摘要:

The activities of alkaline and acid phosphatases and of dehydrogenases (NADH, LDH, SDH, α‐glyc. and G‐6‐DH) have been studied in a material of endometrial biopsy specimens taken about six days after the ovulation from 23 women with undesired childlessness. The results are in fair agreement with those of previous examinations of the endometrium, except regarding the activity of G‐6‐DH, which varied considerably. In six women with no detectable cause of sterility no activity of G‐6‐DH could be demonstrated. The possibility of a causative relation between blocking of the pentose shunt and sterilit

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01826.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

80 specimens of mammary tissue presenting benign and malignant changes were subjected to biopsy with a view to disclosing activity of unspecific a'lkaline phosphatases. The material comprised 40 carcinomas, 32 cases of fibroadenomatosis, 7 fibroadenomas, and 1 carcinomain situ.In the cases of carcinoma no or only slight phosphatase activity was found in the tumour cells. The surrounding stroma often showed “reaction zones” formed by proliferating fibroblasts with high phosphatase activity. This stromal response was found in 65 per cent of the biopsy specimens of carcinoma, while another 7.5 per cent were doubtfully positive. The incidence of reaction zones was seen to increase appreciably with rising grades of tumour anaplasia. (Grade I 33.3 per cent, grade II 65 per cent, and grade III 90.9 per cent). Further, correlation was found between reaction zones and stromal lymphocyte infiltrates. The pathogenesis of the reaction zones is discussed, and the conclusion has been drawn that a stromal reaction against the tumour must be the most likely hypothesis. In fibroadenomatosis 18.8 per cent of the biopsies revealed reaction zones. The question has been considered whether the observation might be employed for a delimitation of a high risk group of patients with fibroadenomato

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01827.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The slides from 35 cases of lymph node biopsies with the initial diagnosis of Giant Follicular Lymphoma or Giant Follicular Hyperplasia were re‐examined according to selected histo‐pathological criteria. The same slides were also sent for diagnosis to eight different trained pathologists without any information on previous diagnosis or clinical picture. The 35 patients were clinically followed up and their fates registered. There were some (2 of 19 cases) false positive diagnoses, and some (2 of 16 cases) false negative diagnoses. Differences of opinion between the pathologists were registe

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01828.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Inflammation was induced in the abdominal skin and musculature of mice by subcutaneous injection of turpentine. The leakage of serum proteins estimated by the trypan blue technique was found to be diphasic, both in the skin and musculature. The early phase was completed in about 2 hours. The late phase started at about 3 hours and reached a maximum 12 to 16 hours after turpentine injection. However, even at 48 hours considerable dye leakage was present. By means of the colloidal carbon technique, turpentine was found to induce a diphasic labelling of venules in the, skin and musculature, the early phase being slight and short‐lived, the second marked and prolonged. Labelling of capillaries occurred in the panniculus carnosus in the first half hour of inflammation. At 36 and 48 hours capillary labelling occurred in a ringshaped area of the skin. In the musculature capillary labelling occurred in the first 3 hours of inflammation. Tissue necrosis was present in the panniculus carnosus at 14 hours, in the dermis at 24 hours and in the epidermis at 48 hours of inflammation. Necrosis was also present in a thin layer of the musculature close to the abscess wall after 14 hours of inflammation. Inflammatory oedema developed rapidly during the second hour of inflammation and slowly during the following 22 hours. Some relations between protein leakage, vascular carbon labelling, tissue necrosis and oedema formation are discusse

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01829.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Ejaculates from 200 men were examined by the sulphide silver method for the demonstration of metals and by cytochemical methods for the demonstration of lactate and succinic dehydrogenase, NADH‐diaphorase, acid and alkaline phosphatase and nonspecific esterase. By the sulphide silver method, a band‐shaped pattern of silver precipitates (sulphide silver pattern, SSP) appeared in the middle piece of the spermatozoa. 5–9 transverse or oblique bands was regarded as normal. Spermatozoa classified as normally outlined as well as spermatozoa classified as abnormally outlined sometimes showed irregularities in the SSP of the middle piece. The sulphide silver method thus provides a possibility for a further differentiation of spermatozoa. Also by cytochemical methods for the demonstration of lactate and succinic dehydrogenase and NADH‐diaphorase, a band‐shaped pattern appeared in the middle piece, though somewhat less distinct than the SSP. A statistically significant correlation between the percentage of spermatozoa with a regular SSP of the middle piece and the percentage of motile spermatozoa

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01830.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Human testis and epididymis obtained at autopsy after sudden death were studied by the sulphide silver method for the demonstration of metals and by histochemical methods for the demonstration of succinic and lactate dehydrogenase, NADH‐diaphorase, acid and alkaline phosphatase and nonspecific esterase. By the sulphide silver method and methods for demonstrating succinic and lactate dehydrogenase and NADH‐diaphorase, a band‐shaped pattern appeared in the middle piece of spermatozoa from testis and epididymis of the same appearance as that previously found in spermatozoa from ejaculates. Irregularities of the band‐shaped pattern of the middle piece were found already in the

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01831.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A tissue culture technique for the study of the mixed leucocyte reaction (MLR) occurring between allogeneic chicken spleen cells was developed. Some features of the one‐way MLR, using mitomycin C‐treated spleen cells as stimulators, and the two‐way MLR were characterized. Cells forming antibody to histocompatibility or other antigens common to lymphoid cells and erythrocytes could not be detected in the MLR. Spleen cells from hypogamma‐globulinaemic bursectomized‐irradiated chickens reacted normally both in the two‐way and one‐way MLR. It is suggested that the MLR occurs between thymus‐dependent lymphoid cells or between such cells and macrophages. Bursa‐dependent lymphoid cells appear to play a non‐essential role,

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01832.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A surgical method for accessory cervical heart transplantation in rabbits and rats has been developed and the procedure is described in detail. For blood vessel anastomosis the method employs an extra‐luminal teflon prosthesis. This non suture technique is found to be easy, quick and reliable in the hands of an operator without experience in microsurgery. The most frequent postoperative complication is thrombosis of the carotid artery occuring in 30 per cent of the rabbit recipients and 10–15 per cent of the rats. The superficial cervical localization of the transplant is found to be advantageous for control with function of the heart, and for exact determination of endpoint of the rejection proc

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01833.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The morphological changes have been studied in 35 ectopically allotransplanted rabbit hearts. The grafts survived rejection for an average of 9.9 days in unmodified recipients and permitted serial biopsies beeing taken. Generalized mononuclear cell infiltration of the myocardium, interstitial oedema, endothelial oedema and proliferation and generalized myo‐cardial damage were the most prominent histological changes at rejection. A very small number of the infiltrating cells contained cytoplasmatic 7‐globulins. 7‐globulins were traced to the sarcolemma and heavy deposits could be seen intracellularly in degenerating myo‐cardial cells. Electrocardiograms showed that decline in voltage was the most reliable indication of impending cardiac re

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01834.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Based on review of the literature and ten cases of our own it is concluded that the specific adrenal lesion in patients with idiopathic Addison's disease is a diffuse lymphocytic adrena‐litis. It is proposed to substitute for the term idiopathic Addison's disease the nameAddison's adrenalitis, since the disease has clinical, immunological and patho‐anatomical features of its own. Adrenal glands from two autopsy series of 413 and 161 cases were investigated for the occurrence of focal lymphocytic adrenalitis. Small numbers of lymphocytes were found in 15 per cent and 18.6 per cent, respectively. Lymphocytic infiltrates which to some extent resembled the infiltrates in focal thyroiditis were found in only 2.4 per cent and 1.8 per cent in the two series. These infiltrates were also very small and the existence of a significant focal lymphocytic adrenalitis seems questiona

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01835.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY