摘要:

A series of 24,388 consecutive autopsies yielded 148 cases of amyloidosis, for which the associated diseases were tabulated. 13 solid primary malignacies were found in eleven patients, including one mucoepidermoid cancer of the parotid and one thymoma; two out of eleven had evidence of pyelonephritis. Five patients suffered from past or present renal adenocarcinoma, the most common carcinomatous cause of amyloidosis. Systemic amyloid deposits thus occurred in 2.1% of autopsied patients with renal carcinoma, but showed no obvious correlation with tumor stage or histologic type. Details are presented of an unusual case of hypernephroma producing a stable bronchial metastasis cuffed by nodular amyloid and dissociated by a lymphoid infiltrate containing plasma cells. The occurrence of systemic amyloidosis in non‐hematologic malignancy thus appears to be a rare event, which, especially in the case of renal cancer, is assumed to be due to amyloid‐fibril protein

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00239.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Morphological, serological, DNA‐homology and immunofluorescence studies of a rapidly fatal malignant lymphoma in a 25‐year‐old Swedish male revealed most of the characteristics of an EBV‐associated Burkitt lymphoma. The various findings are discussed in relation to previously reported observations on endemic (African) and non‐endemic Burkitt

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00240.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Parathyroid morphology was studied in 45 irradiated and 37 control rats. The irradiated rats received a single parathyroid dose of about 6.5 gray. The rats were killed and autopsied 14 months later. The radiation resulted in fibrosis and depression in weight of the parathyroids. In irradiated rats eleven parathyroid adenomas and four thyroid tumors were found. In control rats no tumor occurred in either parathyroid or thyroid glands. All irradiated rats, including those with a parathyroid adenoma, were normocalcemic.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00241.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Eighty‐one children aged 4–18 months with unsatisfactory weight gain were investigated for organic diseases; the investigation included small‐intestinal biopsy. Sixteen had total villous atrophy, in most cases due to gluten intolerance. Transient disease, e.g. cow's milk protein intolerance, was probable in 7 children with subtotal atrophy. In 18 children the only abnormal finding was an increased number of inflammatory cells in the mucosa, a finding which was probably of no clinical significance. Planimetric measurement showed good agreement between the mucosal surface/volume ratio and an ordinary histological grouping of the mucosa. A significant correlation was found between the rate of weight gain during the period preceding investigation and mucosal surface/volume

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00242.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The histological distribution of receptors for the lectins Wheat germ (WGA), Ricinus communis I (RCA I) and Soybean (SBA) was examined in ameloblastomas and normal oral mucosa from 12 patients. The study utilized fluorescein‐conjugated WGA, RCA I and SBA. Cell‐membrane bound receptors for these 3 lectins were demonstrated in the spinous cell layer of the normal oral mucosa. WGA and RCA I receptors were also located in the basal cell layer, whereas SBA receptors were not detectable there. Cell‐membrane bound WGA receptors were shown in the epithelial cells of the ameloblastomas. Titrations showed significant differences in staining reactivity related to the morphology of the peripheral epithelial cells of the ameloblastomas. The distribution of RCA I and SBA receptors in the peripheral cells was also related to the morphology of these cells and was independent of the histological types of the tumours. It is suggested that the distribution of these receptors is related to cellular activities such as cell differentiation and cell migration in the tumour and therefore possibly reflects the biological behaviour of the tu

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00243.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Skin biopsies from a patient with epidermolysis bullosa acquisita (EBA) were studied ultrastructurally and by immuno‐electron microscopy. The specimens were taken from non‐predilection areas as well as of the skin predilection areas of the patient.In vivodeposits of IgG were found below the lamina densa associated with the anchoring fibrils in all areas of the skin. The bullae and the artificial friction blisters appeared in the same position on the dermal side of lamina densa. The results suggest that epidermolysis bullosa acquisita is a distinct nosologic entity. The close resemblance of epidermolysis bullosa acquisita to cicatricial pemphigoid in immunofluorescence studies makes the use of immuno‐electron microscopy important in the classification of these dis

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00244.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Autopsy findings in a 55‐year‐old man known to have been occupationally heavily exposed to titanium dioxide dust showed extensive pulmonary deposition of white pigment. By energy dispersive X‐ray analysis (EDAX) and electron and X‐ray diffraction, the pigment was identified as rutile. By ordinary transmitted light microscopy, deposits of the white crystalline titanium‐dioxide could not be distinguished from anthracotic pigment present in the lung sections. By transmitted polarized and incident light microscopy, the different nature of the two types of pigment was immediately evident. Absence of inflammatory and fibrotic changes in the lungs in our case lends support to the view that rutile is biochemica

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00245.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A ten‐year consecutive material of 306 minor surgical specimens from the anal canal showed squamous dysplasia in 2.3 per cent. None of the patients developed carcinoma during an average observation time of 27 months. The average age was 64 years for dysplasia and 67 years for a corresponding series of 12 cases of anal canal carcinoma. It is concluded that all material from the anal canal should be investigated histologicall

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00246.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY