摘要:

SummaryThe incidence and characteristics of P1‐antibodies in Scottish pigeon fanciers has been assessed. Of 223 individuals participating in the study, 23.3% were P1‐negative and of these, 53.9% had detectable P1‐antibodies. These antibodies were shown to belong to the IgM class and the highest serum levels were found in those pigeon fanciers with symptoms of respiratory disease who were sensitized to pigeon antigens. Of pigeon fanciers'; sera, 10.3% gave false positive reactions for the Hepatitis B surface antigen in a reversed passive haemagglutination test. The reactions were most prevalent in sensitized fanciers and were shown to be directed not against the absorbed HBsAg antibody, but against the turkey red cells used as carriers in the test. No relationship was observed between the existence of P1‐antibodies and false‐positive hepatitis reactions. It was concluded that the inhalation of avian antigens by pigeon fanciers can induce the production of at least three distinct populations of antibodies. No evidence was obtained to imply any special role for P1‐antibodies in the aetiology of pigeon fancie

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02147.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryFifteen children, 6–14 years old, who were heavily exposed to pigeon droppings, presented with cough, chills and breathlessnes on mild exertion. Twelve gave immediate positive skin test reactions to pigeon droppings. Ten of the fifteen also gave a late (Arthus) reaction, and seven gave a positive delayed reaction which was maximal at 24–72 hr. Nine children had precipitins against avian droppings. In ten patients who were tested for lymphocyte transformation, five gave positive responses to both serum and pigeon droppings. Radiological findings of the chest showed parenchymatous infiltrations and diffuse interstitial reticulations, suggestive of extrinsic allergic alveolitis. In a control group of fifteen heavily‐exposed children who had no symptoms, immediate and late skin reactions occurred respectively in five and two. One only had a positive precipitin test, and one of five tested had a positive lymphoblastic transformation. In a non‐exposed comparable group of children, all tests were negative except for one immediate positive skin response. Children heavily exposed to the inhalation of avian antigens can develop extrinsic allergic bronchiolo‐a

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02148.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryWe evaluated 587 cases with generalized reactions to stings of Hymenoptera. Eighty of these patients and twenty‐eight normal controls had radioallergosorbent tests (RAST) to venoms of honey bee, yellow jacket, hornet, wasp and to phospholipase A. Those patients with systemic reactions had a significantly greater frequency of positive RAST than normal controls (51.3%vs.7.1%,P<0.001). The frequency of atopy (asthma/rhinitis) in these 587 cases was only 22% and resembled the expected frequency in a general population. Asthmatic patients did not have an increased risk of developing systemic reactions to Hymenoptera stings. However, those asthmatic patients with systemic reactions to Hymenoptera stings had a significantly more severe anaphylactic reaction to a sting than non‐asthmatics. These severe reactions were primarily manifested by acute dyspnoea, which appeared to represent a bronchospastic response to endogenous histamine rele

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02149.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryRAST to venoms were done on 108 sera. Positive RAST to one or more venoms of Hymenoptera found in 51% (41/80) patients with a generalized reaction to the sting of Hymenoptera and in 7% (2/28) of normal controls were critically evaluated. RAST determinations for each sera were done in duplicate and results averaged. The laboratories were not told which sera belonged to patients with allergy to Hymenoptera and which belonged to controls. In ten patients, one half of the original sera were saved and RAST to venoms were repeated approximately 1 years later. Of our positive RASTs, 49% (20/41) had positives to more than one type of venom. The most frequent positive RAST was to yellow jacket followed by hornet, wasp, and honey bee. A high degree of cross‐reactivity occurred between venoms of hornet, wasp, and yellow jacket. The frequency of positive RAST was similar in pre‐treatment and post‐treatment sera from patients on immunotherapy with whole body extract. Specific IgE (RAST) results to venoms did not correlate with the degree of clinical severity of the sting. However, IgG anti‐venom antibodies were not considered. Elevated RAST titres were associated with increased total IgE levels in sera of non‐atopic patients. A positive RAST to venoms is frequently found in sera of patients stung within 5 years. RAST scores of 2 to 4 were remarkably reproducible, while scores of 1 were not consistently reproducible. RAST results should be interpreted in conjunction with the clinica

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02150.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryOf 317 patients with hypersensitivity to Hymenoptera stings forty had severe local reactions (SLR) only, fifty‐nine reported severe local reactions before their first and seven after their last systemic reaction (SR). The probability to develop a life threatening systemic reaction when restung after a severe local reaction was calculated to be about 5%. In 80% of the patients with severe local reactions only, hypersensitivity to either bee or yellow jacket venom could be demonstrated by skin tests and/or RAST. A fair correlation of skin test and RAST results was observed. In patients with severe local reactions hyposensitization therapy with venoms is not generally indicated. In exceptional patients whose allergy is proven by skin tests or RAST and who are at a high risk of being restung, hyposensitization may be considere

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02151.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe effect of tartrazine (T) (yellow dye No. 5) and one of its metabolites an aminopyrazolone analogue (1‐sulphophenyl‐3‐carboxy‐5‐hydroxypyruzole, SCHP) upon collagen‐induced platelet aggregation (C‐PA) was investigated in fourteen atopic patients and fourteen normal subjects. Both T and SCHP inhibited C‐PA in atopic patients at significantly lower doses than in normal volunteers. The mean inhibitory concentrations of SCHP were similar to aspirin in both atopic and normal individuals. Although the precise mechanism by which these chemicals block C‐PA has not been elucidated, thisin vitrosystem may be a useful method of assessing non‐immune mechanisms involved in reac

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02152.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryWe studied the stimulation of lymphocytes in 258 patients with urticaria and/or angioedema using a series of food extracts and additives. Of this group, 238 revealed a positive response index (RI). There was a positive RI to additives in 18.4% of the cases, to food extracts in 35.2% and to both extracts and additives in 46.6% of the cases. A positive RI to both aspirin and tartrazine was revealed in 25% and to all the additives tested in 11% of the cases.Diets from which food extracts and additives were excluded achieved total remission in 159 (61.1%), partial remission in fifty‐seven cases (22%) and no remission in forty‐two (16

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02153.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe role played by dietary chemical factors in the pathogenesis of chronic idiopathic urticaria (CIU) was assessed in seventy‐six patients by challenge. Stable remission was first established by using an empirically established ‘exclusion diet’. A diet modified to exclude those chemicals giving a positive response to challenge was demonstrated to be of therapeutic value for time periods of up to 18 months. Re‐testing twelve patients at 12 months indicated that most patients positive to salicylate or benzoate challenge retained this pattern of rea

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02154.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThein vitroeffect of levamisole (LMS) on lymphocyte, neutrophil, basophil and platelet function was investigated in patients with severe atopic dermatitis and hyper‐immunoglobulinaemia E. Lymphocyte stimulation by several concentrations of PHA, con A and PWM, polymorphonuclear leukocyte chemotaxis and basophil histamine release were unaffected by LMS (10 μg/ml). Platelet serotonin release induced by iodipamide was decreased in patient and control groups by LMS but release induced by methacholine, epinephrine and thrombin was n

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02155.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe efficacy and safety of a new orally‐active chromone, proxicromil, has been assessed in a single‐blind controlled study in perennial extrinsic asthma. Patients entered into the study were currently requiring treatment with sodium cromoglycate (Intal; Lomudal) which was confirmed by deterioration of their asthma when changed to a placebo preparation of identical appearance. Proxicromil was administered for two consecutive 3‐week periods using a dosage regimen of 18 mg twice per day for the first period followed by 18 mg four times per day for the second period. Patients improved during the 6 weeks' treatment with proxicromil. This improvement could be detected by the majority of patients by the end of the first week. When patient treatment was changed to a corresponding placebo for a final period of three weeks their asthma deteriorated. No abnormal laboratory findings of significance were detected on haematological, liver function or urinalysis examination. The side effects noted relate mainly to gastro‐intestinal disturbances and generally were of a mild

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02156.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY