摘要:

SummaryLeukoplakiaas a medical term has been encumbered by a hodgepodge of synonyms and interpretations. It also has been a term associated with strong emotions with respect to an implied malignant potential. It now is regarded as potentially malignant, with varying degrees of risk for transformation. Leukoplakia at its major anatomic site of occurrence, the oral cavity, recently has been redefined, classified, and staged as a preamble to a more rational approach to the clinicopathologic study of leukoplakia. These changes are presented, as are current assessments of proliferative verrucous leukoplakia, verrucous hyperplasia, palatal white lesions, effects of smokeless tobacco on the oral mucosa, hairy leukoplakia, and lichen planus

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

SummaryHeterogeneity of cell, tissue, and tumor genotype, form, and function confounds clinicopathologic research and therapeutic strategies. Its significance and importance usually are underestimated and underreported, and there is no consistent statistical or biomathematical framework for its interpretation. New technologies for the quantitative study of pathology specimens and a growing awareness of the clinical importance of biodiversity within individual tumors and populations of tumors herald new approaches to the problems posed by dynamic structural and functional complexity in human tumors

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

SummaryInclusion body myositis (IBM), a sporadic inflammatory myopathy, is the most frequently occurring progressive myopathy in adults older than 55 years. It more commonly affects men and usually is clinically and pathologically distinguishable from dermatomyositis or polymyositis. Muscle biopsy specimens will display inflammation in virtually all cases of sporadic IBM, along with rimmed vacuoles accompanied by the accumulation of β-amyloid and other substances similar to those found in the degenerating neurons of Alzheimer's disease. The similarities between IBM and other inflammatory myopathies may contribute to its low level of diagnosis by pathologists. The proper recognition of IBM is important because, unlike other inflammatory myopathies, IBM is unresponsive to anti-inflammatory drugs

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID