摘要:

During dipyridamole treatment of rats cellular proliferation is observed in the myocardium and skeletal muscle. The proliferative activity in the myocardium is exclusively localized to capillary walls. The localization within the skeletal muscle has not been analysed.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02015.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The present study showed that the pancreas of two monkey species contained sulphated blood‐group substance. Such strongly anionic molecules are known to bind calcium, and their solutions form gels in the presence of cations. It is suggested that such a mechanism may be involved in cystic fibrosi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02016.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The first described case of a highly differentiated gastric adenocarcinoma, with light microscopic and ultrastructural features, pointing to the normal gastric epithelium as the site of origin, is presented.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02017.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

After injection of a mixture of carbon black and a iodinated X‐ray contrast medium into the cerebral ventricles of rats carbon black loaded macrophages were found in the alveolar septa in the lungs. It is concluded that contrast media used in cerebral ventriculography are eliminated at least partly by discharge of pulmonary macrophage

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02018.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

2000 consecutive liver needle biopsies were examined for the occurrence of biliary hamartomas (von Meyenburg complexes, microhamartomas). In 12 biopsies (corresponding to 0.6 per cent) a total of 15 hamartomas were found as 2 biopsies contained 2 and 3 hamartomas, respectively. The incidence, morphology, location and differential diagnosis are discussed. In serial sections a communication between all the lumina in each hamartoma was found. In no case the diagnosis of biliary adenoma, congenital hepatic fibrosis or polycystic liver could be made. The hamartomas are of no clinical importance.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02019.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The surface structure of a series of malignant neurogenic rat cell lines in culture has been investigated by scanning electron microscopy. Neoplastic transformation was induced by a single transplacental administration of the carcinogen ethylnitrosourea (ENU) to BD‐IX rats on the 18th day of gestation. The malignant cell lines were established either by explantation into culture of cells from solid gliomas or neurinomas developed in the offspring, or by transfer of fetal brain cells to culture where they subsequently underwent malignant transformation. A high degree of surface activity was observed, as evidenced by microvilli, filopodia, ruffling membranes and zeiotic blebs. Surface activity was highest in cell cultures giving rise to glioma‐like tumours upon re‐implantation into syngeneic hosts, and low in those giving rise to neurinoma‐like tumours, with one exception. The lowest surface activity was seen in a cell line which was not tumourigenic. High surface activity was mostly correlated with a high degree of aneuploidy. No correlation was apparent with other properties of the neoplastic cell lines, e.g., stem line ploidy and population doubling time in cell

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02020.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The incorporation of H3‐ leucine into protein from anterior and posterior cerebellum, cerebral cortex and liver was studied in rats given 50% of calories as ethanol, brandy, whisky, gin, red wine or isocaloric amounts of glucose together with diets with moderate or low protein‐vitamin content for 8–9 months. Higher incorporation rates were usually observed with higher protein‐vitamin administration. Red wine and brandy rats usually had the highest, ethanol and gin rats usually the lowest incorporation rates. The incorporation rate thus increased with amount of congeners

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02021.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The neoformation of myocardial blood capillaries was investigated on cardiac autoradiograms from3H‐thymidine injected rats that had been swimming‐exercised for two weeks, rats that had been resting for three months following the exercise, and rats in which the rest had been followed by a second two‐weeks period of exercise. The initial period of exercise induced a significant capillary neoformation in the hearts. The newly‐formed vasculature was found of functional significance still at the end of the resting period and available for the increased demands on the myocardial vasculature when the exercise was

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02022.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Tissue‐sections from 12 methylcholanthrene‐induced carcinomas of the cervix uteri of mice were tested for the presence of an antigen normally confined to the cervicovaginal epithelium. The antigen was detected in 10 of the 12 tumours investigated with indirect immunofluorescence, and in all 7 tumours studied with the more sensitive method of mixed hemagglutination. The concentration of the antigen was generally higher in the well‐differentiated areas of the tumours, but it was also found associated with solitary tumour cells, apparently invading the stroma. The presence of CVA in the tumours suggests an origin of the tumour cells from the cervicovaginal epithelium. The cyclic AMP dependent protein kinase (EC 2. 7. 1. 37) in the tumour cytosols was studied by chromatography on agarose and DEAE‐cellulose. The enzyme showed the same properties as that from normal vaginal epithelium. The tumour cells thus contain an apparently normal complement of this enzyme, which is believed to be responsible for most of the intracellular actions of cyc

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02023.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Primary amino groups may be selectively labelled in living cell cytoplasmic components by staining with the covalently binding fluorochrome reagent fluorescamine. The reaction is extremely rapid and occurs at very low reagent concentrations. Cells survive such treatment and gradually remove or metabolize the labelled substances. Nuclei and nucleoli are not labelled, while lamellar cytoplasm, which contains little actual cytoplasm, is well demarcated, thus indicating that the method is useful for studies of cell membrane components. Labelled cell membranes can be prepared for further purification after preliminary external fixation of cell membranes with a supravital polyaldehyde fixative. The use of dimethylsulfoxide as a solvent for fluorescamine allows much longer survival of the cells than the use of acetone as a solvent. In addition, the use of high pH and borate buffer was not necessary to the labelling phenomenon.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1978.tb02024.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY