ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00284.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00285.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00286.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryHistamine‐induced food intolerance is not IgE‐mediated. Skin‐prick testing and specific IgE to food allergens are typically negative. Food rich in histamine or red wine may cause allergy‐like symptoms such as sneezing, flush, skin itching, diarrhoea and even shortness of breath. The suspected reason is a diminished histamine degradation based on a deficiency of diamine oxidase. As diamine oxidase cannot be supplemented, a histamine‐free diet was implemented to reduce histamine intake. Forty‐five patients with a history of suffering from intolerance to food or wine (n=17) and chronic headache (n= 28) were put on the diet over months to years. Fish, cheese, hard cured sausages, pickled cabbage and alcoholic beverages had to be avoided. Complaint intensity and drug‐use per week prior to and 4 weeks after a histamine‐free diet were compared. After 4 weeks on the diet 33/45 patients improved considerably (p<0.01), eight of them had total remission. In 12/45 patients, however, no changes in symptoms were observed. Symptoms of food or wine intolerance significantly decreased (P<0.02; treatment of choice), headaches decreased in frequency (P<0.001), duration and intensity. After eating histamine‐rich food symptoms were reproducible and could be eliminated by anti‐histamines in most patients. These data indicate the role of histamine in food and wine intolerance and that histamine‐rich food causes a worsening of symptoms in patients suffering from chronic headaches. Results obtained support the hypothesis of a deficiency of diamine oxidase in patients with intole

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00287.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryThirty‐nine children with grass pollen hay fever were randomly treated with nasal inhaled beclomethasone dipropionate (BDP) 200 or 400μg‘day or sodium cromoglycate (SCG) 30 ing/day for 2 months during the pollen season. Scrum osteocalcin (OC), parathyroid hormone (PTH). total alkaline phosphatase (AP). hone alkaline phosphatase (BAP) and type I collagen telopcptide (ICTP) were measured immediately before, I and 2 months after treatment and 1 week after stopping the therapy. No significant changes in OC, PTH, AP, BAP and ICTP serum level occurred within each group. Minor and probably clinically insignificant between group differences were occasionally found. Our study shows that BDP nasal spray has no significant effect on common markers of bone metabo

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00288.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummarySpontaneous histamine release (SHR) in whole blood was assessed before and after 4 months of specific immunotherapy (SIT) for allergic rhinoconjunctivitis in 32 patients. Spontaneous histamine release was significantly enhanced (P<0.05) in patients prior to immunotherapy compared with 20 controls. Spontaneous histamine release decreased significantly in patients after 4 months of specific immunotherapy (P<0.04) and almost reached the same values as spontaneous histamine release in controls. Clinical success of treatment after 4 months was seen in 15 patients (improvement 50%), 10 of whom showed a significant decrease in spontaneous histamine release. Decrease of spontaneous histamine release after 4 months indicates the efficacy of specific immunotherapy already at an early stage of treatment. Assessment of spontaneous histamine release appears to be a useful and easily performable method for monitoring success of treatment of patients during specific immunotherapy.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00289.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryType I hypersensitivity to pistachio nut antigens was demonstrated in three patients by means of immediate skin‐test reuctivily. specific IgF determination by a lluoro‐immunoassay (CAP). CAP‐inhibition and leucocyte histamine release. Sensitization to other dried fruils and pollens was observed in the patients. The CAP‐inhibition studies revealed signilicLint crossreactivity between pistachio and cashew nut belonging to the Anacardiaceae family, and between pistachio nut and other dried fruits belonging to taxonomically unrelated botanical families. No relevant crossallergenicity was observed between pistachio nut and Lolium and Olca pollens.Sodium dodecyi sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) of a pistachio nut extract followed by immunoblotting analysis identified four IgE‐binding bands with molecular weights of 34. 41.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00290.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryThe involvement of platelet activating factor (PAF) in antigen‐induced bronchial hyperresponsiveness was investigated by the use of the PAF antagonists BN 52021 and BN 50730, in a guinea‐pig model where sensilization and challenge were performed by aerosol. Male Hartley guinea‐pigs were sensitized by two aerosol exposures at 48 hr intervals to a 0.9% NaCl solution (saline) containing 2 mg/ml ovalbumin lor 30 min. Fifteen to 20 days later, guinea‐pigs were challenged by exposure to five successive aerosols ofincreasing concentrations of ovalbumin (OA) or respectively, 10 μg ml. KM) μ/ml, 1 mg/ml. 5 mg/ml and 10 mg/ml for 15 min each, orsaline alone. Three to four hr and 18‐24 hr after the aerosol challenge the guinea‐pigs were prepared for recording of bronchopulmonary response and aerosol administrations were then generated with an ultrasonic nebulizer. The bronchopulmonary responses induced by successive I‐min aerosol bursts of acetylcholine(ACh) was assessed. As compared with saline‐challenged guinea‐pigs, an enhanced bronchopulmonary response to aerosol administration of cumulative doses of ACh was observed, 3 4 hr and 18 24 hr post‐ovalbumin challenge. When the sensitized guinea‐pigs were pretreated I hr before ovalbumin exposure with BN 52021 or BN 50730 (25 mg/kg,per ox), a significant inhibition of the increase in the bronchopulmonary response to ACh was observed, both at 3–4 hr and 18–24 hr. Furthermore, when guinea‐pigs were treated 3–4 hr after the ovalbumin exposure with BN 52021 or BN 50730, a significant inhibition of the hyperresponsiveness to ACh was recorded at 18 24 hr. A marked accumulation of eosinophils in the peribronchial regions was observed on histological preparations of lung specimens collected 4 hr or 24 hrafler ovalbumin exposure. Pretreatment of the guinea‐pigs by BN 50730 or BN 52021 did not modify the eosinophil accumulation in the peribronchial area. No significant difference in the number of eosinophils collected in the bronchoalveolar lavage fluid is observed, 24 hr posl‐ovalbumin challenge, under the pretreatment with BN 52021 or BN 50730. Pretrealment of guinea‐pigs by BN 50730 or BN 52021 significantly reduced the PAF‐induced (100μg/ml) increase in eosinophil number in the peribronchial area. By contrast, they did not inhibit the eosinophilia induced by aerosol administration of LTB4(5 μg/ml). These results suggest that the bronchial hyperresponsiveness observed in this study is associated with eosinophil accumulation in the lung. The potent inhibition of the bronchial hyperresponsiveness by the two unrelated antagonists of PAF suggests that the lipid mediator is involved in its triggering and duratio

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00291.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00292.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryHistamine plays a key role in the pathogenesis of chronic urticaria (CU). The authors of this paper have studied the effects of ingested histamine in 25 patients with CU. A 120 ing dose of histamine. well‐tolerated in the healthy subject, was instillated into the duodenum. Concomitantly. plasma histamine (H) levels and plasma and urinary methylhistamine (MH) levels were measured. Intraduodenal administration of histamine was responsible for the development of an attack of urticaria in 64% of patients, while control subjects were asymptomatic. Plasma histamine levels were significantly higher after digestive histamine challenge (DHC) in patients with CU compared with controls. An abnormal increase in plasma histamine was observed in 72% of them. Plasma MH exhibited the same kinetic behaviour with a usually delayed time‐pattern. Urinary MH concentration was higher in patients presenting with early‐onset urticaria during the first hour than in those with the late‐onset type between 1 and 12 hr after DHC. The coefficient of mcthylation (plasma MH/MH + H) was not significantly different in patients presenting with an attack of urticaria following DHC and in other subjects, Urinary excretion of MH and urinary flow increased significantly in patients presenting with an attack of urticaria following DHC which corresponds to increased absorption of histamine during the 5‐hr period following DHC and its role on excretion by the kidney via vasodilation which it induces. This study demonstrates the abnormal frequency of disturbances in the metabolism of exogenous histamine in patients with CU. Increased plasma H accounts for the abnormal passage of H across the intestinal barrier which can result either from intestinal hyperpermeability and/or a deficit in the enzymatic catabolism of histamine. The systems of methylation and urinary clearance of MH appear to be effective. It is thus postulated that there is a deficit in diamine oxidase (DAO) in the enterocyte. The lack of correlation between the kinetic behaviour of plasma H and the onset of urticaria draws attention to the extent of individual variability in skin reactivity to

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1993.tb00293.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY