摘要:

SummaryTo study the effects of steroids on the pulmonary lesions in experimental hypersensitivity pneumonitis, rabbits were sensitized to ovalbumin (OA) by injections of OA into footpads and 3 weeks later they were subjected to two successive aerosol challenges with OA at an interval of 48 hr. Injections of hydrocortisone sodium succinate 10 mg twice daily (but not at the reduced dosage of 5 mg twice daily) or methylprednisolone acetate 5 mg twice daily beginning 30 min before the first challenge and continued to the time of killing reduced the extent and intensity of vasculitis in both the treated groups and showed less alveolar septal thickening in the hydrocortisone treated group and less alveolar consolidation in the methylprednisolone treated group compared to the pulmonary lesions in the rabbits which were sensitized and then subjected to OA aerosol challenges, but received no treatment.In view of the observation that even in a steroid sensitive species like the rabbit, extensive pulmonary changes like alveolar consolidation, septal thickening and vasculitis persisted in spite of treatment with relatively large doses of these steroids, it was felt that in human hypersensitivity pneumonitis steroids might only suppress the warning symptoms without substantially affecting the progress of the pulmonary lesions.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01428.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryIn the Caspian Sea region of Iran asthma seems closely related to house dust allergy. Since a high proportion of house dust sensitive patients appear to be sensitive to house dust mites, an investigation was carried out to determine the occurrence, distribution and abundance of these species in Iranian house dust in order to assess their role and clinical importance in house dust allergy in Iran. Thirty‐five samples of house dust collected from houses in the Caspian Sea region and five samples from other areas were examined for mites. The three pyroglyphid speciesDermatophagoides pteronyssinus, D. farinaeandEuroglyphus maynei, reported by European and Japanese workers to be common in house dust and to be a major source of house dust allergens, were found to occur in Iranian house dust and to account for nearly two‐thirds of the total mite population present in the dust.Dermatophagoides pteronyssinuswas the most frequent and most numerous species recorded, occurring in 90% of the samples examined and forming 94% of the pyroglyphid and 60% of the total mite population. The frequency with which house dust mites were found in the Iranian Caspian Sea region coupled with the relatively high frequency of allergic bronchial asthma in this area suggests that they may well be an important precipitating factor in asthma in I

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01429.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY