摘要:

SummaryAllergen‐mediated histamine release was measured on small samples of blood in atopic subjects before and following ingestion of two tablets of terbutaline (5 mg) or placebo.No significant variation of histamine release was observed in the placebo group whereas a statistically significant decrease (maximally 45% of basal value) was found in four of the five patients receiving terbutaline. The mean reduction was about 25% of basal allergen‐mediated histamine release. The inhibition was observed 1 hr after taking the drug and persisted for at least 5 hr. Twenty‐four hours later the amount of histamine released by antigen was again at its basal value.These data indicate that terbutaline, at what are considered therapeutic doses, has an antianaphylactic action which might be of interest in the treatment of atopic diso

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb01569.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryWe compared the usefulness of several spirometric measurements in detecting asthmatic reactions after allergen bronchial challenge in fourteen asthmatic children. All of the children had a history suggesting mite‐induced asthma and eleven had a 3 mm or larger diameter weal on prick testing withDermatophagoides farinaeextract. On bronchial challenge testing with dilutions of this extract twelve children had an early asthmatic reaction and nine had a late asthmatic reaction. In decreasing order of sensitivity for detecting the early asthmatic reaction the tests ranked as follows: FEV1, FEF50%, FEF25‐75%, PEFR and FVC. For the late asthmatic reaction the order was FEF50%FEV1, FEF25‐75%, PEFR and FVC. No single test identified all the early or all the late reactions but the FEV1, a test useful for indicating large airways obstruction, when combined with the FEF25‐75%, a test influenced by small airways obstruction, detected all early and late asthmatic reactions. The FEF50%, was a sensitive test but was the only one to become falsely positive. It became falsely positive in four patients. Although the FEV1, was the most useful single test the results suggest that it is, by itself, an inadequate indicator of the asthmatic reaction and that it should be used with the FEF25‐75%, to ensure the detection of all asthmatic reactions induced by allergen bronchial challeng

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb01570.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryA new standardized precision needle which virtually removes operator variation from skin prick testing with allegens is described. The instrument is simple and robust, and the results of its use are demonstrated. The most important finding was that the use of strong pollen extracts produced very inconsistent and irregular weals, but when suitably diluted, or used on mildly sensitive skins, reproducibility of the response was excellent and it is therefore ideal for titration of skin sensitivity and biological assessment of the potency of allergens. The standard needle was also compared with two other methods of skin prick testing. Results were similar but the standard needle showed the least variation.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb01571.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb01572.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY