摘要:

SummaryA woman developed generalized symptoms of hypersensitivity when she was stung requiring treatment with adrenalin.Intradermal venom skin tests showed immediate hypersensitivity to yellow hornet and white‐faced hornet thus fulfilling the criteria to receive appropriate venom immunotherapy.During the course of modified rush immunotherapy with yellow hornet and white‐faced hornet venoms, she developed transient but progressive bradycardia necessitating interruption of the venom immunotherapy. Transient bradycardia recurred when venom immunotherapy was resumed but it was possible to reach a maintenance dose of 100 mg protein for each venom.Bradycardia has been reported to be induced in experimental animals by oriental hornet venom as well as other venoms, through a direct cholinergic action. It appears that a similar effect may occur in man in susceptible individuals during venom immunother

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb03130.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySteroid‐dependent, chronic asthmatic patients with severe rhinitis or nasal polyps are often candidates for treatment with intranasal topical corticosteroids, such as flunisolide. The possibility of additive adrenal suppression, when flunisolide, beclomethasone and prednisone are given together, has not previously been studied. The need to assess this risk is suggested by reports of additive adrenal suppression when aerosol and oral steroids are used together to treat asthma, and by the demonstrably higher systemic availability of aerosol steroid given intranasally rather than via the lung. We performed a double‐blind, placebo‐controlled crossover assessment of the efficacy and safety of 3 weeks of intranasal flunisolide spray treatment (300 γg/day) in nineteen steroid‐dependent chronic asthmatic subjects, who also had nasal polyps or severe rhinitis. During the study, their doses of prednisone and beclomethasone, used for asthma, were held stable. Morning serum cortisol levels and 24‐hr urinary‐free cortisol excretion were essentially the same after the placebo, and the flunisolide treatments. The intranasal flunisolide improved their nasal symptoms significantly (P<0.05). Local complications were negligible. Given conventional steroid doses like those used in this study, there appears to be no important risk to endogenous adrenal function from combining the use of intranasal, flunisolide spray with administration of other steroids by other routes, when this is deemed clinically necessary. If higher doses are used, the possibility of some additive adrenal suppressive effect cannot

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb03131.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryA survey of the incidence of allergy in the entire population of a new‐town general practice is reported, comparing the year 1974 with 1979. A rise in the incidence of allergic complaints is noted in both sexes. However, hay fever and asthma continue to show a male dominanc

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb03132.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb03133.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY