摘要:

Radiological and clinical comparisons of multiple epiphyseal dysplasia were made in four children and five puppies. On the basis of these, it is assumed that the disease in children and puppies is closely related. Two six‐week‐old beagle puppies with epiphyseal dysplasia were examined histologically. It was found that bone changes developed primarily in the hyaline cartilage. Two forms of pathological tissue were demonstrated in the cartilage. One was an acellular structureless mass which underwent secondary calcification. The other form was located outside the first and consisted of abnormal intercellular calcified hyaline cartilage. Bones with pronounced stippled radiographical appearance (punctate epiphyseal dysplasia) showed massive calcifications of clear‐cut demarcated acellular masses. Bone with pronounced mottled radiographical appearance (multiple epiphyseal dysplasia) showed zones of abnormal intercellular calcified hyaline cartilage. However, both forms of pathological tissue were found in bones with radiographical stippled calcification and in those with radiographical mottled calcific

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00484.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

An examination of general lung tissue with an electron microscope for asbestos fibres is reported. The 65 cases examined consisted of 33 cases of pleural and peritoneal mesothelioma and 32 control cases. Asbestos fibres were found to be more abundant in the mesothelioma cases than in the controls. The most common fibres detected in the mesothelioma group were amphibole asbestos while chrysotile was the more predominant fibre detected in the controls. The difference in asbestos fibre content obtained between the mesothelioma group and controls is larger than the difference obtained in asbestos body counts made with an optical microscope on tissue from the same cases. In those cases found to be possitive for asbestos bodies by light microscopy amphibole asbestos fibres were the predominant fibre type detected.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00485.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

To propagate bacilli, a suspension ofMycobacterium lepraemurium(MLM) was injected intravenously into 40 outbred albino mice. Pronounced differences were observed in the rate of progression of the infection, and 8 mice representing the clinically observed extremes were histologically examined. Poor clinical condition was found to correlate with the presence of many granulomas and few or no surrounding lymphocytes, indicating weak or absent cell mediated immunity (CMI). Good clinical condition correlated with smaller and fewer granulomas with less bacilli and a pronounced infiltration of small lymphocytes. These observations strongly suggest that outbred mice differ in their susceptibility to MLM‐infection. The basis for this heterogeneity, which bears some resemblance to the spectrum in human leprosy, is assumedtobe the varying capacity of individual mice to mount a cell mediated immune response against the mycobacteriu

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00486.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

The distribution of cell types in the pituitary gland was studied in a consecutive autopsy series of men over 40 years of age. Among 166 individuals, not previously subjected to prostatic surgery or oestrogen treatment, the proportion of PAS‐positive cells was higher in men with hyperplasia or neoplasia of the prostate than among individuals showing a histologically normal prostate. PAS‐positive cell counts were negatively influenced by several factors related to wasting disease, while acidophil cells apparently increased in conditions of acute and severe stress. Using multiple regression analysis, benign prostatic hyperplasia was selected as the only one among histological diagnoses which significantly reduced the variability of PAS‐positive cell proportion, even when the negative influence of other factors had been accounted for. PAS‐positive cell counts did not effectively discriminate between the various forms of abnormal prostatic growth encountered. The data presented indirectly give support to the concept of some form of endocrine derangement in the agei

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00487.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

The frequency of pituitary adenomas was recorded in a consecutive autopsy series of men more than 40 years of age. Among 170 individuals, not previously subjected to prostatic surgery or treatment with oestrogenic hormones, pituitary adenomas were observed in 33 patients (19.4 per cent). The adenomas were mostly small, occupying less than 5 per cent of the section area of the adenohypophysis, and were preferably either chromophobe or mixed acidophil/chromophobe. Using multiple regression analysis, the presence of pituitary adenoma was analysed in relation to the histology of the prostate and several other factors. Pituitary adenomas occurred more frequently in relation to prostatic carcinoma than to other histological groups, and did not show a significant relationship to other factors tested.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00488.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Tissues from 12 oral squamous cell carcinomas were investigated for the presence of blood group antigen A. The antigen reactivity in the carcinomas was compared, by titration, to the reactivity of adjacent normal epithelium included in the same specimen. Normal epithelium always reacted positively. In 6 of 12 specimens the malignant cells gave a completely negative reaction. In 5 specimens there was a patchy distribution of positive reaction on cells within the carcinoma. However, these cells possessed less antigen than the normal epithelial cells at the edges of the surgical specimens. In one specimen the majority of cells in the carcinoma showed no decrease in reactivity. In three cases exhibiting slight epithelial atypia adjacent to the tumour, the reactivity of blood group substances in these areas was found to be higher than in the carcinomas but lower than in the normal mucosa.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00489.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

In a previous reported series of rats, rhabdomyosarcomas developed in the peritoneal cavity after growth and regression of the transplantable Yoshida ascites sarcoma, infected by the microsporidian parasiteNosema cuniculi.These tumours have now been reproduced in a new series of rats under the same conditions and converted into a transplanted ascites sarcoma, with 99 per cent takes and 99 per cent death rate. Subcutaneous transplantation of the ascites tumour is followed by the formation of a solid tumour. The microscopic structure is described.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00490.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Cellular reaction to primary and metastatic gestational choriocarcinoma (CHC) was observed in histological sections from all but one of the 23 patients included in this series. The reaction was slight in 8, moderate in 5, and marked in 9. The infiltrates consisted of lymphocytes and plasma cells. A statistically significant correlation (p<0.05) was demonstrated between the intensity of the reaction and the recovery of the patients. In 8 cases of primary invasive mole (IM), a similar reaction was observed. All these patients recovered. None of the 31 patients had had any treatment before the removal of the histological specimens examined in this study.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00491.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Ninety‐seven, largely consecutive, subjects (59 men and 38 women) in Malmo, a coast town of 250.000 inhabitants in south Sweden, were examined post mortem for pleural plaques and asbestos bodies of the lungs. Two sections and one smear from each lung were examined. Asbestos bodies were found in 47 (32 men and 15 women) and pleural plaques in 29 (26 men and 3 women). Sixteen out of the 32 men with asbestos bodies had also pleural plaques. In 7 subjects, all men, more than 20 asbestos bodies were found; four of these had pleural plaque

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00492.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Light and electron microscopic studies on dogs suffering from chronic interstitial nephritis revealed glomerular lesions characterized by thickening of the glomerular capillary walls and an increase in the mesangium. The thickened capillary walls stained strongly with PAS stain and less with silver methenamine stain. Electron microscopy revealed the presence of subendothelial and occasional subepithelial electron dense deposits in the thickened and split glomerular basement membrane. Degenerative changes were seen in the epithelial as well as in the endothelial cells. Similar but milder lesionswereseen in clinically healthy old control dogs but not in young healthy dogs. The findings emphasize the importance of glomerular lesion in canine interstitial nephritis and supports the hypothesis that an altered immunological mechanism, probably related to ageing, might be pathogenetic in this disease.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00493.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY