ISSN:0022-4790    

DOI:10.1002/jso.2930030302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractCutaneous diseases, including cancer, have attracted medical attention since ancient times, skin cancer being the first cancer for which a cause was demonstrated (by Percivall Pott in 1775). A number of definite physical and chemical causes of skin cancer are now known. The necessity of biopsy for diagnosis is pointed out, and the several present modalities of therapy (surgery, electrosurgery, radiation, cryosurgery, and chemo‐surgery) are enumerated. The high degree of success of these agents will be enhanced by the further development of topical chemotherapy and immune therapy, both of which have already added a new dimension to the treatment in certain cases. Mention is made of the hospital cancer programs and the importance of the dermatologist's taking part in his hospital's cancer program. A closer liaison between the dermatologist and the surgeon, the radiologist, and the pathologist is urged to bring about more effective therapy. The desirability of an oncologist as a part of every medical school faculty and in every sizable community in order to achieve maximum improvement of medical care for the cancer patient is stressed. Further advances are on the way, and the outlook for the future of cancer control is optimisti

ISSN:0022-4790    

DOI:10.1002/jso.2930030303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThe role of the ultraviolet radiation of sunlight is presented in relation to the etiology and incidence of skin cancers. While the exposure to the carcinogenic range of the ultraviolet component of the solar spectrum was found to be of primary significance, ethnic background is also an important factor in the epidemiology of skin cancers. The significance of ethnic factors is illustrated by the high death rate from skin cancer in Ireland, although the total erythema dose is considerably smaller than in other countries where the death rate from skin cancer is lower. Environmental factors, such as reflection, scatter, and shielding, are discussed in regard to determining the degree of exposure to ultraviolet radiation. The distribution of skin cancer on the body surface indicates the importance of the anatomic contours in determining the development of epidermal malignant tumors. The majority of squamous cell carcinomas of the skin appear to be caused directly by chronic exposure to sunlight. The incidence of two‐thirds of basal cell carcinomas is also related to damage of the skin by ultraviolet radiation. The fact that one‐third of basal cell carcinomas occur in anatomical locations which receive relatively little ultraviolet radiation suggests that other factors are significant in the genesis of this tumor. The data presented indicate that appropriate prophylactic measures may be developed for these largely preventable types of can

ISSN:0022-4790    

DOI:10.1002/jso.2930030304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThe clinical and histologic appearance of basal cell epithelioma, squamous cell carcinoma, solar keratosis, leukoplakia, keratoacanthoma, and Bowen's disease is discussed. The association of Bowen's disease with visceral cancer is also mentioned. Several questions and answers are included at the end of the article.

ISSN:0022-4790    

DOI:10.1002/jso.2930030305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractRuthless surgery in black cutaneous lesions leads to increased morbidity and mutilation. Only 2 percent of such black tumors are melanomatous. Clinical diagnosis is difficult and often erroneous. Investigations by others indicate that partial removal of nevi does not result in malignant transformation. Longevity in patients with true melanoma is not decreased by incomplete biopsy procedures followed by definitive, hopefully curative surgery even 1 week later. Seemingly, the prognosis is improved by prophylactic lymph node dissection, but since the herein reported study was conducted on localized melanomas only, it is possible that the apparent improved outlook resulted from the elimination of patients with microscopic metastases from this series. Therefore, the ideal amount of tissue to be removed in attacking an undiagnosed black neoplasm is the amount necessary to establish a histopathologic diagnosis.

ISSN:0022-4790    

DOI:10.1002/jso.2930030306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractChemosurgery is a method by which cutaneous cancers can be excised under complete microscopic control by the systematic use of frozen sections. The technique consists of three main steps: (1) application of a zinc chloride fixative paste, (2) excision of a layer of fixed tissue, and (3) systematic microscopic scanning of frozen sections cut through the undersurface of the specimens. The procedure is repeated in the cancerous areas until a completely cancer‐free plane is reached. Advantages of the method are unprecedented reliability, conservatism, low operative mortality, excellent healing, and the fact that it extends operability to many patients with cancers too extensive for hope of cure by other methods. Special training is essential for optimal results. Though the method is used by over 50 physicians, more should be trained so that chemosurgery is available in every large population cente

ISSN:0022-4790    

DOI:10.1002/jso.2930030307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThe principles and application of surgical treatment for skin cancer are outlined. Procedures ranging from simple excision to complex plastic repair are described. The primary aims of providing diagnosis, cure, and maximal retention of function and esthetics are illustrated. Attainment of secondary aims including minimal morbidity and pain, simplicity, and economy of time and expense is discussed. Cancers of the head and neck have been selected for illustrating the fundamentals of surgical treatment for cancer of the skin. These locations are the most common sites of skin cancer and demonstrate the need for combining adequate tumor resection with minimal tissue sacrifice. Selection of specific surgical procedures as optimal therapy is considered as compared to other modalities such as X‐ray therapy, electrocoagulation, and topical chemotherapy. The need for early diagnosis and prompt treatment in order to avoid the development of more serious clinical problems requiring correspondingly more complex procedures is indicate

ISSN:0022-4790    

DOI:10.1002/jso.2930030308

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThe technique of curettage and electrodesiccation in the treatment of carcinomas of the skin is described. The 5‐year cure rate for this technique compares favorably with the 5‐year cure rate for other methods of treatment. Curettage and electrodesiccation subjects the patient to a minimum of pain and inconvenience. Situations in which other methods of treatment are preferable are presen

ISSN:0022-4790    

DOI:10.1002/jso.2930030309

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractRadiation therapy of basal or squamous cell carcinomas of the skin can be successful in most patients. This is true even in problem patients such as those with (1) lesions over 10 cm in greatest diameter, (2) lesions invading muscle, cartilage, or bone, (3) lesions in extremities, (4) lesions recurrent under surgical skin reconstruction, and (5) lesions in chronic radiodermatitis. The irradiation sources should be skillfully applied in customized fashion by clinicians trained in the radiotherapeutic aspects of skin cancer.

ISSN:0022-4790    

DOI:10.1002/jso.2930030310

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

Abstract5‐Fluorouracil (5‐FU) is a chemotherapeutic agent, which is administered systemically for the palliative treatment of certain neoplastic diseases. Because 5‐FU is a potent antimetabolite, it is recommended that the drug be given only by physicians experienced in the use of antimetabolites. Now that 5‐FU is being applied topically for the treatment of skin neoplasms, it would be useful to review the metabolism and pharmacology of this compound. In this paper, the metabolic pathways, the antineoplastic mechanism of action, and the effects on normal tissues are di

ISSN:0022-4790    

DOI:10.1002/jso.2930030311

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY