摘要:

Small arteries of the gastric wall of one patient with pseudoxanthoma elasticum (PXE) and four patients without this disease were examined. For comparison skin of normal appearance from light‐protected areas of 5 PXE and 5 non‐PXE patients was studied. In some of the gastric arteries of the PXE patient, the internal elastic lamina and surrounding tissues showed the typical ultrastructural alterations seen in PXE skin lesions,i. e.large irregular calcium deposits inside and around elastic tissue, and, in the surroundings, a thready material of unknown nature and twisted, partly split, collagen fibrils. In addition, calcification of collagen was observed. “Senile” degeneration of the internal elastic lamina of gastric arteries and of dermal elastic fibres was observed in the controls as well as in the PXE patients. No typical PXE change could be demonstrated in elastic tissue without histochemical evidence of calcification. In PXE, calcification of the internal elastic lamina of gastric arteries seemed to precede a severe degeneration as well as a disruption of the internal elastic lamina and an irregular thickening of the

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00338.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A study of the morphology and staining reactions of Mallory bodies is given on the basis of a consecutive series of 62 liver biopsies with Mallory bodies. Two types of Mallory bodies are described according to size and age. The differential diagnostic problems are discussed and the histological changes in liver biopsies containing Mallory bodies are described.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00339.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Successful heterotransplantation is reported for 3 out of 4 human epidermoid carcinomas, consecutively transplanted to the mouse mutantnude.Serial transmission was obtained in two cases, so far for 2–5 passages. Tumours grew locally in mice, and no metastases were observed. Histological and cytological appearance of the grafts were in full accord with the original human tumour. The mouse mutantnudeis suggested as a host for human epidermoid carcinomas in the study of oncostatic agent

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00340.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Among 9 patients with secondary systemic amyloidosis, 8 had amyloid deposits in the skin. Amyloid was found in the deepest part of the dermis around the adnexa and in the subcutaneous tissue in the form of rings around fat cells. The amount of amyloid varied somewhat between different skin areas and, among the parts of the body examined, the scalp and the abdominal skin showed the heaviest infiltration. It is obvious that secondary amyloidosis can be diagnosed by means of skin biopsy in many cases.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00341.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The camera lucida drawing method with planimetric area measurements was compared with direct microscopy and systematic point count in a quantitative study of glomeruli, the study including differential counts of nuclei and determination of the total and mesangial areas. Good reproducibility was found using both methods, but the camera lucida drawing method was found to be at least three times more time‐consuming than direct microscopy for total and differential counts of nuclei and systematic point count for mesangial area determination. Measurement of total glomerular area was done planimetrically, by point counting and by determination of the area as an ellipse or a circle. The results obtained planimetrically and by point counting did not differ significantly, whereas the difference between the results of the planimeter measurements and the results obtained by applying the formula of an ellipse or a circle on glomerular sections was found to be statistically significant. If central sections were compared with random sections of glomeruli, deviation of results was found to be greater in the random sections, and it was calculated that 10 central and about 30 random sections have approximately the same value in quantitative examination of a renal tissue specimen. Thus, it appears advisable to use direct microscopy for total and differential counts of nuclei, systematic point count for mesangial area determination, planimetric measurement or point counting for total glomerular area determination and to apply this method on central sections of glomerul

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00342.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

An unselected autopsy series of 71 patients was investigated for the occurrence of cardial colloid. The change was found in 51 per cent of the cases (36 patients). The different types of the morphology and histochemistry of cardial colloid are described. A similarity between the chemical composition of cardial colloid and amyloid was found, and possibly the pathogenesis of both substances has much in common. In one fourth of cases of cardial colloid small amyloid precipitates were found in the alveolar septa and arteries of the lungs. As cardial colloid more often is found in old age the change possibly bears relationship to senile amyloidosis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00343.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Mitotic waves were released in kidney tubules by resecting one kidney and a half in a group of 4 rats at intervals of a few hours during the 24‐hr‐cycle. The course of the mitotic wave appearing on the second day after the operation was followed in each half‐kidney by determining the incidence of mitosis at intervals of 3 hours. The waves showed a distinct diurnal pattern of variation: those initiated by resection between noon and midnight had single peaks, while those initiated by resection between 3 a.m. and 9 a.m. gave waves with 2 peaks. It is assumed that the single as well as the paired waves are based mainly on mitoses in the proximal tubules. The alternation between sequences of single‐ and double‐peaked waves through the 24 hours is interpreted as the result of an interference of an endogenous mitotic rhythm, the mitotic wave starting slightly less than 30 hr after the

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00344.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The uterus, oviduct, vagina, mesometrium and ovary of mature rabbits all contain renin, by far the highest concentrations being found in the uterus and in the isthmic segment of the oviduct. In contrast to the uterine renin the concentration of the oviduct does not increase significantly during maturity or terminal pregnancy, while oestradiol administration results in a marked increase in both uterus and oviduct. Surgical separation of the oviduct from the uterus results in some decrease, but not disappearance of the renin in the oviduct. Intraocular grafts of oviduct in immature, oestradiol treated and in mature, hysterectomized animals contain renin concentrations equal to or higher than those of the oviductin situ.These findings show that the oviduct contains renin‐producing cell

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00345.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A case of delivery complicated by extreme hyperlipaemia, probably of the Friederickson type IV, is reported. We found numerous foam cells in the placenta, mainly concentrated at the edge of the fibrin deposits in the intervillous space. In our opinion, based on the results of light microscopical, histo‐chemical and electron microscopical examinations, the foam cells are free macrophages originating from the maternal circulation. No other essential histological changes were found, and the placenta functioned adequatel

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00346.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

As part of a comprehensive study of the testes, the pituitary gland and the adrenal glands in relation to abnormal growth of the prostate, the occurrence of benign nodular hyperplasia (BNH), carcinoma (C), diffuse atrophy (DA) and normal histology (N) of the prostate was studied in a consecutive series of 206 men over 40 years of age submitted to necropsy. Atypical glands without obvious invasive properties were recorded separately and termed atypical glandular proliferation (AGP). The occurrence of BNH and C were both strongly related to age. BNH was the most frequent histological pattern encountered (80.1 per cent), and after the age of 70 years, BNH was observed in practically all cases. C was observed in 70 patients (34 per cent) and was an incidental finding at autopsy in all but four cases. After the age of 80 years, 52 per cent carried C. The great majority of carcinomas were small and were located predominantly in the peripheral zone of the prostate. The frequency of C in patients previously operated upon for BNH was similar to that in non‐operated patients. The frequency of BNH in prostates with C was not different from that to be expected as a purely coincidental occurrence. The location of AGP resembled that observed for C. However, the simultaneous occurrence of AGP and BNH was more frequent than that to be expected as pure coincidence. Whether AGP represents benign or potentially malignant lesions remains obscure. The classification of AGP as a benign lesion or carcinoma may markedly influence the prevalence ratios of latent prostatic carcinoma in autopsy series. In patients dying from cardiovascular disease, BNH occurred more frequently, and C less frequently, than what would be expecte

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00347.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY