摘要:

Membranous glomerulopathy (MGN) is characterized by subepithelial immune complex deposits and glomerular basement membrane (GBM) thickening. The majority of patients present with nephrotic syndrome and outcomes are variable. Pathologically, deposits at sites other than the subepithelial aspect of the GBM favor the presence of secondary forms of MGN which are seen most commonly in the setting of autoimmune disease, infection, neoplasia, and with certain therapeutic agents. MGN is the most common form of de novo glomerular disease seen in the renal allograft and may be seen concurrently with other forms of glomerular disease including focal segmental glomerulosclerosis, IgA nephropathy, diabetic nephropathy, and anti-TBM nephritis. This review emphasizes the detection of secondary forms and variants of MGN.

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The benign fibro-osseous lesions (BFOL) represent a clinically diverse group of disorders of bone that share similar histopathologic features. As a group, they are relatively common in the craniofacial complex, especially the jaws. Although the general concept of BFOL is relatively well known, specific diagnostic interpretation of individual cases is often challenging. New concepts and controversies have arisen over the past 10 to 15 years regarding classification and diagnostic criteria. However, among the new theories and contentions, there is now essential agreement that the osseous dysplasias represent a single disease process, while the so-called “juvenile active ossifying fibroma” and other “aggressive,” “active,” “psammomatoid” ossifying/cementifying fibromas remain controversial. This review is presented to update the surgical pathologist on the various entities comprising the spectrum of BFOL and to examine the criteria for their diagnosis.

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Acinar cell carcinomas (ACCs) are rare neoplasms that represent less than 2% of all exocrine tumors of the pancreas. Although they occur more often in adults between the 5th and 7th decades of life, a few cases have been reported in children. Histologically, ACCs can resemble islet cell tumors, but they differ in their ultrastructural and immunohistochemical features. Although ACCs present a bland histology, they are highly malignant and the survival of patients with these tumors, even though better than that of those with ductal cell carcinomas, is generally poor.

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

The first analysis from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) enrollment database was a correlative analysis of human papillomavirus prevalence in patients with low-grade squamous intraepithelial lesion (LSIL) cytology. Of 642 women with an LSIL diagnosis who had analyzable Hybrid Capture II results, 82.9% of the women (95% confidence interval (CI) = 79.7 to 85.7%) had a positive result for the high-risk probe mix used in this assay. This high frequency of high-risk HPV positivity was confirmed by independent polymerase chain reaction assays on a subset of 210 of these patients with a very high concordance. Because of this finding, the potential for this HPV assay to effectively triage a population of women with an LSIL diagnosis is obviously limited. This study supports a growing consensus that the earlier reports suggesting that low-grade dysplasias were highly associated with low-risk HPV viral types were incorrect. Most of the mucosotropic viral infections that occur in the uterine cervix are high-risk viral types. Furthermore, most of these “high-risk” viral infections produce only low-grade lesions which are transient and not productive of high-grade dysplasia. Thus, the term “high-risk” or “oncogenic” HPV is a relative misnomer.

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

E-cadherin is a form of cell adhesion molecule playing an important role in epithelial cell organization. Loss of function or loss of expression of this molecule due to mutations in the E-cadherin (CDH1) gene has been shown to be a key feature of the diffuse-type gastric adenocarcinoma. Of interest, in gastric adenocarcinoma showing a mixed diffuse and intestinal pattern, loss of E-cadherin is confined to the former component. In the breast, infiltrating lobular carcinoma, characterized by a diffuse permeative growth of neoplastic cells, has similarly been shown to exhibit loss of E-cadherin. Thus the molecular alteration (loss of E-cadherin) provides a plausible explanation for the observed morphologic phenotype of these two tumor types. Finally, rare families characterized by germline mutations in the E-cadherin gene have been shown to be strongly predisposed to the development of gastric cancer (diffuse-type) and/or infiltrating lobular carcinoma of the breast.

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2001

数据来源: OVID