摘要:

SummaryImmunological release of histamine and lipid mediators is known to occur when basophils, contained in whole blood human leucocytes, are incubated with anti‐IgE (reversed anaphylaxis). In the present study we show that IgE‐dependent stimulation of basophils was associated with activation of bystander eosinophils and neutrophils, as assessed by enhanced complement (C3b) and IgG (Fc) rosettes, and increased cytotoxicity for complement‐coated schistosomula ofSchistosoma mansoni. These changes in eosinophil and neutrophil function were totally inhibited in a dose‐dependent fashion by prior incubation with disodium cromoglycate (DSCG). In allin vitrosystems examined, complete inhibition of enhancement was observed with concentrations as low as 10‐7moles/1. In contrast, DSCG had no effect on histamine release, or the percentage of rosettes or cytotoxicity prior to anti‐IgE stimulation. These results suggest that DSCG inhibits activation of inflammatory cells consequent to an IgE‐depen

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1986.tb01956.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Books reviewed in this article:Sustained Release Theophylline and Nocturnal Asthma, Ed. by A.F. Isles&P. von Wichert.Sustained Release Theophylline in the Treatment of CRAO, Ed. by J.H.G. Jonkman, J.W. Jenne&F.E.R. Simons.Sustained Release Theophylline, a Biopharmaceutical Challenge to a Clinical Need, Ed. by F.W. H.M. Merkus&L. Hendeles.Introduction to Clinical Immunology, M. Haeney.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1986.tb01957.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1986.tb01958.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY