摘要:

A special type of vacuoles, called marginal vacuoles, and occurring in the cytoplasm of the follicular epithelium cells in smears from fine needle aspiration biopsy specimens is described. Marginal vacuoles were found to be much more frequent in toxic than in atoxic goiters. The difference was so clear that it was considered to be of some value in the examination of biopsy smears from the thyroid. It is suggested that markedly dilated cisterns of the endo‐plasmatic reticulum are the most likely ultrastructural counterparts of the vacuole

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00282.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A material of 57 primary biopsies exhibiting chronic aggressive hepatitis from 57 patients has been selected from a total consecutive liver biopsy material of 3000. The material is divided into two groups: group 1: 21 patients with abnormal biliary epithelium, group 2: 36 patients without abnormal biliary epithelium. No morphological (apart from the atypical epithelium) or biochemical differences between the two groups have been demonstrated. On the other hand the patients in group 1 are older (all over 45 years of age) than in group 2, just as there is a more pronounced excess of women and a more frequently insidious development of the disease. There is significantly higher incidence of organ‐nonspecific antinuclear factors in group 1 than in group 2, whereas mitochondrial antibodies only is found in serum from one patient. None of the available sera from group 1 and from the female patients in group 2 show presence of Australian antigen but in most of the male patients from group 2 precipitating lines are demonstrated. A morphological follow‐up of slightly more than half of the patients shows a significantly more frequent development of cirrhosis in the group with abnormal biliary epithel

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00283.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In a syngeneic tumour‐host system the disappearance of circulating tumour cells was studied in mice treated with heparin, a coumarin anticoagulant and an antifibrinolytic. The cells were injected intravenously in two doses and blood was drawn from the right heart at intervals after the cell transfusion and inoculated intraperitoneally into new recipients. Only minor changes in the disappearance rate of tumour cells from the blood were obtained by anticoagulant and antifibrinolytic treatment. Thus thrombus formation, if present, cannot play but a minor role for the retention of tumour cells in organs in this system. The coumarin anticoagulant delayed somewhat the removal from the blood of 2 × 106injected tumour cells. This was in contrast to heparin which, if anything, seemed to hasten the removal of the cells from the blo

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00284.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Traumatic brain oedema was induced in rabbits by trephine craniotomy which causes circumscribed thermal injury to underlying structures. The amount of oedema was estimated as the per cent water content in brain as determined after heat combustion. The water content was thus measured in the brain of non‐sympathectomized animals and after bilateral superior cervical sympathectomy, with or without additional trephine traumatization. Changes in brain water simply reflecting altered cerebral blood volume after sympathectomy could be corrected for. Sympathectomy 32 hours before water determination caused about 50 per cent reduction in the amount of traumatic brain oedema. At 5 days the degree of oedema was of the same magnitude as in the non‐sympathectomized animals subjected only to trephination. Fifteen days after sympathectomy the amount extended 50 per cent above that in the trephinized, non‐sympathectomized animals. It is suggested that the cranial sympathetics can modify the extent of a traumatic brain oedema through its action on the cerebrovascular s

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00285.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The early chromosomal progressionin vivowas studied in 5–6 parallel series of passages of 2 primary Rous rat sarcomas (RSV‐SR). Both sarcomas had a normal diploid stemline, no sideline and no deviating cells. During transplantation all series of both tumours showed a heteroploid transformation. There were indications that the initial change in the heteroploid evolution was predetermined with a specificity comprising not only the direction of the heteroploid pathway (hyperdiploidy), but also the karyotype. Thus, among all series of passages derived from the same primary sarcoma, the earliest deviating cells had exactly the same karyotype. In both tumours the early heteroploid evolution displayed the same non‐random and sequential characteristics: gains of chromosome types t, st3and st5, respectively. In the course of the heteroploid evolution the normal diploid cells decreased by a non‐linear process with a slow initiation and a rapid fall. The chromosomal progression from a normal diploid stemline to a heteroploid stemline was related to a histological dedifferen

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00286.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The finer intramyocardial vascular architecture in various forms of cardiac hypertrophy was studied by a combined stereomicro‐angiographic and histological procedure. Significant cardiac hypertrophy was induced by renal hypertension, aortic stenosis and swimming exercise. The training‐induced hypertrophy was reversible. The myocardial vascular architecture was altered in cardiac hypertrophy. There were essential differences in the vascular patterns of training‐induced hypertrophy, on one hand, and hypertrophy secondary to hypertension and aortic stenosis, on the other. The nature of these differences suggested that training‐induced hypertrophy was associated with neoformation of vessels in an otherwise structurally unaltered myocardial vasculature, while the other forms of hypertrophy were dominated by a transformation of the preformed vascular pattern. In the regression of hypertrophy, which took place during the resting period after training, only minor changes appeared in the myocardial vascular

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00287.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The report here submitted renders an account of the results obtained by measurements of the damping of ultrasound during passage from the abdominal surface to the uterine cavity in women in the reproductive age. Ultrasound was emitted from a transmission transducer on the abdominal surface and received by a specially designed miniature transducer introduced into the uterine cavity. The damping was found to average 2.5 dB.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00288.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Light microscopy of rectal mucosa from patients with c. f. could not confirm the occurrence of morphological alterations which have prior been described as characteristic of c. f. Neither could electron microscopy reveal alterations in the fine structure of goblet cells, principal cells and endocrine cells.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00289.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In the course of thirteen years, 5994 postmortem examinations were done, among which six cases of renal cortical necrosis were found. These are classified according to microscopical changes. Only three were registered as complications to obstetric diseases. The manifestation of microfibrin thrombosis is found to bee an essentiel factor in the pathogenesis of the condition. According to the similar findings in the generalized Shwartzman reaction, the pathogenesis of renal cortical necrosis is discussed and it is presumed that this condition is confined to a common mechanism, through a varying clinical picture and apparently different pathogenesis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00290.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

An attempt was made to evaluate experimentally the importance of surface charge characteristics of tumour cells for growth of subcutaneous transplants and for metastasis distribution and growth in a syngeneic tumour‐host system (MCG1‐SS in CBA mice). The effect of nonsubstituted dextran (D) was compared to those of the polycation DEAE‐dextran (DEAE‐D) and the polyanion dextran‐sulphate (DS). Heparin was included in some of the experiments as an additional polyanion. D, DS and heparin increased the net negative surface charge of the tumour cells, while DEAE‐D drastically reduced or reversed it, as determined by cell electrophoresis. When given as intravenous pretreatment, the dextrans caused no significant changes in the total amount of metastases. When added to the cell suspensions, dextran (D) and DEAE‐D increased the total metastasis crop by giving larger pulmonary metastases and increasing the number of tumour “takes” in other organs. In the case of dextran (D), this was parallelled by a tendency to promoted growth of subcutaneously transplanted tumour cells, while DEAE‐D blocked the subcutaneous transplantability of the tumour cells. This effect was reversible and could be removed by DS treatment of the cells. DS treatment alone of the tumour cells did not affect metastasis formation to any significant extent. This was in contrast to heparin treatment which seemed to shunt metastases past the lungs, i. e. the first capillary bed encountered after injection. The lack of DS effect was tentatively explained as an interplay between impaired lodgement in vessels and promoted transplantability. For DS treatment of cells improved their subcutaneous transplantability, evidenced by the quicker growth and larger resulting tumour volumes. Heparin only hastened the growth of subcutaneously transplanted cells. No evidence was found that the dextrans or heparin brought about the differences in transplantability or metastasis formation by altered aggregatability in the tumour cell suspensions. Neither did they affect the viability index determined by dye exclusion of the tumour cells in suspension. DEAE‐D seemed to increase the mechanical resistance of vigourously agitated cells i

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00291.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY