摘要:

The effect of various immunosuppressive agents on the experimental mice amyloidosis has been examined. The mice were pretreated with 21 injections casein, on day 1, 3 and 5 after this treatment 12 immunosuppressive agents were applied to 12 groups of mice in dosis corresponding to LD10. All drugs applied accelerated the amyloidosis, even they differ in metabolic blocking potencies. The results seem to indicate that any interference with the immune apparatus of the mice favours the development of amyloidosis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00515.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Twenty cases of progressive respiratory distress (PRD) in adult patients following shock in connection with trauma, post‐operative complications or serious acute diseases are reviewed. The development of pulmonary consolidation with the formation of hyaline membranes (HM) in these cases is described in detail. Organization of the HMs may result in fibrous obliteration of respiratory bronchioles and alveolar ducts, if survival is sufficiently long. This is a highly characteristic picture. Thin HMs without organization, interpreted as early lesions, were found among twelve additional cases treated by artificial ventilation; these patients did not develop PRD but died of other causes. The relation of the pathological findings to certain clinical factors, such as length of survival with PRD, duration of mechanical ventilation and oxygen concentration, has been investigated. The results seem to concur with the theory that the pulmonary lesions are precipitated by inadequate tissue perfusion and possibly also intravascular coagulation during shock, leading to endothelial damage and reduced alveolar surfactant. Probably there are many important contributary factors, such as the mechanical effects of artificial ventilation, high oxygen concentration, infection, etc. “The respiratory distress lung” seems to be an appropriate morphological term for this type of lung lesion, which may also be precipitated by uraemia and viral pneumonia, for example, and greatly resembles the hyaline membrane disease in the ne

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00516.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

At autopsy,Actinomycescolonies were found in the tonsils in 9 out of 22 bodies under the age of 35 years. This seems to indicate that tonsillar crypts is a normal habitat of such colonies.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00517.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00518.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY