenaline‐induced aggregation the second wave was lacking in six and the degree of aggregation was borderline or subnormal in five patients. One patient had, in addition, a severe defect in collagen‐induced aggregation. However, thromboxane B2production of the platelets from both endogenous and exogenous arachidonic acid was unaffected. Factor VIII:C, RAg and Rcof activities were all elevated, and in patients with severe disease F VIIIR:Ag and F VIII:Rcof activities were markedly more elevated than F VIII:C activity. The changes in both primary haemostasis and in factor VIII activities correlated clearly with the clinical severity of the

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1985.tb03254.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY