摘要:

SummaryA radio‐allergosorbent test (RAST) to measure specific IgE antibodies in man to whole bacterial cells ofStreptococcus pneumoniae,StaphylococcasaureusandHaemophilus influenzaewas developed to investigate different well‐defined lung diseases (chronic bronchitis, allergic bronchopulmonary aspergillosis (ABPA), bronchial asthma, allergic rhinitis, cystic fibrosis) and also in urticaria as compared with non‐atopic blood donors, in addition, total IgE values and skin prick tests were assessed in these patients.The ABPA group gave the highest specific IgE RAST scores to all three bacteria. whilst the chronic bronchitis and cystic fibrosis groups also gave raised RAST scores withH. influenzae.There was a positive correlation between the patients'Sta. aureusandStr.pneumoniaeimmediate‐type skin reactions and their RAST scores and total serum IgE concentrations, but there was only a low incidence of immediate‐type skin test positivity toH. i

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01642.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryLeucocytes from normal non‐allergic donors were passively sensitized with sixty‐five atopic sera that contained IgE directed against house dust mite (HDM) or guinea‐pig dander (GPD). In no serum was there any IgE with an abnormal basophil anaphylactic‐sensitizing activity.In sera from patients hypersensitive to GPD, both GPD‐specific IgE and IgG4 were measured. A significant correlation was found between the GPD‐IgE RAST and the basophil‐sensitizing capacity of GPD‐positive sera, but no correlation was found between this sensitizing capacity and the GPD‐lgG4 RAST.Leucocytes were passively sensitized with serum mixtures that contained the same amounts of total and HDM‐specific IgE; these mixtures differed as to sensitizing activity. It is unclear whether this variation is due to differences in IgE or to influences of oth

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01643.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySerum total and allergen‐specific IgE and IgG4 antibodies, were measured in eighty‐seven atopic and nineteen non‐atopic asthmatics. The allergens studied were: Dermatophagoides pteronyssinus, grass pollens, cat dander, dog dander, milk and egg. Sixty‐eight atopic asthmatics and fourteen non‐atopic asthmatics were found to have allergen‐specific IgG4 antibodies, to at least one of the allergens tested. IgG4 antibodies to milk and egg were common in both groups of asthmatics, and to animal danders in the non‐atopic asthmatics.Skin prick tests were always negative when allergen‐specific IgG4 antibodies occurred alone, but in such cases, intradermal skin tests were positive.Seventy‐five per cent ofa group of patients with normal levels of serum total IgG4, were found to have at least one p

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01644.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySkin tests with histamine, the histamine‐liberator, codeine, and various allergens as well as blood basophil degranulation by anti‐IgE or anti‐IgG4 and total serum IgE levels have been studied in two female populations of different ages (average 23‐1 and 73‐9 years). All thirty‐one patients selected for this study were clinically non‐allergic.We observed a trend towards reduced skin reactions to histamine and codeine in the higher age‐group; on the other hand, we could not find any decrease of basophil degranulation as a sign of basophil impairment with age. Likewise no difference in total serum IgE levels have been noticed.No correlation between skin tests and basophil degranulation was observed; yet patients with isolated, positive skin tests to house dust and/orCandida albicansshowed a statistically significant reduced blood basophil degranulation by anti

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01645.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryT lymphocytes were separated from the bronchial mucus of five patients with extrinsic asthma and chronic mild bronchitis and who had numerous eosinophils in the bronchial mucus but no significant blood eosinophilia. The bronchial lymphocytes spontaneously, that is without treatment with antigens or mitogens, released into serum‐free synthetic medium one or more substances in the molecular weight range of 30 000 to 60 000 daltons. These substances when tested on eosinophils of normal persons stimulated random movement (chemokinesis), attracted them (chemotaxis), enhanced their chemotactic response to activated complement, and increased the expression of C4 and C3b receptors. Chemokinetic and chemotactic activity for neutropils was weak. No eosinophil‐stimulating activity was found in cultures of bronchial lymphocytes treated with puromycin to inhibit synthesis. The blood lymphocytes did not spontaneously synthesize the substance(s).It is not known if the several eosinophil‐stimulating activities are due to one or more substance(s), but the nature of the eosinophil responses, molecular weight and other features, indicate similarities with the ‘eosinophil stimulation promoter‐chemotactic’ factor reported to be released from mouse or human lymphocytes treated with antigen.Eosinophil stimulation resulting in increased expression of specific receptors, and potential for non‐specific adherence, by trapping or arresting randomly migrating cells, is believed to mediate accumulation of cells in an affected organ. Prolonged synthesis of such products, as from activated lymphocytes in the lung, could account for much of the local

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01646.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryIn order to study the clinical significance of late cutaneous allergic responses 178 intracutaneous tests were done on the forearm of forty‐three allergic patients with perennial allergy and twelve patients with pollen allergy. The allergen concentration was chosen to give a moderate immediate response with a weal diameter of about 15 mm. Late cutaneous allergic responses (LCAR) were elicited in eighty‐two intracu‐taneous tests in thirty‐one patients with perennial allergy and in nine intracutaneous tests in eight patients with pollen allergy, with almost all the allergens Frequently responsible for allergy in this area. Their occurrence was found to be related to the size of the immediate reaction. Almost all the patients showing LCAR had positive provocation tests and were clinically sensitive to the corresponding a

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01647.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryAllergen‐specific IgA and IgE antibodies were compared in 250 children with asthma (Dermatophagoides pteronyssinus, rye grass pollen), in eighty‐six children with eczema (whole egg, cow's milk) and in two groups of children with egg and cow's milk allergy.In each of the conditions investigated, food allergy, asthma and eczema, increasing atopy was associated with increasing specific IgE levels to relevant allergens.There was no association of high IgE antibody levels with low IgA antibody levels in any of the conditions or allergens studied. There was, however, a tendency for subjects with more severe asthma to have high IgA levels with high IgE levels. IgA deficiency does not appear to be associated with atopic conditions of childh

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01648.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01649.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01650.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1982.tb01651.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY