摘要:

The distribution of lysozyme in the serum, urine and kidney homogenates was studied in normal young (less than 4 months) AKR mice, in old (more than 8 months) AKR mice that bore a spontaneous lymphocytic leukemia and in young AKR mice in whom this leukemia had been transplanted. Much higher concentrations of lysozyme were detected in the kidney homogenates of the old mice than among the young mice. However, after the injection of leukemic cells into the young mice, increased concentrations of lysozyme were detected in their kidneys as well. Concentrations of lysozyme in the serum did not vary markedly in either age group or during the course of leukemic cell proliferation. During the pathogenesis of the transplanted leukemia, morphological changes were observed within the proximal tubular cells of the kidneys by light microscopy, and by the cytochemical demonstration of lysozyme using an immunoperoxidase technique. The number and size of dense and lysozyme‐positive granules of the proximal tubular cells increased concomitantly with the increase in lysozyme levels in kidney homogenates. Lysozymuria developed in the advanced stages of the disease and was associated with morphological signs of tubular cell damage. The findings of elevated lysozyme levels in leukemic mice are discussed as a phenomenon related to the stimulation of the reticuloendothelial system induced either by the injected leukemic cells or by the viral agent associated with this lymphocytic leukemi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00392.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The biochemical activity of lysozyme and the immunohistochemical cellular localization of lysozyme were studied in germ‐free and conventionally reared rats. In comparison to conventionally reared rats, germ‐free rats had significantly lower concentrations of lysozyme in the salivary gland, duodenum, colon, spleen, bone marrow and serum. Lysozyme concentrations were also lower, though not significantly so in the lung and the liver. By contrast, increased levels of lysozyme were observed in the thymus and ileum of germfree in comparison with conventionally reared rats. No lysozyme was detected in the urine or in the intestinal content of the ileum or the colon of either group. Lysozyme was detected by immunoperoxidase staining in the proximal tubules of the kidney, in the alveolar macrophages and in the Paneth cells of the small intestine in both germ‐free and conventionally reared rats. However, in the Paneth cells of the ileum an increased intracellular concentration of lysozyme was observed in the germ‐free rats. Moreover in the thymus of germ‐free rats, lysozyme‐positive reticular cells were observed that could not be localized in the thymus of conventionally reared rats. In addition to the observed low levels of immunoglobulins and complement, a relative lack of lysozyme could play a part in the increased susceptibility to infection of ger

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00393.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In rats with acute angiotensin‐induced hypertension, segments from intestinal submucosal arterioles dilated and permeable to plasma components were studied in the electron microscope. The permeability pathways were found to be endothelial gaps measuring from 900 Å to 29 microns, discontinuities of the endothelial basement membrane, fenestrae in the internal elastic lamina and discontinuities of the luminal basement membrane of the media. Most of the endothelial gaps were shown to be dilated endothelial junctions, and colloidal carbon and formed elements of the blood were found passing through the gaps. In media, carbon was found extra‐ and intracellularly if the smooth muscle cells were severely damaged. Penetration of carbon into the adventitia was not found when the adventitial basement membrane of the media was intact. The changes are probably caused by mechanical factors secondary to the development of dilatat

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00394.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The hyaline or “fibrinoid” material deposited in glomerular capillaries and minor vessels of the corium in association with swine salmonellosis, an experimental model of the generalized Shwartzman reaction, was found to be derived predominantly from disintegrated red blood cells. Severe stasis with excessive vasodilatation preceded the erythrocytic damage. Massive haemolysis did not seem to take place; the stagnant and tightly packed red cells in the engorged vessels were submitted to various types of disintegrating processes, the ultimate result being partial lysis. It is suggested that this erythrocytic debris corresponds to the hyaline masses which frequently stain as fibrin in conventional histological secti

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00395.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The ultrastructure of intestinal submucosal arterioles in rats with angiotensin‐induced hypertension was examined. Dilated arteriolar segments showed focally localized severe changes (“patches”) with gaps in the endothelial cell layer and with discontinuities in the endothelial basement membrane, the internal elastic lamina and the luminal basement membrane of media. Through the discontinuities, plasma, formed elements of the blood and injected carbon particles penetrated into the arteriolar wall. In the patches, severe injury and slighter degenerative changes were observed in all layers of the vascular wall, Lesions were most extensive in the media and showed a gradient in severity of changes from the centre to the marginal zone of the patches. The observed changes were results of smooth muscle cell necrosis and plasma insud

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00396.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In 97 patients with ulcerative colitis, representing a large clinical spectrum of the disease, liver disorder was assessed by estimation of percutaneous liver biopsy. Thirty‐nine patients presented histological changes—the greater part of minor degree—, i.e. an incidence of abnormal liver histology in ulcerative colitis in 40 per cent (95 per cent confidence limits 30–51 per cent). Antibodies against mucous‐containing cells of the colon epithelium, detected by the immunofluorescence technique and without correlation to histological liver disorder, were found in 19

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00397.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

This paper demonstrates lobular involvement of two morphological different types: Lobular carcinoma in situ and carcinomatous extension to the lobule in 70 non‐selected cases of invasive breast carcinoma. Carcinomatous involvement of the lobules was found in 34 cases. In 16 of these cases, it was not possible to distinguish the lobular changes morphologically from lobular carcinoma in situ whereas, in 13 cases, carcinomatous extension to the lobules was found. In 5 cases the type of carcinomatous involvement of the lobules could not be established with certainty. In the 16 cases with lobular carcinoma in situ, 5 of the lesions were found at the edge of the invasive carcinoma, 4 were completely outside the tumour area, and in 7 cases the lesions were found both at the edge and completely outside the tumour area. In 59 per cent of cases the lesions were multicentric. Thirteen of the 16 cases presented lobular carcinoma in situ also in the upper quadrants. The diameter of the tumour was not related to the occurrence of lobular carcinoma in situ or to carcinomatous extension to the lobules. On the other hand, lobular carcinoma in situ was most frequent in highly differentiated carcinomas. A more detailed study of the biology of lobular carcinoma in situ, associated with invasive breast carcinoma, is considered necessar

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00398.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

During a follow‐up period averaging 17 years (2–30 years), 64 breast tissue specimens were removed in 52 females with lobular carcinoma in situ of the breast (LCIS) before, simultaneous with or subsequent to the detection of LCIS. In 8 out of 25 cases the LCIS was bilateral, and in 9 out of 19 it was multicentric. The present study does not reveal the actual multicentric and bilateral appearance of LCIS, but the “spontaneous” appearance in a series of specimens which were not removed or investigated primarily with the object of detecting this breast

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00399.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In 52 cases of lobular carcinoma in situ of the breast (LCIS) without simultaneous invasive carcinoma, the actual lesion and the adjacent breast tissue were evaluated histologically and the findings related to the overall occurrence of invasive breast carcinoma. No single histological parameter appeared to any significant degree in cases with invasive carcinoma, whereas, in a few instances, this was the case when certain parameters were found concurrently. However, with our present knowledge, the result of a histological subclassification of LCIS cannot be decisive in the choice of treatment. Out of the 52 cases, 49 had fibro‐adenomatosis concurrently; of these, 6 were of a high degree of severity, 4 had fibroadenoma, 1 had papilloma, 8 had ductectasia, 5 non‐specific mastitis and 2 fat necrosis. Only occasionally was intracellular mucin found in cases of LCIS, whereas PAS‐positive material was frequent. In a few cases very large mast cells were seen in the adjacent stroma, but the significance of this finding remains unclar

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00400.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The content of renin in rabbit uterus is known to increase many fold during pregnancy followed by a rapid fall to normal levels within a few days after delivery. In order to study this mechanism the blood concentrations of renin and its substrate were measured. Contrary to the concentration of renin in uterus, the plasma renin concentrations were not increased either during pregnancy or in the post partum period. The renin‐substrate concentration was unchanged during the first part of pregnancy but was increased 2–3‐fold in the days around delivery. This increase resulted in a corresponding increase in plasma renin activity. It was concluded that the rapid inactivation of uterine renin post partum was due to a local inactivation and not to a release of renin to the

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00401.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY