摘要:

SummaryThe liver is a commonly targeted deep-seated organ in which fine-needle aspiration biopsy (FNAB) is performed. By far, the most frequently encountered lesions on FNAB of the liver are metastases; however, a wide variety of other lesions have been described and are likely to be encountered. Because of this wide variety, attention to architectural as well as cytologic features on smears and cell block preparations, ancillary techniques, and special studies are often required. In the setting of proper specimen handling and judicious use of ancillary procedures, FNAB of hepatic lesions can be an accurate diagnostic procedure.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

SummaryThe sinonasal undifferentiated carcinoma (SNUC) is an aggressive and rare neoplasm arising in the nasal cavity and the paranasal sinuses. To date, over 50 cases of histologically proven SNUCs have been reported since its original description in 1986. Presenting symptoms include facial pain, nasal obstruction, diplopia, epistaxis, proptosis, and periorbital swelling. The histologic features of this neoplasm include cohesive cells arranged in nests, ribbons, and trabeculae. The cells exhibit hyperchromatic nuclei and a high nuclear to cytoplasmic ratio. A brisk mitotic rate, tumor necrosis, and vascular invasion are prominent features. Confirming the diagnosis of SNUC at the light microscopic level can be challenging, since the microscopic differential diagnosis includes olfactory neuroblastoma, rhabdomyosarcoma, undifferentiated nasopharyngeal carcinoma (lymphoepithelioma), malignant lymphoma, malignant melanoma, and neuroendocrine (small cell undifferentiated; oat cell) carcinoma. Sinonasal undifferentiated carcinoma can be differentiated from these other neoplasms by correlating clinical, light microscopic, histochemical, immunohistochemical, and ultrastructural characteristics. Aggressive, multimodal therapy can provide the best opportunity for local control of this neoplastic process, but the optimal treatment has yet to be determined.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

SummarySpecific and consistent chromosomal translocations, identified in several lymphoreticular, neuroectodermal, and soft tissue neoplasms, generally result in the development of novel fusion transcripts.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

SummaryThe condensed article reports the results of 40 women and 16 men with a mean age of 59 ± 2.6 years diagnosed with collagenous colitis between 1980 and 1993 at the UCLA Medical Center. Diarrheal symptoms lasted from 3 months to 15 years and a total of 291 biopsies were obtained from four sites in the large intestine (rectum and sigmoid colon, n = 141; descending colon, n = 60; transverse colon, n = 46; cecum and ascending colon, n = 44). Fifty randomly selected specimens from 30 patients were independently investigated to test concordance of histopathologic interpretation. Thickness of collagen band, inflammatory cells, and epithelium were assessed by grading with H&E stained sections; measurement of the subepithelial collagen band on trichrome-stained sections was compared with the subjective grading. The results of the study appeal both to endoscopists and histologists: 1) If sigmoidoscopy is applied in the differential diagnosis of diarrhea, biopsies including the most proximal extent visualized, are mandatory. 2) Inflammatory changes parallel the collagen deposition. 3) Subjective sensivity in the estimation of collagen thickness in H&E stained slides is low. 4) Collagenous colitis without increase of inflammatory cells and a special type of collagen deposition is doubtful.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID