ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00841.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00842.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00843.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00844.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00845.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00846.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryA radio immunoassay was developed allowing measurement of the cytotoxic cationic ECP. The assay, which has a total incubation time of 3.5 hr, is a double antibody assay with radiolabelled ECP. covering the concentration range of 2–200 μ/l. Performance data show a detection limit of<2 μg/1 and a cross‐reactivity with eosinophil protein X (EPX/EDN) of<0.06%. The coefficient of variation (%) within the measuring range was, within assay 4.8–10.4, and total 6.6–12.0. The assay is useful for measurement in various body fluids including serum, nasal secretions and bronchoalveolar lavage fluid, and dilution of samples prior to analysts was generally not required. Sera from 100 apparently healthy individuals revealed a geometric mean of 6.0 μg ECP/1 and a range (95%) of 2.3–15.9 μg/1. The elimination rate of ECP, t12.in vivowas estimated to be 65 min when ECP was measured in serum. Comparisons between this assay and a method previously described showed that the new method is superior with regard to precision and as

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00847.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryTwenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double‐blind cross‐over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross‐over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry‐over effect in the active‐placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food in

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00848.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryIn order to examine further the relation between atopy, as denned by skin‐prick tests, and respiratory illness, we studied three populations of schoolchildren aged 8–11 years and living in different climatic areas of New South Wales, Australia. Skin‐prick tests were performed using 13 commercial allergen extracts. Respiratory and allergic symptoms were assessed using a self‐administered questionnaire to parents and bronchial hyper‐responsiveness (BHR) was measured by histamine inhalation test. We defined current asthma as BHR together with symptoms of wheeze in the 12 months prior to study. Children with one or more positive skin weals of 3 mm had significantly more recent wheeze, hayfever, eczema and BHR than children with smaller weals (P<0.001). In each area, 95–97% of all atopic children were sensitized to one of the following seven allergens: house dust,Dermatophagoidesfarinae, D. pteronyssinus, cat dander, plantain, rye grass, andAlternaria tenuis. Thus, these seven selected allergen extracts and a skin weal of 3 mm could be used to detect clinically relevant atopy in these populations of children. Sensitivity to house dust mite had the strongest independent association with current asthma in all three areas. The associations of other allergen sensitivities with BHR or current asthma were area dependent, indicating the influence of local allergen levels on respiratory illness in children. The potency of house dust mite sensitivity in increasing the risk of children having BHR and current asthma i

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00849.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryWe examined unilaterality of obstruction after acute bilateral nasal allergen provocation in two groups of pollen‐sensitive volunteers studied out of season. One group was challenged on one occasion with a threshold allergen dose and on another with placebo. We measured nasal airway resistance (NAR) unilaterally for 3.5 hr before the challenges and for 40 min after. Most subjects' noses had marked asymmetry of response. Over half showed marked obstruction on one side and none at all on the other side. The side which showed higher resistance and greater lability before challenge was typically more obstructed after. In a second group we compared responses to threshold and × 10) threshold doses. Threshold challenge produced results similar to those seen with the first group. After the higher allergen dose, there was some obstruction in the less responsive side and the rate of rise was much slower. Obstructive response after acute threshold allergen challenge is typically one‐sided. This pattern may be related to the stage of the nasal cycle in which the challenge was delivered. Higher allergen doses produce more obstruction in the less responsive side but the response is still asymmetr

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1991.tb00850.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY