摘要:

The effects of both early mobilization and immobilization on the healing of a crush injury in the rat gastrocnemius muscle were studied histologically. A reproducible injury was induced on the left calf of 242 rats. The histological observations were made 2 to 42 days after the injury and the intensity of the changes was estimated semiquantitatively by scoring. During the first week, the histological changes were especially dependent on the post‐traumatization treatment. The inflammatory reaction and haemotoma formation were more pronounced in the mobilized muscles and the amount of necrotic and degenerated muscle tissue was more in the immobilized muscles. The disappearance of the haematoma and of the inflammatory cells occurred more rapidly with mobilization. Scar formation was more pronounced in the mobilized injuries. Immobilization for the first 2–5 days after the trauma was followed by a slight delay in the maturation and contraction of the fibrous scar. Muscle regeneration was more extensive and occurred more rapidly in the mobilized muscles. The penetration of regenerated muscle fibres through the scar was more pronounced in the immobilized muscles, but the orientation of the new fibres was more parallel with the original muscle fibres after mobilization. The histological differences between the treatment groups diminished markedly towards the end of the observation per

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01874.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Intravenous injections of disintegrated cells ofEscherichia coliin chickens were almost constantly followed by extensive lesions in pulmonary arteries; the alterations consisted of mural fibrinoid necrosis, sometimes with slight intramural occurrence of mononuclear inflammatory cells and eosinophils. Massive perivascular accumulations of the same cell types were also very common findings. Affected arteries were frequently occluded by precipitates, predominantly consisting of the injected material, which were rapidly replaced by proliferating endothelial cells, resulting in obliterative lesions, where giant cells sometimes occurred. The conclusion was drawn that the arterial lesions could most adequately be categorized as hypersensitivity angiitis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01875.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Tissue from 40 oral premalignant lesions were investigated for the presence of blood group antigens A and B. The material included 18 leukoplakias, 1 erythroplakia, and 3 lichen planus, all with varying degrees of epithelial dysplasia, and 18 leukoplakias without histological evidence of impending malignancy. Thirty‐eight benign keratotic oral mucosal lesions were included as a control group. The antigens were demonstrated by a double layer immunofluorescence technique, and the reactivity was compared, by titration, to the reactivity of adjacent normal epithelium from the same patient. All 22 lesions with dysplasia showed decreased reactivity for blood group antigen. Among the 18 leukoplakias without any signs of impending malignancy 4 cases demonstrated loss of antigen reactivity. None of 38 benign control lesions showed any change in antigen reactivity as compared to normal adjacent epitheliu

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01876.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

In 23 cases of perimembranous glomerulonephritis (PGN, membranous nephropathy), the juxtaglomerular cell complex (JGC‐complex) in early postmortal (2 cases) and bioptically obtained specimens (21 cases) was investigated quantitatively by planimetry. The results were correlated with the stage of the PGN and the clinical findings. A statistically significant increase in mean size of the JGC‐complex was found in perimembranous glomerulonephritis compared with the control group (p<0.005). Comparing the different morphological stages of PGN, the size of the JGC‐complex was increased and the serum creatinine level raised in stages 3 and 4. In hypertensive patients with perimembranous glomerulonephritis, the serum creatinine levels were significantly raised as compared with the normotensive

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01877.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The pathology of primary familial amyloidosis with polyneuropathy is described on the basis of post‐mortem examination of six cases from Northern Sweden. Clinically the disease is characterized by progressive sensory and motor disturbances with loss of sensation, muscular wasting and flaccid paralysis. Impotence, urinary bladder dysfunction, motility disturbances of the gastro‐intestinal tract and postural hypotension indicate affection of the autonomic nervous system as well. Malabsorption, cardiac insufficiency and vitreous opacites also occur. As regards the distribution of amyloid, the following findings seemed to be characteristic. Usually there were no gross lesions indicating the amyloid disease. Histopathologically, amyloid deposits were observed in great extent in the peripheral nervous system and in various parts of the peripheral autonomic nervous system as well. It occurred extensively in the walls of blood vessels of various calibres, in the perivascular collagenous connective tissue and adjacent to the smooth musculature. Amyloid deposition was also found more or less abundantly in various other organs and tissues. No deposits, however, or only insignificant amounts, were found in the central nervous system, either in the parenchyma of the liver, in the islets of Langerhans, or in the bone marrow. Clinical manifestations seemed to be related to the local deposition of the amyloid substance. Our clinical and pathological findings in this particular type of familial amyloidosis conformed mostly to those previously descri

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01878.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The effect of temperature on the development and maintenance of long‐term cell adhesion was studied. Cell metabolism appeared to be essential for the maintenance of long‐term cell adhesion at 37°C. The maintenance of cell adhesion at low temperatures, however, was less dependent on cell metabo

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01879.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The transplantabilities of trypsin and neuraminidase‐treated 101‐AA cells were compared with untreated cells. The cell doses required for growth were similar for enzyme‐treated and control cells. Yet, trypsinized cells injected i.v. gave rise to less lung tumours and, in one experiment, they produced more extrapulmonary tumours than control cells or neuraminidase‐treated cells. These findings were collated with some data on the effect of enzyme treatment on the tumour cell membranes, obtained by particle size analysis, cell electrophoresis, lectin agglutinability and sialic acid determinations. The importance of cell surface characteristics for specific metastasis patterns, in this case a peculiar “myotrophism”, i

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01880.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Two elderly women with gradual enlargement of the leg following paralytic poliomyelitis are reported. From the clinical appearance, plain radiograms and angiographic studies the enlargement was thought to be caused by adipose tissue. On exploration the muscles within the calfs were found to be entirely replaced by adipose tissue. Histological examination revealed diffuse lipomatosis involving skeletal muscle, fasciae and in one case even periosteum and bone. Peripheral nerves exhibited fibrosis and myelin degeneration and vessel walls showed unusual angioma‐like changes. Since it is known from the literature that peripheral nerve lesions of different kinds can be followed by adipose overgrowth we believe that there is a pathogenetic relationship between poliomyelitis and the diffuse lipomatosis in the present case

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1975.tb01881.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY