摘要:

Male rats were given 50 per cent of calories as ethanol, whisky, brandy, gin and red wine for 8–9 months together with moderate or low protein and vitamin supply. Histological studies at sacrifice failed to detect signs of hepatotoxicity, but biochemical studies indicated that at least red wine and whisky produced more undesirable effects on the liver than ethano

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01882.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Electron microscopic examinations revealed the presence of myxovirus‐like tubular structures, 200Å in diameter, in the endothelial cytoplasm of the glomeruli in four dogs with chronic interstitial nephritis and in one healthy control dog. The structures were found inside the endoplasmic reticulum and in some longitudinal sections, the tubuli seemed to have a helical or spiral substructure. The morphology and cellular localization of the structures resembled those seen in systemic lupus erythematosus in man, and in cultures of cells from tissue infected with canine distemper. Precipitating canine distemper virus antibodies were not in evidence in dogs in which such structures were demonstrable by electron microscopy while these antibodies were found in other do

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01883.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The content of lymphocytes in blood samples from the splenic vein and the splenic artery of guinea pigs was determined and the veno‐arterial difference in number of cells was used as measure of the net release of cells from the spleen into the blood. The splenic release of lymphocytes was reduced after whole body irradiation with 300 rad. This reduction could partly be prevented by transfusion of bone marrow cells after irradiation, 106cells being the most effective dose. In thymectomized, irradiated animals the restoration of the splenic release of lymphocytes after irradiation was impaired in comparison with sham‐operated animals. In the thymectomized animals the transfusion of 106thymus cells had a restitutive effect on the splenic release of lymphocytes, while transfusion of bone marrow cells or daily treatments with thymosin, alone or combined with transfusion of bone marrow cells, had no such restitutive effect. The results indicate that restoration of the splenic release of lymphocytes into the blood after irradiation is thymus dependent and probably caused by a traffic of lymphocytes from the thymus to the spl

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01884.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The length of the left main coronary artery (LMA) was determined in post‐mortem, non‐fixed hearts of normal weight (heart weight<400 g, group I) and hypertrophic hearts (heart weight ≥ 400 g, group II). Hearts from 76 men and 88 women in group I and 136 men and 61 women in group II were studied.The mean length of LMA in group I was 9.1 mm in men and 8.4 mm in women. Corresponding values in group II were 10.3 mm and 8.8 mm. There was no significant sex difference in the length of LMA in group I, but the sex difference in group II was significant (p<0.01). The difference in length of LMA between groups I and II reveals that the difference in men was significant (p<0.02), but insignificant in women.In the case of both sexes no significant correlation between heart weight and the length of LMA was found either in group I or group II. There was a significant correlation between the area of the left coronary ostium and the length of LMA in men in group I (p<0.05), but not in women. Corresponding comparisons of both sexes in group II were statistically insignif

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01885.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Results are presented of chromosome studies of bone marrow cells from a 62‐year‐old woman. The patient had been given 40 ml of Thorotrast in connection with a neuro‐radiological examination 34 years earlier. Clinically, the patient was now considered to be in an incipient myeloid leucaemic phase. Ninety‐seven per cent of the bone marrow cells belonged to a clone with characteristic marker chromosomes induced by radiation. Few data are available on chromosome analysis of bone marrow cells from Thorotrast patients. Therefore, the results of the present study are compared with data from chromosome analyses of32P‐treated patients with polycythaemia vera, in whom large clones were found in the bone marrow. The results of chromosome analysis of bone marrow cells from the Thorotrast patient support previous hypotheses concerning the carcinogenesis in radiation‐induced leucaemia in patients with polycythaemia vera, treated with32P. In the latter patients, the clone cells are pressumed to represent cell populations with selective qualities, originating from radiation‐damaged cells, which possibly possess an increased tendency to malignant transformation because of a more pronounced sensitivity to carcinogenic agents. The cells might also be potentially malignant and manifest themselves as leucaemic cells, if the patient's immunological defence mechan

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01886.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The mucosal surface pattern of surgical specimens from small intestine affected by Crohn's disease are studied using Alcian‐green staining of whole mounts. The semimacroscopic appearance of the mucosa is described. Our findings include i.a. malformation and enlargement of villi—often to extreme degree–villi frequently showing small vesicles on their apical region. Polypoid structures were found to be avillous as well as covered by normal or abnormal villi. The semimacroscopic observations are compared with observations from conventional light microscopy. The villus enlargement is in the first stages caused by lymphatic dilatation and later by oedema and inflamm

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01887.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A method giving highly purified zymogen granules fromMacaca irusandCercopithecus aethiopsparotid glands is reported. A 0.3 M sucrose medium for homogenization was supplemented with 10 mM tris/HCl, pH 7.3, and 0.1 mM lauric acid to stabilize the fragile monkey zymogen granules. Nuclei and cell debris were sedimented at 150 ×g.A “crude” zymogen granule fraction was trapped in the 1.0 M sucrose layer of a discontinuous sucrose gradient at 1000 Xg.Equilibrium centrifugation in a continuous sucrose gradient gave a fraction of zymogen granules at 1.85 M sucrose. Compared to the homogenate, this fraction exhibited about two‐fold increase in zymogen granule marker, whereas mitochondrial marker was reduced to 1/4 and lysosomal marker to 1/2. A low level of contamination from other cell organelles was confirmed by electron microscopic investi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01888.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

After subcutaneous isotransplantation of renal medulla either from normal donors or from the ischaemic kidney of renal two‐kidney hypertensive rats, the blood pressure of the renal two‐kidney hypertensive recipients was lowered—but not to normal levels. After i.v. injection of the converting enzyme inhibitor SQ 20,881, the blood pressure was further decreased to, or close to, normal blood pressure. A complete normalization of the blood pressure was obtained by the combined treatment with medullary transplants and infusions of the angiotensin II inhibitor Saralasin. The difference between the effects of these two blockers was probably caused by differences in the doses used. Administration of indomethacin, an inhibitor of the prostaglandin biosynthesis, to renal two‐kidney hypertensive rats with or without renomedullary transplants failed to provoke a rise in blood pressure. This indicates that the anti‐hypertensive activity of renomedullary transplants is not due to the group of prostaglandins, the synthesis of which is inhibited by indomethacin, and furthermore that these prostaglandins are not of importance to the blood pressure level in renal two‐kidney hypert

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01889.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

As a part of an experimental study of the spread of urogenital infections, male guinea pigs and mice were intravenously injected with a sublethal dose ofCandida albicansin a long‐time experiment. The kidney was the organ of maximum infection. Spread in the kidney was observed from the cortical and glomerular capillaries, where the injected yeast cells first lodged, but after pseudomycelial transformation penetrated into the Bowman's space andintothe lumen of the tubuli. Guinea pigs recovered from the infection. In mice the renal candidiasis progressed and two types of the disease could be distinguished: an acute type with cortical abscesses and a chronic type with partly necrotic tips of the pyramids and adhering fungal masses in the pelves. A similar picture has been observed in man. The pathogenesis of renal candidiasis seems to resemble that of renal tuberculosi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01890.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

As part of an experimental study of the spread of urogenital tuberculosis, the development of tuberculous infection was compared in vaccinated and non‐vaccinated guinea pigs after challenge withMycobacterium tuberculosisstrain H37Rv into the seminal vesicle. The animals were saccrificed 35 days after challenge. Morphological observations indicate that tuberculous infection in an immunized animal is retarded, but spreads by the same routes as in an non‐immunized animal. On microbial enumeration significantly lower numbers of organisms were recovered from the inoculated seminal vesicle and regional iliac lymph nodes of the BCG‐vaccinated guinea

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01891.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY