摘要:

AbstractWe present a 74 year old man with a solitary multinodular tumor of the right thumb and an adenocarcinoma of the prostate. Histologic examination of the hand tumor revealed a giant cell tumor of tendon sheath.

ISSN:0022-4790    

DOI:10.1002/jso.2930120302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractDuring the past seven years, 78 patients with multiple lung metastases underwent lung resection. Most of the patients with bilateral lung metastases had lung resection through a median sternotomy rather than by bilateral thoracotomies. “Local excision” of the lung lesions was the most frequently used technique in order to preserve as much lung tissue as possible. Sixty‐three of the 78 patients received adjuvant therapies following lung resection. Operative mortality was 3.8%. The over‐all median survival was 18.3 months. Analysis of the data showed shorter tumor doubling time to be an indicator of poor prognosis, whereas other factors such as disease‐free intervals and unilateral vs bilateral metastases did not affect the postoperative

ISSN:0022-4790    

DOI:10.1002/jso.2930120303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractTwo patients with squamous cell carcinoma of the breast are described. In one patient the lesion represented a primary breast tumor; in the second, a metastases from primary bronchogenic carcinoma. Neither lesion possessed estrogen receptor protein. This report emphasizes the rarity of epidermoid lesions of the breast and the importance of identifying an extramammary primary source of metastases to the breast.

ISSN:0022-4790    

DOI:10.1002/jso.2930120304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are prematur

ISSN:0022-4790    

DOI:10.1002/jso.2930120305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractPresented are the case histories of monozygotic male twins concordant for Hodgkin disease. This is believed to be the third such case report in the world literature. Its significance as it relates to the role of heredity in carcinogenesis is discussed.

ISSN:0022-4790    

DOI:10.1002/jso.2930120306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractHepatic cells in rats were evaluated after subtotal hepatectomy using scintillation scanning with technetium sulfur colloid (TSC), autoradiography, and microstereology techniques. The ability of the liver to accumulate TSC increased during the course of the regeneration as did the labeling of Kupffer and parenchymal cells with tritiated thymidine (3H‐tdR). Kupffer to parenchymal cell number ratios and Kupffer cell relative areas were also elevated, attaining peak values at 72 hours post‐hepatectomy. This period corresponds to the time of peak erythropoietin (Ep) production in rats with regenerating livers after nephrectomy and exposure to hypoxia. These findings suggest that the Kupffer cell may function as a cellular site of Ep format

ISSN:0022-4790    

DOI:10.1002/jso.2930120307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractNinety Fischer 344 female rats were injected subcutaneously with a syngeneic 13762 mammary adenocarcinoma. In order to study if repeated doses of preoperative intralesional (IL) BCG were more effective than single doses of IL BCG, and whether the amount of tumor burden influenced the effectiveness of single and/or double doses of BCG, 40 rats had single tumor implants and 50 had double tumor implants. If tumor was allowed to grow for 22 days before resection, all animals eventually died from spontaneous disseminated metastasis (survival for rats with single tumor = 72.8 ± 12.1 days; for those with double tumors = 63.3 ± 14.0 days). For rats with single tumors, one dose of IL BCG given 11 days before resection of tumor results in 25% longterm cures. But repeated doses of IL BCG gave much better survival results (43% cures). For rats with two subcutaneous tumors, single doses of preoperative BCG was not effective. Double injections of BCG significantly improved survival results and achieved occasional long‐term cures (25%) if the combined tumor volumes were relatively sm

ISSN:0022-4790    

DOI:10.1002/jso.2930120308

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractIn the patient with clinically localized bronchogenic carcinoma, the pretreatment peripheral blood lymphocyte count and the thymus‐dependent lymphocyte (T cell) level correlated with the prognosis if the tumor histology was either squamous cell, oat cell, or undifferentiated carcinoma. Patients whose pre‐treatment lymphocyte count was less than 1,000/ml or whose T cell level was less than 750/ml either died or developed distant metastases by nine months after treatment of their localized tumor. By contrast, 55% of patients whose pre‐treatment T cell level was greater than 750/ml were alive and without evidence of metastases nine months after treatment (P<0.02). Analysis of survival of these patients by the life‐table method through the first post‐treatment year further demonstrates the prognostic value of a low pre‐treatment lymphocyte count or T cell level. The pretreatment lymphocyte count and T cell level in patients with adenocarcinoma did not correlate wit

ISSN:0022-4790    

DOI:10.1002/jso.2930120309

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractSeventeen women with metastatic uterine sarcomas were treated with Adriamycin chemotherapy. Only one (6%) had an objective response. In addition, 12 patients with early uterine sarcomas were randomized to Adriamycin versus no adjuvant chemotherapy in order to evaluate the effect of Adriamycin in reducing the incidence of subsequent distant recurrences. Of those women receiving Adriamycin, two developed distant metastasis and two developed life‐threatening congestive heart failure. Also, two of the six women who did not receive Adriamycin developed distant metastasis. Therefore, continuation of the randomized trial was considered unjustifie

ISSN:0022-4790    

DOI:10.1002/jso.2930120310

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractFrom May 1972 until May 1976, 105 patients were entered on Central Oncology Group protocol 7230 to compare the combination of streptozotocin, tubercidin, and 5‐fluorouracil (5‐FU) versus 5‐FU alone in the treatment of adenocarcinoma and islet cell carcinoma of the pancreas. Twenty‐nine were not evaluable. Thirty‐six evaluable cases received 5‐FU, and 40 received the combination, with no significant difference in time to progression or survival. Toxicity in the two regimens was somewhat different but was essentially similar in magnitude. Results indicate no benefit in the treatment of adenocarcinoma of the pancreas with the three‐drug combination over 5‐FU alone. All of the islet cell tumor patients benefited from the combination by response or arrest of progression of disease. Further study should be directed toward the use of this combination in the treatment of functioning and non‐functioning islet cell tumor

ISSN:0022-4790    

DOI:10.1002/jso.2930120311

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY