摘要:

SummarySera from patients with allergic asthma to castor bean dust were tested for specific antibodies in the red cell linked antigen‐antiglobulin reaction (RCLAAR) using antiglobulin sera specific for IgE and the four subclasses of IgG. Approximately one‐third of the patients with specific IgG antibodies had an antibody response that was predominantly in the IgG4 subclass. Two patients who were thought not to be sensitive to castor bean allergen, despite long exposure to the dust, did not have detectable IgE antibodies, but had high titres of IgG antibodies that were predominantly IgG4. Specific IgG4 antibodies to castor bean allergen were heat stable, did not appear to passively sensitize monkey skin in the PCA reaction and did not passively sensitize human basophils for the rosette reaction with castor bean‐coated red

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01874.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummarySpecific IgE antibodies were determined on a routine basis in patient sera using the radicallergosorbent test (RAST) with a panel of ten common allergens. Total IgE was also assayed. Of all positive RAST reactions observed, 74% were against the following allergens: horse and cat epithelium, birch and timothy pollen, and house dust. Clustering (occurrence together with significantly elevated frequencies) accompanied both positive reactions to some animal danders and food allergens. Children in all age groups had significantly more positive food RAST results than adults, and this explains the clustering among food allergen results. Children aged 0–4 years had few positive pollen results. Among those with at least one positive RAST result, the mean number of positive results was 3.3, a figure which did not vary with age. In the present patient population 37% had a total IgE above the upper reference (normal) limit, and of these 95% had at least one positive RAST result. A normal or low IgE value was found to be less informativ

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01875.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryThe relationship between seasonal asthma and sensitivity to the house‐dust mite has been investigated in a country with large seasonal variations in relative humidity.Of seventy‐eight African asthmatics, 64.1% gave a history probably suggestive of sensitivity to house‐dust, and 55.1% a history strongly suggestive of such sensitivity. On skin testing, 35.9% had strong reactions to the house‐dust miteDermatophagoides Pteronyssinus, compared with 1.9% of fifty‐one matched controls without symptoms of chest disease. Few had either a history or skin tests suggestive of pollen or mould sensitivity. Most of the asthmatics were worse during the hot, wet season when the humidity is highest. This is also the time when in‐patient asthmatics are most numerous.D. pteronyssinusgrows well in warm, damp conditions and it is suggested that sensitivity to this mite may play a significant role in the marked seasonal changes seen in our asthmat

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01876.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryBetamethasone valerate nasal aerosol in a daily dose of 400 μg was compared with a placebo in a double‐blind trial involving 103 patients with summer hay fever. The patients ‘and physicians’ preference for the active compound was statistically significant (P<0.001), with 88% of the patients receiving betamethasone valerate obtaining substantial relief of symptoms. The analysis of patients' daily symptom scores showed that nasal symptoms were significantly reduced by the active aerosol (P<0.001). A day‐by‐day comparison of nasal symptom scores with pollen counts indicated a decreasing allergic response as the season progressed; possible reasons for this are discussed. No clinically significant side effects were observed. Short tetracosactrin tests from ten randomly chosen patients on betamethasone valerate showed no abnormality and nasal swabs for Candida culture from a further thirty‐two patients were negative. It is concluded that intranasal betamethasone valerate is an effective and safe form of therapy for seaso

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01877.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryThirty‐four beekeepers were interviewed and their blood assayed for the presence of antibodies reacting with bee venom, bee venom phospholipase A (PLA), and whole bee body extract. Following a bee sting, most beekeepers experienced only minimal local tissue reaction. Their serum contained high levels of total antibodies (primarily IgG) reacting to bee venom and phospholipase A. These antibody titres correlated with the frequency of bee stings.Bee venom and PLA specific IgE antibodies were present in serum of some beekeepers. Beekeepers who had experienced allergic reactions were characterized by low total antibody and high venom specific IgE antibody titres. Bee body IgE antibodies were found in varying degree and did not correlate with levels of venom IgE antibodies. There was no difference in the titres of bee body IgE in the sera of beekeepers with and without systemic reactions.The data suggest that allergic reactions are mediated by venom specific IgE and immunity is at least in part a function of other antibodies, probably primarily Ig

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01878.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryClinical observations and immunological evidence are presented to support a diagnosis of late onset asthma due to exposuretoAspergillus nigerin a 70‐year‐old man. Asthma occurred on only three occasions, each time approximately 6 hr after exposure to an area containingAspergillus niger. His sputum culture contained the same organism. Immunological correlates using theAspergillus nigerextract included positive immediate and late skin tests, histamine release from leukocytes, and serum precipit

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01879.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryA serological comparison was made of two groups of 120 matched asthmatic and healthy subjects, between the ages of 20 and 49 years and matched for age and sex, in terms of serum total levels of IgG, IgM, IgA. IgD and IgE and of specific antibody levels in each immunoglobulin class to five common UK allergens. The relationship of clinical features to the serological tests was also examined in the asthmatic subjects.The following statistically significant findings were shown. The patients had higher levels than the controls of total globulins and of IgG, IgA and IgD but not IgM. In both patients and controls the females had higher IgM levels than the males. The total IgE levels were higher in patients than in the controls and the male patients had higher levels than the female patients. Total IgE levels were also related, to the numbers of first degree relatives with asthma, hay fever and eczema, to the severity of hay fever and to the amount of time off work in the male patients. In those male patients with exercise induced asthma the total IgE levels were lower than in those not showing this reaction.As for the other iminunoglobulins, the only significant differences were a higher [gG level in patients with FEV, or PFR>50% predicted and a higher IgD level in patients with hay fever. Radio‐immunodiffusion tests for specific precipitins were positive forDermatophagoldes pteronyssinusin comparable numbers of asthmatics (25.8%) and controls (21.7%). Positive precipitin tests were uncommon in tests with extracts of grass pollen,Aspergillus fumigatus, cat and dog hair in the patients and even less so in the controls. Positive RAST tests for specific IgE antibodies were obtained in patients and controls respectively, againstD. pteronyssinus59% and 11% grass pollen 37.0 and 12%, andA. fumigatus6% and 4%.The male patients showed the closest significant relationship of specific IgE toD pteronyssinusand the history of house dust allergy, positive skin test and nasal test. in the females only the skin and specific IgE tests were related. Both sexes showed a significant association between specific IgE to grass pollen and positive skin tests and nasal tests, but only the males showed an association with the history. The size of skin test weal toD. pteronyssinuswere related to the levels of specific IgE antibody, Correspondence: Professor J. Pepys, Cardiothoracic Institute, Brompton, London SW3 6HP.No differences were found between the four skin test groups and between the asthmatics and the control subjects in the incidence of bacterial precipitins and auin‐antibod

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01880.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryAmong fifty‐three Salt Lake City. Utah area pigeon fanciers, 21% were found to have the clinical picture of pigeon breeders disease. This is a much higher frequency than has been observed previously. Abnormal spirometry and increased skin reactivity to pigeon sera were found more often, statistically significantly, in symptomatic than in exposed asymptomatic fanciers. Pigeon breeders' disease is associated with a variety of abnormal findings; skin test, precipitins, pulmonary function changes and radio‐graphic derangements: but unfortunately none of these are diagnostic. Pigeon breeders' disease is best identified by clinical crite

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01881.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryA comparison of the RAST (Phadebas®), skin prick test, nasal test and a history of hay fever was made in 141 subjects, eighty‐seven being prick test positive, with three concentrations of extracts of Sweet vernal (Anthoxanthumodoratum), Cocksfoot(Dactylis glomeratd), Meadow fescue(Festuca elatior), Rye (Lolium perenne), Timothy (Phleum pratense), Meadow (Poa pratensis). In adequate concentration any of the species extracts would have sufficed for skin tests, with Cocksfoot pollen the most potent. Correlations found were: positive RAST/prick test, 98%; positive prick test/ RAST, 89%; positive RAST/nasal test, 75%, and the higher the RAST the closer the correlation and the higher the nasal sensitivity; nasal test positive/RAST negative, 17%; positive history/RAST, 91%; positive history/prick test, 9

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01882.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SummaryIn a research assistant with recurrent episodes of extrinsic allergic alveolitis on exposure to rats, typical systemic and pulmonary reactions on inhalation and positive reaction on prick testing were elicited only by tests with rat serum; precipitins were present against rat serum and rat pelt, but not rat fur, and were also present against rat urine, which may contain large amounts of serum protein and which may haw been a main source of antigenic exposure.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1975.tb01883.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY