摘要:

SummaryOne year after starting work in the pharmaceutical industry a 35‐year‐old non‐atopic maintenance engineer developed attacks of sneezing, coughing and breathlessness. These occurred at home during the evening and early morning, never at work during the day. His employment involved contact with a wide variety of chemical agents including the macrolide antibiotic spiramycin.Inhalation challenge tests carried out in hospital with gradually increasing quantities of spiramycin reproduced his symptoms and led to the development of late asthmatic reactions, during which the FEV1fell by 25% and the FEV1/FVC ratio by 15%. No change occurred in the single breath CO transfer factor nor were crepitations heard over the lung fields which remained normal on chest X‐ray. The patient showed positive immediate skin prick tests to spiramycin and developed blood eosinophilia during the late asthma attacks.Inhalation of sodium cromoglycate either before, or before and hourly after the provocation challenge for 6 hr, failed to prevent the late asthma, although its onset was further delayed.On leaving the pharmaceutical industry the patient's symptoms improved but did not finally clear until his wife, who had worked in a clerical capacity in the same factory also ceased her emp

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01841.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryAttempts to reduce the growth of house dust pyroglyphid mites by vacuum cleaning, and modifications of temperature and humidity are useful but not sufficient. Their absence in dust from hospital beds which are disinfected led the authors to test PARAGERM AK, a non toxic bactericidal and fungicidal spray. This proved highly effective as an acaricide, killing off cultures ofDermatophagoidesspp. and other mites with acceptable arid easily produced concentrations, thus providing a new way of combating the house dust allergy mite.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01842.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Book Reviewed in this article:Monographs in Ailergy Vol. 8. Contact Hypersensitivity in Experimental Animals(1974) Ed. by D. Parkerand J. L. TurkAllergy and Immunology in Children(1973) By FrederickSpeerand RobertJ. DockhornMechanisms in Allergy, Reagin‐Mediated Hypersensitivity(1973) Ed. L. Goodfriend, A. H. Sehonand R. P. OrangeSputum: Fundamentals and Clinical Pathology(1973) By M. J. Dulfa

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01843.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01844.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY