摘要:

SummaryThis commentary addresses the problems and lack of consensus with regard to the definition of microinvasive breast cancer: the problems in identification of stromal invasion in ductal carcinoma in situ: and the clinical significance of microinvasion.

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

SummaryLangerhans cell histiocytosis (LCH) is a rare clonal disorder that consists of single or multiple mass lesions composed of cells with an abnormal Langerhans cell phenotype. Its etiology remains unknown, despite extensive searches for evidence of consistent cytogenetic abnormalities, gene rearrangements, or viral genomes. Similarly. the pathogenesis of the disease is enigmatic, although the altered expression of cytokines and cellular adhesion molecules, important for migration and homing of the activated normal Langerhans cell, may play an important role. The biologic behavior of LCH ranges from spontaneous remission to lethal dissemination, and such behavior cannot be predicted on the basis of histologic features. The presence and degree of organ dysfunction, together with the patient's age at diagnosis, remain the most reliable indicators of prognosis. Treatment of severe, refractory disease continues to be controversial and, in many cases, ineffectual. The revised classification scheme for LCH and related disorders recognizes the uncertain biological potential of LCH and its relation to other processes of dendritic and macrophage origin.

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

SummaryThis commentary addresses the newly proposed classification of the rare atypical prostatic stromal lesions of the prostate. The entity called “prostatic stromal proliferation of uncertain malignant potential” apparently has a benign behavior. The entity “prostatic stromal sarcoma” might have a malignant potential, hut its line of differentiation is still unclear.

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Mantle cell lymphomas comprise 2 to 8% of non-1 Hodgkin lymphoma in the United States. They occur in older adults with a distinct male predominance, who present with generalized lymphadenopathy, and often have disseminated disease at the time of diagnosis. Pathologically, mantle cell lymphomas are characterized by a proliferation of small lymphocytes, with irregular nuclei, clumped chromatin, and sparse cytoplasm that can grow in nodular or diffuse patterns in lymph nodes, that localize to the splenic white pulp and that produce interstitial, paratrahecular, and mtertrabecular lymphoid aggregates in the hone marrow. Phenotypically. mantle cell lymphomas are B cell neoplasms that express pan H cell lineage antigens. CDS and CD43. and that are negative for CD10 and CD23 On a genetic level, many cases of mantle cell lymphomas ha\c the t( 11; 14)(q I 3;q32) that causes overexpression of cyclin-Dl. a protein that can be demonstrated by immunohistochemistry in many examples of mantle cell lymphoma and that can be exploited diagnostically to distinguish mantle cell lymphomas from other low-grade B cell lymphoprohferative disorders. The differential diagnosis of mantle cell lymphoma includes small B cell lymphoma, lymphoplasmacytic lvniphoma. nodal, extranodal. and splenic marginal /one lymphomas, and follicular small cleaved cell lymphoma. In most instances, these disorders can be separated from one another by morphology, distinctive immunophenolypic profiles, and genetic-features

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1998

数据来源: OVID