摘要:

Cutaneous T-cell lymphoproliferative disorders (CTCLs) remain a subject of confusion and controversy. In this review, the authors discuss diagnostic criteria and classification, including the role of immunohistochemistry and gene rearrangement studies. In addition, cutaneous T-cell pseudolymphomas, the current status of parapsoriasis and other premalignant syndromes, and the clinicopathological variants of mycosis fungoides are discussed. CD30-positive lymphoproliferative disorders and a number of rare variants of CTCL including granulamatous slack skin, subcutaneous (panniculitic) T-cell lymphoma, &ggr;-&dgr; cutaneous lymphoma, NK/NK-like T-cell lymphoma, and primary cutaneous CD8-positive epidermotropic cytotoxic T-cell lymphoma are also considered.

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Evaluation of a renal biopsy can be intimidating, because observational data from histologic stains, direct immunofluorescence (IF), and electron microscopy must be integrated with clinical and laboratory data to arrive at the correct diagnosis. Numerous diagnostic categories usually merit consideration. The typical strategy to diagnose renal disease is heavily weighted toward analysis of the histologic pattern of glomerular injury. This focus on histology is understandable; histologic evaluation was the first analytic probe available and has driven the formulation of classification schemes. Evaluation of IF before review of the light microscopy facilitates diagnostic evaluation, because the possibilities are immediately reduced. This simplifies the crucial final step—clinical and histologic correlation. In this review, I discuss the information content of IF and provide an algorithmic approach to the major renal diseases based on an IF-driven dissection of the differential diagnosis.

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

In this review, a series of traditional morphology-based measurements, relatively well-documented ancillary biomarkers, and emerging molecular assays are evaluated for their relative ability to predict prognosis in prostate cancer. Prognostic factors that have achieved widespread use and are classified as category I by the College of American Pathologists' Solid Tumor Prognostic Factor Consensus Conference are compared with newer tests that are beginning to be used in clinical practice (category II) and emerging molecular-based assays that have yet to be widely validated in the published literature or in clinical trials (category III).

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The pathologic and immunologic features of the formation of the germinal center have been extensively studied. The process of dissolution of the germinal center is not as well understood. Different patterns of germinal-center breakdown are commonly encountered in diagnostic lymph node biopsy specimens and frequently present difficulties in diagnosis. The current immunologic understanding of germinal-center dynamics is reviewed and correlated with the histologic and immunophenotypic features of three broad classes of germinal center dissolution, namely progressive transformation, regression, and follicle fragmentation. The author suggests that these different patterns represent alternate responses to antigenic stimulation. The relationships of progressive transformation to Hodgkin's disease and of follicular regression to Castleman's disease are discussed.

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2002

数据来源: OVID