摘要:

Summary:Alveolar soft-part sarcoma (ASPS) is one of the most unusual of the soft tissue sarcomas. Although it most commonly arises in the fascial planes or skeletal muscles of the lower extremities in adults, and in the head and neck region in children, it has also been documented in extraskeletal muscle locations, especially the female genital tract. Despite extensive investigation, the histogenesis of ASPS continues to be an unsettled issue a half century after its description. The most significant morphologic features are the organoid pattern and the ultrastructural demonstration of a secretory activity that ends in the formation of the characteristic crystals. Early suggestions that it was related to paragangliomas or had a Schwann cell derivation have been discounted. More recently, a possible skeletal muscle origin has been favored based on the immunohistochemical demonstration of various muscle-associated proteins, especially desmin. However, a report of immunoreactivity for the myogenic regulatory protein MyoD1 has not been confirmed in subsequent studies. Although some immunohistochemical studies have recently indicated that ASPS may have muscle differentiation, there is presently no conclusive evidence that it represents a unique type of muscle-derived tumor.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:The histopathologic status of excisional margins of malignant neoplasms has long been used as a potential indicator for recurrences and prognosis. The predictive ability of the margin, however, is far from satisfactory. Perhaps nowhere else in oncologic pathology has the significance of these margins been as intensively studied as in squamous cell carcinomas of the upper aerodigestive tracts. This review is, in part, a critique of current applications and the clinical implications of surgical margins for the removal of squamous cell carcinomas in these tracts. Specific points addressed in this article are: 1) postremoval (artifactual) changes in measurements; 2) the impact of margin status, as currently assessed, on recurrence and patient outcome; 3) margins and conservation surgery of the larynx; 4) margins and bone (mandible) invasion; and 5) molecular (p53 and eIF4E) margins.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:Pancreatic endocrine tumors occur sporadically or in the setting of multiple endocrine neoplasia type I (MEN-1) or von-Hippel-Lindau disease. In the latter circumstances, the tumors are often multiple. This commentary addresses the differences in clinical, pathologic, and molecular features of MEN-1 and von Hippel-Lindau disease associated pancreatic endocrine tumors.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:This commentary discusses the current knowledge regarding the relationship between virus, myocarditis, and dilated cardiomyopathy. The concept of inflammatory cardiomyopathy is discussed. The possible role of HIV in the development of dilated cardiomyopathy in HIV-seropositive subjects is critically evaluated.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:This commentary addresses the benefits of liquid-based thin-layer cervical cytology, and the applicability of residual samples for human papilloma virus assay. The potential for use of this technology in wide-scale screening as well as the many unanswered issues, in particular cost-benefit ratio and financing, are also discussed.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID