摘要:

Hypertrophy and focal nodular hyperplasia with tumour‐like proliferation of the C‐cells was observed in thyroid tissue removed from a 64‐year‐old male with non‐toxic adenomatous goitre and primary hyperparathyroidism. The patient was found to have an enlarged parathyroid gland consisting exclusively of waterclear cells. It appeared likely that chronic hypercalcaemia had been responsible for the C‐cell proliferation. Morphological similarities between the thyroid change of the present case and the early stages of some forms of medullary thyroid carcinoma suggest that this neoplasm could arise from hyperplastic foci of C‐cells. It is emphasized that chronic hypercalcaemia may beoneaetiological factor in human C‐cell neoplasia, including some types of medullary carcinoma. This implies that medullary carcinoma might have been secondarily induced by the parathyroid adenoma in some of those patients in whom both of these manifestations have b

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00319.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Patients with medullary thyroid carcinoma may show two histochemically different populations of non‐follicular cells in those parts of the thyroid parenchyma as are not involved by the neoplasm. Besides cells with characteristics consistent with C‐cells (basic dye metachromasia and argyrophilia), there is a second, topographically and morphologically distinct population of extra‐follicular cells which show argentaffin and orthochromatic cytoplasmic granules. These cells were found in 13 out of 25 cases of medullary carcinoma and they were also present in parathyroid glands in 5 out of 8 of these patients. Their malignant counterparts in the tumours were found in 20 out of 34 cases. Argentaffin and orthochromatic cells were only sporadically seen in a series consisting of various benign thyroid diseases and they were totally absent in cases of malignant neoplasms other than medullary carcinoma. The nature of the argentaffin (orthochromatic) cell is enigmatic. It may be related to the C‐cell, but its characteristic morphology and topography suggest that it is a distinct type of cell with different fu

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00320.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Oestrogen‐treated guinea‐pigs revealed swollen Hassal bodies containing a few intact Foa‐Kurloff cells. Much amorphous intact material in the Hassal bodies gave staining reactions identical to those found with Foa‐Kurloff cells, including a strong acid phosphatase r

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00321.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The proliferation kinetics of leukemia L 1210 ascites tumour grown in DBA/2 × NMRI mice was determined. Using the host life‐span method we found a tumour doubling time of 11.7 hours. The doubling time determined by cell counting was 10 hours from day 4–6, 25 hours between day 6 and 7 and about 75 hours from day 7–9 with a standard inoculum of 105cells. Autoradiography of tumour cells after Thymidine3H labelling on day 6 after transplantation showed a cell cycle time of 22 hours derived from the per cent labelled mitoses curve. The time spent in DNA synthesis was 15 hours. Continuous labelling showed a growth fraction very near 1. The discrepancy between our data and the data published by other authors is discussed. Neither host life‐span of the mice nor cell doubling time were measurable affected with a dose of 1.0 μCi Thymidine3H per gram of mouse used in th

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00322.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A 1 per cent solution of crude coal tar from the Norwegian Coke Factory was tested with the tetrazolium test for carcinogenicity. The result was, as expected, positive. The carcinogenic potency of this tar in long term paintings on hairless mouse skin confirmed the well known carcinogenicity of coal tar, but revealed also that this particular strain of hairless mice is rather sensitive to chemical carcinogens.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00323.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The findings obtained by morphological investigation of the adrenal glands from 23 patients with cystic fibrosis (CF), have been compared with the findings in 46 controls. In 14 patients with CF, changes in the form of necrosis and/or haemorrhage in the permanent cortex were found and, in addition, in 3 of these there was an accumulation of lipid. The changes were independent of age. In 8 control patients, similar changes localized to the same site were found, but almost exclusively in older children. No correlation was found between these changes and the clinical course of the disease. A number of different investigations suggesting changes in the steroid metabolism in CF are reported.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00324.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Sham‐operated and thymectomized guinea‐pigs were treated with 5‐FUdR. The release of lymphocytes from the spleen was estimated by comparison between the cell content in afferent and efferent splenic blood. The thymectomized animals had a lower number of circulating blood lymphocytes and a slightly smaller release of lymphocytes from the spleen than the sham‐operated animals. The treatment with 5‐FUdR reduced the number of circulating blood lymphocytes to about the same extent in sham‐operated and thymectomized animals. The splenic release of small lymphocytes to the blood was also decreased by 5‐FUdR in both sham‐operated and thymectomized animals. Thus, the results indicated that 5‐FUdR interfered with the release of lymphocytes from the spleen. No evidence was obtained for a major role of the thymus in the recovery of a normal splenic release of lymphocytes to the blood after trea

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00325.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The XYY syndrome predisposes to mental retardation, personality defects and neurological symptoms. In autosomal chromosome syndromes such features are often associated with cerebral malformations. There are, however, only a few reports on the pathology of the central nervous system in patients with sex chromosome aberrations, and, so far, the neuropathology in the XYY syndrome has been entirely unknown. The present paper concerns a prepubertal, mentally retarded boy with typical clinical and cytogenetic features of the XYY syndrome. The brain was megalencephalic with mild cortical dysplasia, diffuse neuronal heterotopias of white matter and signs of retarded cellular maturation. The observations allow no generalized conclusions concerning the role of an XYY sex chromosome constitution in the production of cerebral abnormalities but point to the importance of further studies in this field.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00326.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Some rare benign tumours may occur in the lungs and pleura; they are typically composed of plasma cells, lymphocytes, histiocytes, macrophages and various amounts of fibrous tissue. These tumours are called histiocytomas (Dubilier1968,Ivanik&Mlekodaj1968,Kinare et al.1965,Titus et al.1962,Wentworth et al.1968), plasma cell tumours or plasmacytomas (Childress et al.1950,Hellwig1934,Legrand&Serfati1968,Pätiälä&Perret1962), plasma cell granulomas (Lane et al.1955), xanthomas (Scott et al.1948), xanthomatotic pseudotumors (Wentworth et al.1968). Names such as “postinflammatory tumours” (Umiker&Iverson1954), “sclerosing haemangioma” (Liebow&Hubbe1956,Rubin et al.1958,Turunen et al.1957) and “vascular endothelioma” (Edwards&Taylor1937) have also been used. Because of this variety of nomenclature it is difficult to find out how many of the growths published under different names actually are granuloma‐like histiocytomas of the lung. However, the number of reported cases may be about thirty. Similar pseudotumours in the pleura have also been reported (Brown&Johnson1951,Maisuk1956). In the present work, the authors present three cases of histiocytoma‐like tumours, two of which occurred in the lungs and one in the pleura. The authors draw attention to the morphological similarity between the pleural tumours an

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00327.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The average renin substrate concentration in 15‐day‐old female and male Wistar rats was about 300, expressed as ng angiotensin per ml. With increasing age it rose rapidly to a maximum of about 400 ng in females, and more slowly to about 700 ng in males. Castration of mature or immature rats of both sexes did not influence either renin substrate or the degree of its increase following nephrectomy. The average postbinephrectomy values was about 3100 ± 1000 ng in both sexes, being about 9 times increased in mature females and about 6 times in mature males. In immature females the postbinephrectomy values had increased by about 8 times, up to about 2400 ng. Renin substrate seems to be markedly influenced by changes in the environ

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00328.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY