摘要:

The occurrence of amyloidosis in obese‐hyperglycemic mice (genotypeobob) about 18 months old and their lean litter‐mates was studied. Amyloidosis of varying degrees was found in 60 per cent of the mice and was equally common in both groups. Large amounts of amyloid were usually seen in the adrenal glands, liver, spleen and kidneys. In the kidneys, the amyloid was found mainly in the glomeruli, in the mesangial region. Electron microscopy of isolated amyloid fibrils showed that these consisted of two filaments about 40 Å thick, twisted around each other. It is concluded that the distribution of the amyloidosis in these mice is similar to that seen in secondary or experimental murine amyloid

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03891.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Forty‐two patients with a bladder tumour and 4 patients with a ureteral tumour and a history of abuse of phenacetin‐containing analgesics were studied. The sex ratio was 1:1, and the mean age 63 years. The estimated amount of ingested phenacetin was 7.1 kg, the estimated mean exposure time 21 years, and the estimated mean induction time 30 years. Renal papillary necrosis and impaired renal function were found in 34 patients. A history of recurrent urinary tract infection was found in 80 per cent of the patients, suggesting that the combination of phenacetin‐abuse and chronic inflammation might be responsible for the localization of the tumours to the bladder. The majority of the bladder tumours were of low grade (1 and 2); muscular invasion was seldom found and metastases were rare. The patients were followed for 1.5–13 years. Twenty‐six patients died; the mean survival time was 46 months. Uremia due to analgesic nephropathy was the main cause of death in 14 patients and contributed to death in another 7 patients. Three of the patients with ureteral tumours had received radiological treatment against the pelvic region, 15–20 years prior to the diagnosis of the uret

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03892.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Fifty‐four primary cases of medullary carcinoma of the thyroid (MCT) traced in Norway, 1960–74, were studied. The mean annual incidence rate was 0.1 per 100,000; the frequency of the tumour among all thyroid carcinomas registered in Norway was 3.4 per cent. The study of the geographical distribution of cases revealed a significantly higher proportion in rural than in urban areas, and in coastal as compared with inland counties. There was also an unexpected accumulation of cases in a few sparsely inhabited valleys in the southern and western part of the country. The familial occurrence of the disease was investigated by means of the family history, pedigree studies and measurement of immuno‐reactive calcitonin (iCT) in serum of relatives. The family history was found to be of limited value in discriminating between familial and sporadic cases. Family screening with serum calcitonin measurements revealed hypercalcitoninemia in relatives of 4 probands, 2 of which were apparently sporadic. Through pedigree studies it became evident that 15 probands were distantly releated to one or two of the others, and the study of grandparents' origin revealed that 16 additional probands had one or more grandparents originating in the same rural municipality as the grandparents of at least one of the others. The high degree of inbreeding in these areas makes it possible that some, if not all, of these 16 probands in fact are genetically related. The pattern of inheritance was in one, possibly in two kindreds, consistent with autosomal dominance. In three other kindreds an autosomal recessive trait is discussed. The familial and also the geographical relationships demonstrated in the other probands may also be an expression of genetic etiology. The nature of this is not clear, but it does not fit in with simple Mendelian inheri

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03893.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

To show what damage occurs in the hepatocytes of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 24 psoriatics with severe psoriasis before and after MTX therapy were studied blind by light and electron microscopy. We also aimed to determine the severity of lesions and find possible correlations, and to seek a relationship of these observations with light microscopical and clinical findings. The present study has shown that MTX probably caused damage to the hepatocytes reflected in the membrane whorls (p<0.05) and the accumulation of lipid droplets (p<0.05). There was an increase (p<0.05) in autophagic vacuoles, which mostly contained glycogen and cell sap with residual bodies. These residual bodies were then found in an increased number in the nearby Kupffer cells. Crystals were found in megamitochondria in most patients before and after MTX therapy. Some of these crystals were found free in the cytoplasm. Mitochondria containing crystals were shown in autophagic vacuoles, representing possible pathways of their breakdown. Bile canaliculi commonly contained debris but only one patient had evidence of cholestasis. There was no significant change in nuclei, Golgi apparatus, or the endoplasmic reticulum and no statistically significant correlation between the shown changes and the total dose of MTX given.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03894.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

To determinate what damage occurred in the bile ducts of psoriatics receiving Methotrexate (MTX) therapy liver biopsies from 11 patients were studied with the light and electron microscope and compared with normal material. Thick sections (1μm) showed light and dark cells in biliary epithelium and lipofuscin granules. At the ultrastructural level these were confirmed. The lumen of the bile ducts contained debris. The microvilli were decreased in number and damaged forms appeared. Damage to the biliary epithelial mitochondria was widespread and there were foci of intracellular oedema. The Golgi apparatus was hypertrophied and dilated. Atrophic cells were seen. The lateral intercellular spaces were dilated and contained debris and the basement membrane showed zones of duplication. Similar changes were found in the ducts of Hering

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03895.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A clinical and light microscopic study of 11 patients with ancient neurilemmoma is presented. Ancient neurilemmoma is a cellular form of ordinary neurilemmoma, showing nuclear polymorphism and hyperchromasia. Seven patients were female and 4 were male; their ages ranged between 37 years and 81 years, with a median of 59 years. Seven tumours were 2.5 cm or larger in the widest diameter, and had been slowly enlarging for one year or more. All tumours were solitary, encapsulated showing nuclear polymorphism and hyperchromasia without any mitotic activity. The differential diagnosis is discussed. Follow‐up information available on all patients confirmed that the clinical course is benig

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03896.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Brenner tumours of various degree of malignancy were investigated by histochemical methods. The cells lining the cystic cavities in the benign Brenner tumours contained various amounts of PAS‐positive, diastase resistant secretory material mixed with small amounts of sulpho‐ and carboxymucin. The borderline and malignant tumours contained more acidic mucins than the benign tumours. All tumours contained glycogen. Argyrophil and argentaffin cells have not earlier been detected in the Brenner tumours but in this study they were detected in twelve of the 18 Brenner tumours. These cells were not proliferating and therefore Brenner tumour should not be included in the group of APUDo

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03897.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

One benign Brenner tumour and one Brenner tumour of borderline malignancy were investigated by electron microscopy. The cells of the benign Brenner tumour nests and the cells in the borderline tumour were similar in ultrastructure. The intercellular spaces were large and reinforced by a moderate number of desmosomes. The nuclei were round or oval. The nuclear membrane was irregular in shape with deep infoldings corresponding to the characteristic nuclear groovings seen by light microscopy. Only few secreting cells could be found in the benign Brenner tumour. The cystic cavities of the borderline Brenner tumour were lined by nonciliated secreting and ciliated nonsecreting cells. The secretory granules were PAS‐positive and diastaseresistant. The granules stained homogeneously and strongly with the PASM‐method at the electron microscopical level indicating the presence of 1.2‐hydroxyl groups. The Brenner tumours have many similarities to the transitional epithelium and to the Muellerian‐derived tubular structures. The findings support the theory that Brenner tumours are of coelomic origin and develop by direct metaplasia from the ovarian surface epi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03898.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The effect of D‐galactosamine on secretory activity and morphology of isolated rat hepatocytes was investigated: Galactosamine was found to reduce the secretion of lipoproteins (as indicated by the release of free cholesterol and triacylglycerol) as well as the secretion of lecithin: cholesterol acyltransferase (LCAT) and [14C]‐labelled proteins from the isolated cells. The secretion of LCAT was inhibited much more than that of the other secretory products studied. Transmission electron microscopy revealed that galactosamine induced morphological changes in RER, mitochondria and nucleoli. The most striking feature of galactosamine‐treated hepatocytes, however, was the appearance of swollen lysosomes. Some of these organelles measured up to 3 μμm in diameter. Uridine did not abolish the effect of galactosamine upon the secretory activity of hepatocytes. The most conspicuous ultrastructural feature in cells that had been incubated with both uridine and galactosamine was the appearance of large amounts of glycogen. The possibility that galactosamine inhibits glycogenosis is discussed. The rather selective effect of galactosamine on LCAT secretion suggests the use of this compound for the study of the interrelationship between LCAT and lipoprotein se

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03899.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Nasopharyngeal cancer is very common among the Chinese in various parts of the world, particularly Southern China, and frequent in certain other Mongoloid groups in Southeast Asia. Also, the incidence among the Eskimos of the western Canadian Arctic and Alaska is considerably higher than would be expected. This paper reports for the first time the incidence of nasopharyngeal cancer among native Greenlanders, an Eskimo population with some admixture of Caucasian blood. During 1955–1976, thirty‐five cases of nasopharyngeal cancer were diagnosed. Ninety‐four per cent (33 cases) were squamous cell carcinomas, including lymphoepitheliomas. Incidence rates 1965–1976, age adjusted to the “world” population distribution, were 12.3 and 8.5 per 100,000 per annum for males and females respectively. These rates are among the highest recorded in the world and significantly higher than among the Caucasian population in Denmark. Compared with other high risk populations nasopharyngeal cancer among Greenlanders had an older age distribution and a lower male‐to‐female sex ratio. An additional 11 cases with malignant involvement, seemingly confined only to cervical lymph nodes, may have included some undiagnosed nasopharyngeal cancers. Thus the calculated incidence rates of this study could represent only minimum rates. Further research is needed especially with regard to the HL‐A profile and to possible traces of Epstein‐B

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1977.tb03900.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY