摘要:

Eight pigs and six pregnant sows were infected with cysts of a porcine strain or trophozoites of the RH strain ofToxoplasma gondii.The pigs and the sows with their offspring of retained, stillborn or liveborn piglets, were examined for pathological changes at death, parturition or sacrifice. The pathological changes did not appear to be influenced by the infecting strain, but the extent of the lesions was more pronounced in the younger than in the older animals. The lesions in acute fatal infections of retained or stillborn piglets, in liveborn congenitally infected piglets, and in one pig and one sow were characterized by changes of exudative and degenerative nature with focal necrosis.Toxoplasmawas demonstrable morphologically in all animals that died after clinical disease, and non‐viableToxoplasmawas demonstrable in 17 of 24 retained or stillborn piglets with pathological changes. The lesions in chronic infections of piglets, pigs and sows were characterized by reactive changes with formation of granulomas. Morphological demonstration ofToxoplasmawas difficult in these cases, even though pathological changes indicative of toxoplasmosis were present. It is suggested that, in certain circumstances,Toxoplasmais able to provoke a tissue reaction of “specific” granulomatous n

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03299.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The association between bacterial infection and placentitis and between various non‐infectious complications of pregnancy and of delivery and placentitis were investigated by means of a combined morphological, bacteriological, clinical and statistical study, including multiple regression analysis. 134 placentas from 132 mothers with the various complications were included in the series. It could not be proved that bacterial infection is the main cause of placentitis, nor even a major cause. On the other hand, some non‐infectious complications in particular meconium staining of the amniotic fluid, prolonged labour, and premature rupture of membranes, seem to be more important causes. Foetal acidosis as a possible inductive factor in placentitis is sugges

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03300.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A 59‐year‐old man with co‐existing carcinoid syndrome and hyperinsulinism is described. The clinical examination revealed multiple tumour foci in an enlarged liver, and a subtotal hepatectomy (800 g) was performed. No primary tumour was revealed. The tumour had a light microscopical picture agreeing with a carcinoid or an insuloma; cytochemically and ultrastructurally most of the tumour cells presented characteristics of an intestinal carcinoid. The evidence of a presence of insulin producing β‐cells in the tumour was rather vague. Biochemically, the tumour tissue showed only a faint insulin‐like activity and a low content of radio‐immunologically measurable insulin. Since the total tumour mass was large, it could, however, not be excluded that production of insulin by some tumour cells may have caused the hyperinsulinism. The possibility of insulin‐releasing substances produced by the tumour cells was also considered possible. A co‐existing islet β‐cell tumour was improbable since both the carcinoid syndrome and the hyperinsulinism disappea

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03301.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

In connection with a survey of previously published reports, three cases of primary linitis plastica of the colon and rectum are presented. The clinical symptoms appear late, and the predominant complaints are abdominal pains, changes in bowel habits and the appearance of blood in the stools. Roentgenologic examination of the colon shows a segmentally constricted lesion and in the cases where proctoscopy is carried out, the findings are often atypical. Since the histologic pattern is identical in primary and secondary linitis plastica of the colon and rectum, primary tumours in other regions, first and foremost in the stomach and, in exceptional cases, in the gall bladder, must be excluded. The treatment consists of very wide resection, accompained by hystero‐salpingooophorectomy. Cytostatic therapy may be attempted. After surgery the patients usually survive for periods ranging from a few months to two years, the average length of survival being five month

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03302.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Massive doses of vitamin‐D in a few days provoke heavy clinical symptoms and histologically significant vascular changes, particularly in the aorta, coronary arteries and renal vessels of rats. Intravenous administration of zymosan completely cuts out these effects. Our conclusion is, therefore, that inactivation of circulating complement inhibits the vitamin‐D produced arterial lesions. We suggest that complement not only is an important factor in arteriosclerosis produced by vitamin‐D poisoning, but find it conceivable that it may play a similar key role in human aortic and coronary scle

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03303.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The cyclic variations in the rat mammary gland seem to be of no significance for the induction of breast cancer by dimethylbenzanthracene (DMBA) nor for the development of hormone sensitivity in these tumours. The uptake studies give no indication of any competition between oestradiol and DMBA with regard to intracellular binding. The occasional occurrence of one hormone‐sensitive and one hormone‐resistant cancer in the same animal points to the significance of local factors for the development of hormone‐sensitivity in breast ca

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03304.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The frequency of sex‐chromatin‐positive cells and the number of nucleoli/cell were studied in relation to growth phase in cultures of skin fibroblasts from normal human males and females, one 46‐XX male, four 47‐XXY males and three 48‐XXXY males. The main conclusions are: 1) The frequency of sex‐chromatin‐positive cells is low in the logarithmic growth phase, but rises very close to 100 per cent in the postlogarithmic phase in normal females as well as in sex‐chromatin‐positive males. 2) In three 48‐XXXY males investigated the frequency of cells with two Barr bodies showed minima of 22, 20 and 22 per cent in the logarithmic phase and maxima of 90.5, 75.5 and 71.5 per cent in the postlogarithmic phase. 3) The location of the Barr body changes during growth with a significant rise in the relative frequency of Barr bodies non‐adjacent to the nuclear membrane (i.e. juxtanucleolar and intermediary Barr bodies) from logarithmic to postlogarithmic phase. 4) The average number of nucleoli per cell is significantly higher in normal females than in normal males and significantly higher in the three 48‐XXXY males than in the normal female controls. 5) The average number of nucleoli per cell increases significantly during the logarithmic growth phase reaching a maximum at day 5, 6 or 7. 6) There is no difference between the average number of nucleoli in Barr‐positive and Barr‐negative cells. It is suggested that the explanation of fact No. 4 is that the heterochromatic X‐chromosome is nucleolus‐organizing and has a stronger nucleolus‐organizing action than the Y‐chromosome, and that facts Nos. 3 and 5 may be a consequence of an alteration in the distribution of the cells in the different intermito

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03305.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Mice injected intraperitoneally with Ehrlich ascites carcinoma were killed after varying intervals 2 to 21 days after injection. Tissue specimens from the kidney, spleen and heart were examined histochemically for mono‐amines in the adrenergic fibres and the noradrenaline content of the kidney was chemically determined. The mono‐amine‐indicating fluorescense was subjectively estimated as absent or faint in a greater number of slides, and correspondingly as clear in a smaller number of slides in the ascitic group than in the controls, the difference being highly significant. This applied to the adrenergic fibres of the blood vessels of the kidney, to the arterioles of the spleen and to the adrenergic fibres of the myocardium. A highly significant reduction in the chemically determined content of noradrenaline was found in the kidney of ascitic mice as compared with the con

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03306.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Eighteen clinically benign and eleven clinically malignant human brain tumours, subdivided into four groups with five fibromatous meningiomas, seven meningotheliomatous meningiomas, six neurinomas and nine gliomas (gr. II–IV) were grown in three‐dimensional matrix cultures in fresh autologous serum. The growth and maintenance of the primary explants were measured microscopically in serial sections and by autorodiography of tritiated thymidine uptake. There was a good correlation between these two parameters, but no statistically significant difference between clinically benign and malignant tumours with respect to their growth potential in the matrix could be demonstrated. The group of clinically benign fibromatous meningiomas had a significantly higher growth potential than the other tumour groups. The morphological differentiation was well maintained in the actual explants and in many cases the outgrowing cells reproduced the original morphology within the lacunae of the mat

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03307.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Changes that were interpreted to be of regenerative nature were studied in Chinese hamsters treated with ethionine or excess methionine. Numerous ductules and associated nodules of rather large cells were seen in the light microscope. Ultrastructurally, the endoplasmic reticulum of unaffected and damaged acinar cells showed a whorled appearance. Exocrine cells with no or few zymogen granules and low or moderate cytoplasmic electron density were found. There were other exocrine cells that exhibited prominent endoplasmic reticulum consisting of vacuoles, vesicles, and cisternae, the latter containing electron dense masses. Occasional mitoses were seen in acinar and ductule cells. The endocrine pancreas showed some new formation of cells, with the occurence of granulated cells in ductules. It is suggested that, in pancreas damaged by the administration of ethionine or excess methionine; there is regeneration of acinar parenchyma by mitotic cell division, by restitution of damaged cells, as well as by new formation of cells from ductules. In addition, there is some new formation of endocrine cells.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb03308.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY