摘要:

Apoptosis is a common mode of programmed cell death occurring during development as well as in many pathological conditions, in which the cell plays an active role in its own demise. Although the morphological and biochemical hallmarks of apoptosis are conserved across phyla and cell type, the mechanism(s) of apoptosis is unknown. However, data recently published demonstrate that expression of the anti-apoptotic genebcl-2decreases the net cellular generation of reactive oxygen species, and that reactive oxygen species serve as mediators of apoptosis in at least some cases.

ISSN:1071-5762    

DOI:10.3109/10715769409056549

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Glutathione (GSH) was examined with respect to its ability to protect DNA against1O2damage. We have found that GSH protected, at least partly, the DNA against inactivation by1O2. Up to 10 mM the protection increased as a function of GSH concentration. Above 10 mM the protection remained constant and less than expected on the basis of scavenging/quenching of1O2, in contrast to the protection offered by sodium-azide. Especially at the higher concentrations of GSH the protection against the biological inactivation is accompanied by an increase in single-strand breaks and also probably lethal base damage. However, all together the data suggest that at least in the physiologically important range (0.1–10 mM) GSH is able to protect efficiently against1O2-induced inactivating DNA damage.

ISSN:1071-5762    

DOI:10.3109/10715769409056550

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Early reperfusion of an ischemic region can result in significant salvage of the area at risk. We show the presence of hydroxyl free radicals at the time of post ischemia reperfusion using electron paramagnetic resonance (EPR) spectroscopy in a macaque model. These free radicals may be formed as a result of reperfusion or may be an un-involved bystander. It is possible that they may be involved in reperfusion injury.

ISSN:1071-5762    

DOI:10.3109/10715769409056551

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

The activities of superoxide dismutase, catalase and glutathione reductase were not affected byin vitroincubation with the intracellular proteinase calpain, suggesting that these enzymes are notin vivosubstrates of calpain. In contrast, the activity of another important antioxidant enzyme, glutathione peroxidase, is stimulatedin vitroby calpain. This may explain the correlation between elevations in glutathione peroxidase activity and calpain activity which occur in aging, exercised and dystrophic muscle. Calpain treatmentin vitrocaused a large decrease in the activity of carnosine synthetase which is involved in the synthesis of the putative antioxidant carnosine. This may be the reason for thein vivocorrelation between elevated calpain and diminished carnosine levels in aging, hypertensive, denervated and dystrophic muscles.

ISSN:1071-5762    

DOI:10.3109/10715769409056552

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

The effect of antioxidants on ammonia induced CNS and renal pathobiology in 10 sheep infested byL. Cuprinalarvae was investigated. The condition produces severe dermatitis, proliferation of macro-phages and hyperammonaemia, and free radicals may therefore be involved in the pathogenesis. Five of the sheep (treated group) were given daily intramuscular (im) injections of 2 g sodium ascorbate, 5.9 g dl-alpha tocopherol (11 days) and 3 g desferrioxamine mesylate (6 days) with 70 mg oral butylated-hydroxyanisole (11 days). The treatment prevented rises in jugular ammonia, creatinine, urea, sodium and pH, and decreases in water intake, urine output and glucose. The findings showed that antioxidants prevented ammonia induced CNS and renal pathobiology and suggest that free radicals contribute to the pathogenesis of the condition.

ISSN:1071-5762    

DOI:10.3109/10715769409056553

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Proteases, Protease Inhibitors and Protease—Derived Peptides, J.C. Cheronis, J.E. Repine, Birkhauser Verlag AG, Basle, SwitzerlandCytotoxic Cells: Recognition, Effector Function, Generation and Methods, M.V. Sitkovsky, P.A. Henkart, Editors, Birkhäuser Publishing Co., Boston, 1993, 527 pagesThe Handbook of Immunopharmacology Series Editor Clive Page Immunopharmacology of the Heart, Michael J. Curtis, Academic Press: London, 1993, ca $40.00 ISBN 0-12-200245-8 xii + 146 pagesVitamin E: Its Usefulness in Health and in Curing Diseases, Makoto Mino, Haruo Nakamura, Anthony T. Diplock, Herbert J. Kayden, Japan Scientific Societies Press: 1993, $Y13000 ISBN 4-7622-6727-9 xiv + 368 pagesNutritional Toxicology, F.N. Kotsonis, M. Mackey, J.J. Hjelle, Raven Press: New York. Price $170 ISBN 0-7817-0121-X, 1994, xii + 319 pages

ISSN:1071-5762    

DOI:10.3109/10715769409056554

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

ISSN:1071-5762    

DOI:10.3109/10715769409056555

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor