ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00173.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00174.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00175.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryWe studied RAST and RAST inhibition tests to black GR, the most frequent sensitizer among several reactive dyes in our previous study, in order to evaluate the specificity of IgE antibodies to hapten or new antigenic determinants and the crossreactivity between two reactive dyes, black GR and orange 3R, in sera from four different sensitized workers. RAST inhibition studies with black GR‐human serum albumin (HSA) conjugate discs demonstrated that black GR‐HSA conjugates were the most effective inhibitors. Orange 3R‐HSA conjugates, unconjugated forms of black GR and orange 3R were weak inhibitors in two patients and non‐inhibitory in one patient, whereas they caused strong dose‐dependent inhibitions in one patient. These results suggested that the IgE response to black GR‐HSA conjugates might be heterogenous and the cross‐reactivity between two reactive dyes differed from one patie

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00176.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryCrossreactivity toDactylis glomerata, Festuca rubra, Phleum pratense, Anthoxanthum odoratum, Secale cereale, Zen mays, andPhragmites communisof IgE antibodies againstLol pI orLol pV was investigated by means of RAST‐inhibition. Within a group of sera the degree of crossreactivity was demonstrated to be highly variable. Individual sera were not always equally crossreactive to all pollen species. A high degree of crossreactivity for Group I allergens did not necessarily implicate the same for Group V. Group I and Group V representatives were found to be present in all eight species. It was demonstrated that within this group of grass species significant quantitative and qualitative differences exist, with respect to Group I and Group V allergens. Species with a low phylogenetic affinity toLolium perenne, likeZea maysandPhragmites communisshowed a very low degree of reactivity, even when measured with the most crossreactive sera. A higher taxonomic relationship however, did not always implicate a closer antigenic resemblance. Antigenically both allergens fromZea maysare more similar toLol pI andLol pV, than the analogues inSecale cereal

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00177.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe acaricidal efficacy of nine marketed products, i.e. Acardust, Acarosan (foam and powder), Actelic 50, Artilin 3A (spirit and water base), liquid nitrogen, Paragerm AK, and Tymasil, and of intensive vacuum‐cleaning have been compared on four different test surfaces: mattress, tufted carpet, gypsum board and rough wooden board, all covered with artificial house dust. They were inoculated with the house dust mite,Dermatophagoides pteronyssinusor the house‐dust fungusAspergillus repensfor evaluation of the fungistatic claims of some products. The acaricidal activity of Tymasil did not surpass that of vacuuming; its fungistatic effect was not apparent. The other products showed complete to almost complete eradication on at least one of the substrates tested. Taking into account the results of acaricidal efficacy as well as the data on safety and practicality acquired earlier, Acarosan powder was considered first choice for carpet treatment. Acarosan and liquid nitrogen, were found to be effective in the treatment of mattress, pillow, upholstered furniture and heavy curtains. On wooden surfaces Acarosan was found to be both effective and safe, while Acardust, Actelic 50, Artilin 3A (both fungistatic as well as acaricidal), liquid nitrogen and Paragerm also passed the efficiency t

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00178.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe outcome of childhood asthma was studied in a cohort of 406 asthmatic children, with emphasis on the influence of family history for allergic disease, as well as the influence of associated allergic diseases on prognosis. Sixty‐two per cent had a positive family history for atopy. In young adulthood no differences, either in symptoms or lung function were demonstrated in comparison to subjects with a negative family history. Fifty‐two per cent of the children had no other allergic disease, 48% had either eczema or hay fever or both. When subjects were stratified based on associated allergic disease, no differences in outcome in adulthood were revealed either. It is concluded that neither a positive family history, nor concurrent associated allergic diseases in the child contribute to the prognosis of asthma from childhood to young adulthood. Therefore, environmental factors as well as patient characteristics (including lung function level, level of bronchial responsiveness) are likely to be more important for the progno

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00179.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryIn a comparative study six different protein hydrolysates, marketed as ‘hypoallergenic’ infant formulae were investigated by skin prick tests, RAST, RAST inhibition and titrated provocation tests. Whey hydrolysates containing a high percentage of larger peptides were found to have the highest capacity to induce positive skin tests, provocation tests and. To bind to human serum IgE antibodies of cow's milk allergic children. Casein hydrolysates appeared to have the least residual allergenic activity. We recommend that ‘hypoallergenic’ formulae should be tested in each case, before being prescribed to cow's milk sensitive c

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00180.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00181.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe effect of single dose topical nasal therapy with azelastine hydrochloride (azelastine) on the response of nasal airways resistance (NAR) to provocation testing was studied in 36 patients with seasonal allergic rhinitis. Nasal provocation testing (NPT) with histamine or grass pollen was performed after a single dose of azelastine, 0.28 mg to each nostril, or placebo. NAR was assessed by rhinomanometry for 10 hr following NPT. Compared to placebo the NAR response to histamine was inhibited at both 1 and 2 hr following azelastine administration, significant at 1 hr (P<0.02) and 2 hr (P<0.0001). No such effect was observed in relation to allergen‐induced changes in NAR. Azelastine also inhibited numbers of sneezes for up to 10 hr following both histamine NPT (P<0.02) and allergen NPT (P<0.05), when compared to placebo. Forty‐seven per cent of participants experienced bitter or unpleasant taste sensations after azelastine administration but no other unwanted effects were clearly related to azelastine ther

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1992.tb00182.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY