摘要:

SummaryTwenty patients with atopic eczema were compared with twenty non‐atopic healthy controls. The atopic patients had significantly reduced percentages of lymphocytes bearing receptors for the Fc fragment of IgG (EAγ) in the peripheral blood. Percentages of lymphocytes with receptors for the Fc fragment of IgM (EAγ) did not differ significantly between the atopics and the controls. Serum IgE levels were significantly raised in the patient group and overall serum IgE levels were significantly inversely correlated with percentage EAγ. Although significant (P=0.007), this correlation was not strong (r=0.43) and the relevance of this to atopic disease is discu

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02168.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryIn ragweed‐sensitive and ragweed non‐sensitive subjects the proportions of T lymphocytes bearing receptors for the Fc portion of IgG (Tγ) and IgM (Tμ) were examined as obtained from the blood, and after treatmentin vitrowith ragweed antigen E or concanavalin‐A.The proportion of Tγ and Tμ cells, from the peripheral blood of ragweed‐sensitive and ragweed non‐sensitive persons, untreatedin vitro, were not statistically different. However when T cells from ragweed‐sensitive subjects were exposed to ragweed antigen E, the Tμ subpopulation was significantly increased (P<0.001) without change in the Tγ population. The reverse change occurred when cells of ragweed non‐sensitive subjects were treated with antigen E; there was an increase in the Tγ subpopulation (P= 0.01) but no change in number of the Tμ cells. Cells from both the sensitive and non‐sensitive groups showed increase in number of Tγ and reduced numbers of Tμ cells when incubated with concanavalin A.Since Tγ and Tμ cells appear to have a regulatory function on B lymphocyte differentiation and antibody production, the pattern of responses of Tγ and Tμ subpopulationsin vitroto antigen E in ragweed‐sensitive and ragweed non‐sensitive subjects may reflect a difference in the cellular control of the imm

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02169.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryThe amplified enzyme‐linked immunosorbent assay (a‐ELISA) has been successfully applied to the measurement of allergen‐specific IgE and IgG antibodies. Data presented indicate a high positive correlation among measurements of IgE‐specific antibodies to ragweed antigen E using the a‐ELISA, RAST and radiometric assay of Zeiss. Similarly, a high correlation between allergen‐specific IgG antibodies measured by the a‐ELISA and Farr assay was also observed. Data presented indicate that the measurement of serum IgE antibodies in the linear region of the ELISA titration plot is unaffected by competition with IgG antibodies. The assay is sensitive, reliable, and without risk to laboratory personnel. It is capable of measuring both IgE and IgG antibodies in patients using the same

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02170.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryEighty‐two children with food sensitivity were followed‐up for 2‐5 years. Most children showed a decreasing sensitivity and the clinical course of food allergy seemed to reflect the course of the humoral immune responses to the offending foods. The occurrence of IgE‐ and IgG‐antibodies parallelled in most cases. However, an early, high IgG/IgE food antibody ratio seemed to be a good prognostic sign, indicating a possible blocking capacity of IgG

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02171.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryThe levels of IgE antibodies to inhaled and dietary antigens and total serum IgG, IgA, IgM and IgE were studied in two highly selected populations of children who had either severe asthma and no history of eczema, or severe asthma and generalized eczema. These populations were age‐matched with a healthy control population. The results showed that the eczematous children had significantly higher levels of IgE antibodies to common environmental antigens than the non‐eczematous patients with severe asthma. Both patient groups had significantly higher IgE antigen specific antibody levels than the control population to these antigens. Minor differences in total IgG, IgA and IgM levels were noted between the groups. The variations in total IgE levels between the groups showed the same pattern as for specific IgE antibod

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02172.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryInfants born of allergic mothers but normal fathers, who had eczema and who were fed cows' milk, had a significantly greater incidence of asthma (P<0.001) than infants with a similar history but who were breast‐fed. An analysis of all breast‐fed infants in the study showed that they were less likely to develop asthma than those who were bottle‐fed (P<0.06).There was a lower incidence of allergy in infants born of families with allergic mothers and normal fathers, than in families in which both parents were allergic (P<0.02).In skin tests of both breast or bottle‐fed babies, the two most common allergens eliciting reactions were egg and cat

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02173.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryIn a population of over 200 patients with atopic bronchial disease, significantly increased frequencies of the α1‐antitrypsin Pi‐types of intermediate deficiency (Pi MZ and Pi MS) were found. As far as we are aware of, this report is the first in which strictly objective criteria for patient classification with respect to atopy have been used. A possible biochemical basis for the phenomenon is prese

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02174.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryPatients with ulcerative colitis have been investigated for evidence of defects in secretory immunity. Total serum IgA concentration, serum IgA antibody titres toCandida albicans, salivary IgA and free secretory component concentrations have been measured in thirty‐six patients with ulcerative colitis and thirty‐six normal controls. None of the parameters was significantly different between patients with proctitis and patients with extensive colitis or between the colitis patients and normal contr

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02175.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryAutoantibodies to smooth muscle were found more frequently (21%) in the sera of patients with cystic fibrosis than in age‐ and sex‐matched controls. This appears to be associated with liver involvement. There was no increase in the frequency of occurrence of antibodies to ‘reticulin’ or cell nuclei in the sera of patients with cystic f

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02176.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SummaryWe have investigated the prevalence of atopy within families of cystic fibrosis (CF) patients and compared its frequence in CF patients, their parents and their non‐CF siblings. By studying families with two CF patients it was also possible to evaluate the factors influencing the development of atopy in one CF patient relative to the other patient within the same family. A significant correlation with age (P<0.001) for skin test positivity to common allergens within CF sibling pairs was observed. In 14/18 families studied, only the older CF patient was atopic. The presence of atopy in CF patients was independent of the atopic status of their parent

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1981.tb02177.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY