摘要:

A splenic factor was prepared from a saline extract of calf spleen by čentrifugation at high speed, heat precipitation and aceton precipitation. The factor had an inhibitory effect on the DNA synthesis of lymph node cells and thymus cellsin vitro.The possibility that the factor is a T cell chalone is discussed

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00371.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Left renal artery stenosis was produced in a group of rats. In a second group left renal denervation was performed simultaneously with and in a third group 3 weeks before the stenosing operation. In a fourth group of rats only left renal denervation was performed. The rats were studied with respect to blood pressure and histochemically demonstrable adrenergic nerve patterns in the left kidney. In rats with left renal artery stenosis and hypertension the adrenergic nerve pattern in the left kidney was abolished during the early phase of the blood pressure elevation. The nerves were rendered visible after incubation of kidney specimens in α‐methyl‐norepinephrine. A significant number of rats with left renal artery stenosis and histochemically proven complete left renal denervation developed hypertension. It is concluded that the adrenergic innervation of the juxta‐glomerular cells plays a moderatory but dispensable role in the sequence of events leading to an increased renin release with concequent hypertension in renal artery st

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00372.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Amyloid formation in caseinated C3H mice is enhanced by the administration of dibutyryl cyclic AMP (3′, 5,‐adenosine monophosphate), by the phosphodiesterase inhibitor theophylline and by combination of these two compounds. One beta receptor stimulator, soterenol, also enhanced amyloid development, but several other α and β receptor active substances tested were without effect in the dose used. It is hypothesized that a sustained elevation of intracellular cyclic‐AMP level can make cells produce

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00373.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Female mice of the outbred strain NMRI, and the five inbred strains AKR, BALB/c, C3H, C57/BL, and White Label were infected withMycobacterium lepraemurium.Infectious lesions in the liver were evaluated histologically with regard to the type of inflammatory reaction and content of bacilli. In the outbred strain the host response of individual mice varied considerably. This variation diminished if a large inoculum was used and the infection allowed to proceed for a long time. Within the inbred strains individual animals showed a more uniform type of reaction. However, clear differences in the host response to murine leprosy could be demonstrated in these strains, most markedly between the strains C3H and C57/BL. In C3H, the infection seemed to make uninhibited progress and the granulomas contained large numbers of bacilli with few or no surrounding lymphocytes. The granulomas of C57/BL mice contained fewer bacilli and regularly showed infiltration by lymphocytes. However, after a large inoculum of bacilli this difference in host response seemed less evident. The present study confirms our previous observation that outbred mice differ in their host response to murine leprosy. Evidence is presented that this variation is due to differences in the ability of individual mice to mount a cell mediated immune response against the mycobacterium. The capability to respond is shown to depend on genetic factors of the host.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00374.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The autoradiographic pattern of the cervix epithelium after iterated application of the carcinogen 3,4‐benzpyrene was investigated in 100 C57B1 mice. There was a gradual increase in the proportion of labelled cells with increasing degree of atypias. Labelling of superficial layers occurred in almost all cases with severe atypias (grade III) and in 8 per cent of those with moderate atypias (grade II). The labelling of superficial cells in moderate atypias (grade II) suggests that, despite cytoplasmic maturation, their nuclei retained the property of less mature or of undifferentiated cells, i.e. the capacity to synthesize DNA. The highest number of labelled cells was found in mice presenting severe atypias with epithelial buds protruding into the strom

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00375.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Two groups of liver biopsies with fatty change, one with and one without Mallory bodies, are compared morphologically, and the corresponding groups of patients are compared biochemically and clinically. Both the morphological and the biochemical activity are greater in the group with Mallory bodies, and, as the morphological follow‐up shows a significantly more frequent development of cirrhosis in the group with Mallory bodies, there is good reason to believe that Mallory bodies and alcoholic hepatitis give rise to development of connective tissue in the parenchyma and are the common cause for development of cirrhosis in alcoholics with livers exhibiting fatty chang

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00376.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The use of rabbit anti‐rat thymocytic serum (ATS) as immunosuppressant was investigated in the heterotransplantation of HeLa‐cells into rats of different ages. The transplantation was carried out by subcutaneous injection of HeLa‐cell suspension. The first intraperitoneal ATS injection was given on the same day and the subsequent injections were given 2, 4, 7, and 10 days later. On day 14, the rats were killed and the tumour growth was estimated by the size of the nodule and several histological criteria. 0.005 ml ATS/g body weight given every time was observed to be sufficient to give a tumour growth in all animals aged less than 2 days. A considerably bigger dose, 0.04 ml ATS/g body weight, did not further enhance the tumour growth or change the host reaction. However, this dose caused a much higher mortality of animals. 0.0005 ml ATS/g body weight did not cause adequate immunosuppression for transplantation of HeLa‐cells. In experiments with older animals given 0.005 ml ATS/g body weight, the transplantation result in 7‐day‐old rats was comparable to that in younger rats, but clearly poorer results were obtained in 24‐day‐old rats. It is concluded that adequate immunosuppression for the growth of HeLa‐cell tumours in rats 7 days old or younger was achieved by a dose of ATS sufficiently small for p

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00377.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Fluoride supplement of 10 mg of fluoride per kg body weight per day given to growing rabbits during 14 weeks until skeletal growth had ceased resulted in the development of typical skeletal fluorosis. Withdrawal of this supplement resulted in normalization of bone morphology after 52 weeks,viz.during adulthood. At that time, the bone fluoride concentration was nearly the same as that at the time of withdrawal (about 0.70 per cent of ash). Thus, bone remodelling and maturation did not result in any marked elimination of F‐from the bone minera

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00378.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Splenic metastases were found in 312 cases (7.1 per cent) in a uniformly examined post mortem series where it was possible to compare the frequency of metastases in different organs. This frequency is comparable to, and in many cases higher than, the frequency of metastases in other organs with a corresponding risk of being the site of blood‐borne metastases. The investigation does not suggest that the spleen has a greater antiblastic effect than other organs. The metastases were divided into ten different types depending on their localization in the spleen and whether they were diagnosed macroscopically or microscopically or both. Apart from type IV which probably consisted of continuous retrograde growth in trabecular lymph vessels and which cannot be regarded as true remote metastasis, the pattern of metastases suggests that splenic metastases are the result of hae‐matogenous spr

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00379.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Among 284 cases of haematogenous splenic metastases, haemopoiesis was demonstrated in the spleen in 38.0 per cent. Blood formation was found in 17.4 per cent of the cases without, and in 47.9 per cent of the cases with skeletal metastases (p<0.001). Among the cases with skeletal metastases, extramedullary blood formation was demonstrated in 68.7 per cent of those presenting involvement of all the vertebral bodies compared with 25.8 per cent of the remainder (p<0.001). The latter frequency (25.8 per cent) did not differ significantly from that (17.4 per cent) found among cases without skeletal metastases. The occurrence of skeletal metastases therefore appears to be of little importance in cases without extensive destruction of the bone marrow. Among cases with metastases inallthe vertebral bodies, the frequency of extramedullary blood formation did not vary significantly with the type of metastases. Among other cases with or without skeletal metastases, extramedullary blood formation was more common among cases with sinusoidal metastases. This finding must, however, be judged with caution.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1974.tb00380.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY