摘要:

SummaryPrecise and specific radioimmunoassays have been developed to quantify IgG4 and IgG4 antibodies. A community survey has demonstrated that men have significantly higher total serum lgG4 levels than women: geometric mean values of 0.581 mg/ml versus 0.302 mg/ml. This sex difference was extended to total IgE values. Circulating levels of IgG4 antibodies against foods, especially egg‐and milk, were normally higher than those against the three most common U.K. inhalant allergens–grass pollen, house dust mite and cat epithel

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02615.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Summary‘Spontaneous’ improvement in, or alteration of, allergic symptoms is a common occurrence, and the immunological basis is of interest in attempts to develop effective specific therapy. In the present study we measured levels of serum antibodies toDermatophagoides pteronyssinusin patients diagnosed as having house‐dust‐allergic asthma up to 40 years previously. The results show a progressive fall in both IgG and IgE antibodies to antigen P1and RAST binding lo crudeD. pteronyssinusextract. By contrast changes in total serum IgE were not marked. Within each of the groups of patients diagnosed 20. 30 and 40 years previously, 70% no longer suffered severe symptoms. However, the absence of detectable IgE antibody in serum was neither a necessary nor a sufficient condition for loss of symptoms. A group of patients who had spontaneously recovered from hay fever had significantly lower IgG and IgE antibody for the major grass pollen allergen Rye I and also lower total IgE than current hay fever sufferers. In neither hay fever nor asthma was there evidence to link spontaneous improvement in symptoms with an increase in IgG ant

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02616.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryIn children with perennial asthma, dual (immediate and late) reactions in the skin toD. pteronyssinusand Timothy grass pollen were more frequent with high doses of antigen and were associated with large immediate reactions. The frequency of dual bronchial or nasal reactions was not related to the size of the immediate reaction and dual reactions were commonly elicited to the lowest antigen dose which would elicit an immediate reaction. Serum IgG, IgA, IgM or IgE concentrations, IgE or IgG antibodies to the antigens and defective yeast opsonization did not differ in children with dual or immediate only reactions in skin, nose or lung. In five patients undergoing bronchial provocation tests withD. pteronyssinusthere was no fever, no fine crepitations in the kings and no significant change in the levels of C3.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02617.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryThe use of a spray system to coat meat rolls with egg solution resulted in the development of asthmatic type symptoms in eight of thirteen workers exposed to the spray. Symptoms were severe in five workers, less severe in two, and one worker experienced vague symptoms. Even though precipitins were present in nine of the workers there were no pyrexial episodes nor influenza‐like symptoms occurring some hours after inhaling the egg material to suggest extrinsic allergic alveolitis.All sera with precipitins reacted against an antigen in egg yolk, two sera only to this antigen but no precipitins to ovalbumin were detected. Lung function, X‐ray and haematology provided no evidence that the inhalation of egg had lasting detrimental effects.There was no correlation between clinical response, skin testing, IgE levels and precipitins, hence, for each individual none of these parameters is predictive. However, collectively the results show sensitization and this has been confirmed by lack of symptoms when a different method of coating the pastry was adop

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02618.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryA survey of the prevalence of laboratory animal allergy to rats, mice, guinea pigs and rabbits among sixty‐nine animal workers and 308 other subjects on a pharmaceutical research site revealed a 22% prevalence of laboratory animal allergy among the animal workers. The overall prevalence of atopy was 67% in persons with allergy to laboratory animals. This was significantly greater than the 31% prevalence in other animal workers. Skin‐prick tests and specific IgG and IgE assays to urinary protein extracts strongly correlated with the occurrence of laboratory‐animal allergy and would appear to have diagnostic value. However, a number of clinically diagnosed laboratory‐ani‐mal‐allergy subjects gave no evidence of immunological response to the urinary allergens and wider diagnoses may have to be applied in

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02619.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryA cross‐sectional epidemiological study was carried out on 2932 farmers (response rate 92%) living in Northern Italy. A questionnaire on respiratory symptoms was supplied, chest X‐ray taken and simple spirometry tests made. Thirty‐nine subjects reported attacks of breathlessness associated with fever after exposure to mouldy hay; thirty‐six had a clinical history of Farmer's lung and X‐ray and/or respiratory function changes indicative of chronic Farmer's lung; 113 were classified as having bronchial asthma. These 118 subjects and a random sample of 131 non‐symptomatic subjects were examined by intracutaneous skin tests and double diffusion precipitation tests with antigens associated with Farmer's lung. All sera positive by precipitation were examined by immunoelectrophoresis, counterimmunoelectrophoresis, and C1qbinding test, and Bovine conglutinin test in solid phase for the detection of circulating immunocomplexes. 27.8% cases of chronic Farmer's lung, 4.4% of cases of bronchial asthma and 2.3% of non‐symptomatic subjects showed precipitating antibodies against Farmer's lung antigens. Of the precipitin‐positive subjects, the majority had precipitating antibodies againstMicropolyspora faeni.No differences in immunoelectrophoregrams in number and pattern of precipitation arcs forM. faeniwere found between chronic Farmer's lung and bronchial asthma subjects. Circulating immune complexes were present in 50% of chronic Farmer's lung patients, 40% of those with bronchial asthma and 33.3% of non‐symptomatic subjects. Three Farmer's lung subjects (9.3%) showed immediate skin‐test reactions to rural envi

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02620.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryPrecipitins against avian antigens in sera from patients with extrinsic allergic alveolitis, asymptomatic pigeon and chicken breeders and from control individuals were tested with different antigen extracts in six laboratories by a variety of different methods. Eighty percent of the results coincided in identifying the positive sera from patients and 90% in identifying the controls. It seems possible therefore to exchange results among experienced laboratories with fair confidence.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02621.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummarySix out of eight patients with a history of aspirin‐provoked urticaria/angioedema responded with adverse reactions, including urticaria and bronchospasm, to provoking doses of oral aspirin from 30‐515 mg. The other two patients did not react to 1.2 g of aspirin on three occasions. Five of the six patients who had reacted became desensitized after their initial aspirin reaction, tolerating 650 mg on the second day. They then took 650 mg day−1of aspirin for three weeks, during which time the ingestion of foods which had previously caused a variety of moderate or severe reactions caused no symptoms. The resting plasma PGF2αin ten ‘aspirin‐sensitive’ urticaria patients (24.89 + 2‐79 pg m−1) was significantly higher than the levels in ten normal subjects (6.75 + 1‐1 pg ml−1) (P<0.01). In the patient group the lowest levels of PGF2xwere found in the two patients who subsequently did not experience a positive reaction after aspirin provocation. The PGF2α/PGE2ratio in ‘aspirin‐sensitive’ urticaria patients (1‐83 + 0.026) was significantly higher than that in normal su

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02622.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryAllergy skin testing of infants and small children continues to be time‐consuming and nerve‐wracking. We hoped to have found the solution to these problems by using the multi‐test (MT). The latter consists of an applicator with 8 heads, each head consisting of nine plastic needles on which the allergen solution rests. Thus eight allergens can be tested simultaneously. During routine control skin testing we compared MT with our usual method, the prick test (PT), amongst twenty patients. Twenty‐seven percent of the skin reactions differed by more than 1 +. When we compared PT results with the previous PT, the correlation of 16% was better despite several years interval between tests, different persons carrying out the tests, and hyposensitization of patients. We adapted the MT system and produced a model, multi‐test 2 (MT‐2), which consists of eight sterile disposable needles on a stainless steel base. When we compared the MT‐2 with PT, only 6% differed by more than 1 +. Thus the MT‐2 proves to be a useful alternative to the PT for those children, in whom the PT is too difficu

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02623.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryAllergens ofOlea eurupeahave been prepared by isoelectrofocusing and tested by RAST, RAST inhibition and skin tests. The major allergen was found to be an acidic protein of pI 6, consisting of two polypeptide chains of molecular weight 15000 and 17000 daltons, possibly non‐covalently associated into a dimer. Most other allergens were acidic proteins, but basic proteins were also observed with allergenic activity. The RAST inhibition studies show a considerable degree of allergic cross‐reactivity between the isoelectrofocusing fracti

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02624.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY