摘要:

SummaryForty‐eight budgerigar fanciers have been studied and twenty‐five (52%) of these lost their serum budgerigar precipitins after cessation of avian exposure. Twenty (80%) subjects lost their precipitins within 2 years. The lung function was assessed serially in seventeen patients with allergic alveolitis and correlated with the persistence of their serum precipitins. There was no difference in the lung function at presentation or in the incidence of complete recovery between the ten subjects, whose precipitins persisted for longer than 2 years, and the seven individuals in whom the precipitins had disappeared within this time. These observations suggest that budgerigar precipitins do not have a major role to play in the continuing pathogenesis of allergic alveoli

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02588.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryFrom a total of 160 patients with allergic bronchial asthma or chronic asthmatic bronchitis, eighteen (11.3%) patients reported being regularly exposed to pigeons. In these eighteen patients, bronchial provocation tests with pigeon faeces were performed and the precipitating antibodies (IgG) in their serum against pigeon faeces and serum were estimated. Of the eighteen patients, seven (39%) demonstrated a ‘late bronchus‐obstructive response’ to pigeon faeces. Three patients developed only an ‘isolated late response’ and in the other four patients the late response occurred as a part of the ‘dual response’. In the seven patients with the positive late bronchial response, the precipitating antibodies in their serum to pigeon faeces were positive in five (71%) and to pigeon serum in two (28%) of them. The late skin responses to pigeon faeces were positive in five (71%) patients, the blood eosinophilia increased in six (86%) of them, a slight pyrexia occurred in two (28%) and general malaise symptoms appeared in six (86%) of them. None of these patients developed changes on the chest X‐ray during the late response. The remaining eleven patients did not develop any bronchial response to pigeon faeces challenge, although in six (55%) of them the late skin responses were positive, and two (18%) had precipitating antibodies in the serum to pigeon faeces and one (9%) to pigeon serum. It is concluded that positive precipitating antibodies in the serum to pigeon faeces and serum are important parameters for detection of pigeon breeder's disease in exposed individuals, however confirmation of this diagnosis should be provided by the bronchial pr

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02589.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryThe density dependence of maximum flow in ten atopic asthmatics was assessed by response to breathing a helium‐oxygen mixture. They were then subjected to bronchial challenge byDermatophagoides pteronyssinusand density dependence re‐assessed during early and late bronchial reactions. There was considerable individual variation in the density dependence before challenge and in the change in density dependence during induced bronchospasm. However, for any given individual the results were similar during early and late reactions. This suggests that the major site of airflow obstruction may vary from one asthmatic to another but that when antigen challenge is followed by a dual early and late reaction the site of obstruction is similar at each st

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02590.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryLung function and histamine levels in peripheral venous plasma samples were followed after challenge with house dust mite allergen. In eight patients the mean maximal histamine concentration showed a significant rise during the early obstructive reaction when compared with the concentrations at similar time intervals after inhalation of a control solution. In nine other patients treatment with disodium cromoglycate (DSCG) caused a significant fall in plasma histamine concentrations indicating that histamine liberation plays u role during the early obstructive reaction and was released from the lung compartment. Histamine during early obstructive reactions compared with the pre‐inhalation values did show a rise in mean maximal histamine concentration (1.5‐4.1 ng/ml) but this was statistically not significant. During the late reaction neither significant increase in histamine nor inhibition by DSCG was found. Measurement of complement degradation products did not support the role of complement activation during cither early or lute bronchial obstructive reacti

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02591.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryVenom‐specific IgE and IgG antibodies were measured in the sera of bee‐venom‐sensitive patients during a 3‐year hyposensitization period. The level of specific IgG antibodies initially increased, and 2 months after the start of therapy, this increase was on average five‐fold. A concomitant hut non‐significant increase in specific IgE antibodies was also observed initially. Later during the treatment period specific IgE antibodies showed a continuous decline and after 3 years the level was one third of the pre‐treatment level. Venom‐specific IgG antibodies, however, remained above the pre‐treatment level. The disappearance of the severe allergic reactions was related to the level of both IgE and IgG antibodies as demonstrated in seventy‐six bee sting challenges. In patients with specific IgG antibody levels above 400 u/ml, no severe reactions were observed even if the patient had levels of specific IgE‐ antibodies of RAST class 3 or 4. These data suggest that the relationship between venom‐specific IgE and IgG antibodies permits an evaluation of the state of im

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02592.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryIn a group of patients with suspected and probable adverse skin reactions to trimethoprim‐sulphamethoxazole, the lymphocyte transformation test (LTT) was positive in approximately 60% of subjects tested. Levels of stimulation in the majority of cases were low, probably reflecting either use of inappropriate stimulatory forms of the drug or lack of marked reactivity. Since there appeared to be a correlation between peak stimulatory index and duration of the rash, the latter explanation appeared more likel

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02593.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummarySerum dopamineβ‐hydroxylase activity, which is thought to reflect noradrenaline secretion, and free fatty acid level were measured in twenty atopic asthmatic children, of whom ten had exercise‐induced asthma (EIA), after exercise on the treadmill.There was a significant decrease in the level of serum dopamine β‐hydroxylase activity in the asthmatics who developed EIA and this closely accompanied the onset of airflow obstruction. There was no change in the free fatty acid levels. In contrast, the asthmatics, who did not have EIA showed a significant rise in the levels of dopamine β‐hydroxylase activity and free fatty acids after the same exercise task.Our results suggest that the atopic children studied, who developed EIA, may have had an impaired noradrenaline response to exercise. It is further suggested that this impaired noradrenaline secretion may facilitate mediator release and contribute to the airflow obstruct

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02594.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryThe effectiveness of prophylactic treatment with ketotifen was assessed in ten asthmatic patients with aspirin idiosyncrasy in a randomized double blind trial. Increased airways obstruction following challenge with aspirin was significantly reduced when patients were pre‐treated with ketotife

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02595.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryThe therapeutic effects of inhaled disodium cromoglycate (DSCG) and orally administered ketotifen were compared in thirty atopic asthmatics aged 15‐34 years during a 22‐week double‐blind parallel group study. Ketotifen is a cycloheptathio‐phene with experimental antihistaminic, anti‐allergic and anti‐anaphylactic effects equal or superior to those of DSCG. During the first 6 weeks of treatment, mean airflow meter readings increased and bronchodilator use diminished in those receiving DSCG, but no improvement was seen in those given ketotifen. In the next 10 weeks. concomitant therapy was reduced in both groups, but this reduction was greater in the group receiving DSCG. No serious adverse effects occurred. Asthma worsened after abrupt discontinuation of DSCG but not ketotifen. Although a small number of patients may have benefited from ketotifen. its effect on asthma was not comparable with that of inhaled disodium c

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02596.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryIn a retrospective study the mothers of twenty‐one children with well‐defined cow's milk allergy and an equal number of matched controls were asked about their health and diet in pregnancy and the pattern of feeding of their children in infancy. Corroborative evidence was obtained from the medical notes. Nausea in pregnancy was found to be more persistent and atopic disease more common among the mothers of the milk allergic children; in this group food aversions during pregnancy were also more common particularly to dairy produce. The milk‐allergic infants had been breast‐fed for longer and had cow's milk introduced into feeds later than the control group. It is suggested that nausea in pregnancy may be a physiological response to foetal sensitization by dietary antigens such as cow's milk protein, due to impaired placental permeability in atopic pregnant women. A larger prospective study is indicated to substantiate this hyp

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1983.tb02597.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY