| 1. |
New Developments in the Molecular Pathology of Human Colon CancerRelevance to Pathogenesis and Diagnosis |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 343-350
Serge Jothy,
Tamar Flanders,
Piotr Nowacki,
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摘要:
Human colon cancer is rapidly becoming a paradigm in the study of cancer biology. This review explores some of the recent developments in the molecular pathology of this tumor. There major pathogenetic mechanisms are discussed: (1) tumor cell cohesiveness mediated by proteins involved in cell–cell and cell–matrix adhesion; (2) mutations and loss of heterozygosity of tumor suppressor genes, leading to critical steps in the progression to adenoma and carcinoma, as illustrated by the adenomatous polyposis coli gene; and (3) germline mutations in mismatch repair genes causing generalized genetic instability as observed in hereditary nonpolyposis colorectal cancer. The recent advances in molecular biology techniques have enhanced the understanding of the genetic events that occur in tumorigenesis and may now be applied in the development of new diagnostic and treatment strategies.
ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
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| 2. |
Beef PanicA New Variant of Creutzfeldt‐Jakob Disease in the United Kingdom |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 351-354
J. Goodman,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
|
| 3. |
Mucoceles and Epithelial Tumors of the AppendixA New Look at Nomenclature and Prognostic Factors |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 355-361
Mary Schwartz,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
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| 4. |
Carcinoma ex EndometriosisThe Jury Is Still Out |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 362-366
Gladwyn Leiman,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
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| 5. |
Malignant mesenchymomacontroversies on clinical behavior |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 367-367
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
|
| 6. |
Prognostic factors in squamous cell carcinomas of the head and neck. How many more of these studies are really necessary? The cup runneth over? |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 368-368
&NA;,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
|
| 7. |
Marked increase in nosocomial fungal infections |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 369-369
&NA;,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
|
| 8. |
Enteric‐type adenocarcinomas of the sinonasal tract and colorectal adenocarcinomas manifest different patterns of oncogene mutation |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 370-370
&NA;,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
|
| 9. |
Immunostaining for p30/32 MIC2 antigen loses to molecular detection of EWS rearrangements in specificity for Ewing's family of tumors |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 371-371
&NA;,
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
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| 10. |
Supradiaphragmatic metastases in testicular germ cell tumors |
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Advances in Anatomic Pathology,
Volume 3,
Issue 6,
1996,
Page 372-372
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PDF (887KB)
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ISSN:1072-4109
出版商:OVID
年代:1996
数据来源: OVID
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