摘要:

AbstractFrom 1970 to 1993, 155 thoracotomies for metastatic lung tumors were performed on 113 patients in the Department of Surgery, Kanazawa University School of Medicine. Overall 30‐day mortality amounted to 0.9% (1/113). The cumulative 3‐ and 5‐year survival rates were 39.4% and 29.1%, respectively. The overall median survival was 24 months. The 5‐year survival rate for carcinoma was 37.2% and for sarcoma it was 14.5% (P24 months, and tumor size ≤ 20 mm in diameter. There was no significant difference in survival based on the method of pulmonary resection. Repeat thoracotomy for recurrent metastases was performed in 27 patients, whose 5‐year survival rate after the first lung resection was 35.5%. For bilateral pulmonary metastases, we recently performed simultaneous bilateral thoracotomy via median sternotomy on 25 patients and transsternal simultaneous bilateral thoracotomy on 8 patients. The latter procedure provides a wide operative field and better survival. We conclude that resection of metastatic lung tumors is safe and effective, and that repeat thoracotomy is warranted in selected patients with recurrent pulmonary metastases. © 1995

ISSN:0022-4790    

DOI:10.1002/jso.2930580112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractTwenty‐four fresh tumors of gastric carcinoma were assessed by flow cytometric detection of P‐glycoprotein (P‐gp) using monoclonal antibody C219. Eight patients were P‐gp positive. Differentiated gastric carcinomas contained significantly higher concentrations of P‐gp positive. Incidence of P‐gp positive was high in advanced stage. In 16 cases estimated chemosensitivity was test assessed by thymidine incorporation assay (TIA). Seven of nine multidrug‐resistant cases according to TIA were P‐gp positive and all of seven nonmultidrug resistant cases were P‐gp negative. Expression of P‐gp and multidrug resistance were closely correlated (P<0.01). Also, in 89 patients with operable gastric carcinoma, the relation between in vitro chemosensitivity test (TIA) and their clinicopathologic features as well as their survival lengths were studied. Thirty‐one of 89 specimens from gastric carcinoma patients were multidrug resistant according to TIA. Patients in the multidrug‐resistant group had a significantly poorer cumulative survival rate than those who were not multidrug resistant (P<.05). The multivariate analysis showed that multidrug resistance is a useful indicator of prognosis (P<0.1). We suggest that multidrug‐resistant cases or P‐gp‐positive cases of gastric carcinoma are highly malignant, and these determinations are clinically u

ISSN:0022-4790    

DOI:10.1002/jso.2930580113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractTwo cases of duodenal leiomyosarcoma were encountered, both of which appeared benign by gross and histologic criteria. Both patients suffered recurrences with poor outcomes. We reviewed the literature and found four other such cases and examined the outcomes in the world literature with respect to tumor size and extent of surgical resection. Large size, limited resections, and local recurrence were associated with poor outcomes. A 6% rate of lymphatic metastases was found, and the bearing this has on the extent of resection is discussed. © 1995 Wiley‐Liss, I

ISSN:0022-4790    

DOI:10.1002/jso.2930580114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

ISSN:0022-4790    

DOI:10.1002/jso.2930580115

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

ISSN:0022-4790    

DOI:10.1002/jso.2930580101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY