摘要:

Methylthiouracil (4‐Methyl‐2‐thiouracil: MTU) had a strong goitrogenic effect in C3H mice. Metabolic studies showed a significantly higher consumption of oxygen in thyroid gland tissue after treatment with MTU. Malignant changes were not observed. The serum of MTU and Thycapzol treated mice showed a higher capacity to bind T3—indicating a lower production of endoge

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01856.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Postmortem examination of a woman with epidermoid carcinoma of the cervix uteri revealed numerous tumour emboli in small pulmonary arteries. Some arteries were occluded by tumour cells showing extensive necrosis in the central part of the lumen. In many arteries groups of tumour cells were present along the vessel wall while the central area was occupied by a partially organized thrombus or connective tissue. The tumour cells looked viable near the vessel wall and close to the intravascular connective tissue, while necrotic cells were often found in the centre of the groups of tumour cells. The intravascular tumour growth was poor in arteries with extensive perivascular tumour growth. The tumour grew better in perivascular lymphatics than in the arteries. It was concluded that the observations made in this case supported the hypothesis that necrosis of tumour cells in pulmonary tumour emboli was due, in part at least, to nutritional insufficiency caused by circulatory disturbances produced by the tumour itself.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01857.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Half an hour, 4, 8, 16, 24 hours and 6 days after the injection of chicken red blood cells (CRBC) into the hind foot pads of germfree mice their popliteal lymph nodes were studied in one‐micron sections and in the electron microscope. The untreated germfree lymph node was characterized by the absence of a sinus system and a poor cellularity. Mast cell degeneration, dilatation of small blood vessels, infiltration of the peripheral lymph node parenchyma with polymorphonuclear cells and formation and widening of a sub‐capsulary sinus space were early signs of antigenic stimulation. Later, dilatation of high endothelial venules filled up with leucocytes, lymphocyte infiltration and lymphocyte degeneration were prominent features of the induction phase. Six days after stimulation germinal centre activity had develo

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01858.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Renal biopsy specimens from four adult patients with the Schönlein‐Henoch syndrome and complicating renal disease were examined by light and electron microscopy. By light microscopy three patients showed diffuse hypercellularity of intercapillary cells and hyper‐plasia of intercapillary cell matrix in almost all glomeruli. From twenty to fifty‐five per cent of all corpuscles from these patients had epithelial crescents in Bowman's capsule. In one patient with focal and segmental proliferative changes, but without crescents, focal and segmental thrombosis and necrosis were found. Three patients had moderate to severe glomerular infiltration with Polymorphonuclear leucocytes. Electron microscopy confirmed the proliferation of intercapillary cells and hyperplasia of intercapillary cell matrix. Hypercellularity of visceral epithelial cells and endothelial cells were not found. In the epithelial crescents of Bowman's capsule two cell types could be recognized: dark cells and light cells. In between these cells basement membrane‐like material was demonstrated. Electron dense deposits were seen in the subendothelial space of the basement membrane, and in the cytoplasm of endothelial cells. To a lesser degree, similar deposits were found in the intercapillary region, in the subepithelial space, and in visceral epithelial cells. No “humps” w

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01859.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Rats, inoculated when newborn with Rous sarcoma virus (SR‐RSV), were inoculated with irradiated syngeneic Rous tumour cells or with syngeneic lymphoid cells from specifically immunized donors. Treatment with irradiated tumour cells gave no demonstrable protection, while administration of specific immune lymphoid cells before and in some experiments a few days after SR‐RSV inoculation had a protective effect. Together with the fact that both tumour‐negative and tumour‐positive rats show a high degree of cell‐mediated and humoral immunity the results indicate that the rapidity with which the cell‐mediated immunity develops plays an important role for the progressive growth or elimination of the neopl

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01860.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Kidney biopsies from five patients with ankylosing spondylitis were studied electronmicro‐scopically. In four patients renal arteriolar changes were observed. The structure and distribution of the lesions corresponded to the descriptions of renal arteriolar hyalinosis occurring in other conditions. There was nothing to suggest that the deposits originated from the cells, the elastic tissue or the basement membrane of the arteriolar wall. Their origin appears likely to be haematogenous. Immunological events are possibly involved in producing the vascular lesio

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01861.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Primary heart tumours are extremely rare and have apparently never been reported in Sweden. At autopsy, we have had the opportunity of seeing a sarcoma of the heart with certain features of angiosarcoma. In this case the clinical symptoms had been blurred by a coexisting heart defect and thereby precluded demonstration of any relation between the cardiac symptoms and the tumour. Neither were laboratory data helpful in assessing the age of the tumour.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01862.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

In rat kidneys the earlypost mortemchanges of the cortical tubules and of the peritubular capillaries were investigated after different forms of preparation. In theinstantly frozen, freeze‐driedtissue, a systematic, correlated orientation of the tubules in the renal cortex was found. The main axis of the tubules was orientated radially out to the surface of the kidney, and the corresponding peritubular capillaries were orientated parallel to the tubules. The total interstitial volume in the kidney cortex was found quantitatively significant (21 per cent), including the capillary volume (7 per cent). This was compared to theconventional fixed tissue, in which the total interstitial volume was 9 per cent, and in which the capillaries were not readily recognized.In instantly frozen, freeze‐substituted tissueslight artificial changes were found, but the parallel orientation of the tubules and the capillaries could still be recognized.In freeze‐substituted tissue, frozen 2 minutes after the removal of the kidney and in conventionally fixed tissue, the parallel, radial orientation of the tubules and capillaries was dist

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01863.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The aim of the present study has been to correlate the degree of malignancy of tumours involving the cervix uteri, expressed by a 5‐year survival rate, with histological morphology, nuclear size, and content of DNA. The series comprised 117 patients. DNA‐coritents were determined histochemically by U‐V‐absorption, the nuclear sizes being determined by planimetric measurements. The clinical stages and 5‐year survival rates were found to be correlated and furthermore, malignant tissue from patients with cervical tumours was found to present increased contents of DNA in nuclei of the tumour cells as well as significantly enlarged cellular nuclei. A correlation between histological morphology and degrees of malignancy was not observed and our study fails to provide a basis on which to confirm the findings obtained by other authors, for instance, that prognostic data might be obtainable on the basis of the relative DNA‐content and/or nuclear sizes in malig

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01864.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Unilateral radiation nephritis was induced in 20 rats. This regularly resulted in the development of hypertension, but only after removal of the non‐irradiated kidney. The increase in blood pressure was unrelated to uraemia. The irradiated kidneys showed typical micro‐angiographic alterations consisting in a reduction of the cortical vasculature, whereas the medullary vasculature was well visualized. These alterations were ascribed to glomerular lesions induced by the irradiation. Renal arteriolosclerosis was mild or absent. The juxtaglomerular cell granulation was increased in the non‐irradiated kidney early after irradiation, and tended to return to normal levels by prolongation of the interval from irradiation to removal of the non‐irradiated kidney. It is suggested that: (i) the non‐irradiated kidney exerts a protective action on the blood pressure level in unilateral radiation nephritis, (ii) the development of hypertension after removal of the non‐irradiated kidney is due to an altered vascular pattern in the irradiated kidney resulting in a relative cortical ischaemia, and (iii) the radiation causes an acute damage of the juxtaglomerular cells, which, in the present experiments, was

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb01865.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY