ISSN:0022-4790    

DOI:10.1002/jso.2930570102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractOne aspect of the metastatic process involves entrapment of tumor cells within the microcirculation of organs in a “fibrin‐platelet mesh.” We postulate that destruction of this mesh by fibrinolysis might discourage tumor seeding, thereby inhibiting metastasis. To study this hypothesis, the effect of intravenous streptokinase on pulmonary tumor seeding was examined in a rodent model. In vitro experiments demonstrated that streptokinase had no cytotoxic or cytostatic effect on the Mtln3 cell line. Pharmacokinetic studies showed that at 30,000 U/kg, streptokinase caused systemic fibrinolysis in the Fischer rat, as demonstrated by the thrombin time and fibrin plate lysis assay. Streptokinase administered at this dose, 30 min after tumor cell injection, caused a significant decrease in pulmonary tumor seeding (median 23.0 in the streptokinase‐treated group vs, 67.5 in untreated controls,P<0.0001, Mann‐Whitney U‐test). Analysis of fibrin degradation products in the streptokinase‐treated group suggested that this effect might be secondary to fibrinolysis. The implications of these findings are discussed. © 1994 W

ISSN:0022-4790    

DOI:10.1002/jso.2930570103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe hypothesis that the length of bowel and amount of mesentery resected with laparoscopically assisted colectomy are comparable to traditional open techniques was tested by means of a chart review of prospectively collected data of 22 laparoscopically assisted colectomies, 35 open colectomies performed by the same surgeon, and 39 other open colectomies performed at the same institution by other community surgeons. The average length of bowel resected in the laparoscopically assisted group was 21.7 cm, for the traditionally resected group, 31.4 cm, and for the other group, 26.7 cm. No statistically significant differences existed between the three evaluable groups. Although there was a trend toward greater length of bowel resected with the open technique, there was no statistically significant difference in the length of bowel resected or the number of lymph nodes identified in this study. Follow‐up at a mean of 24 months after resections shows no abdominal wall recurrences or any unusual patterns of recurrence.It is concluded that laparoscopically assisted colectomy can be performed in select groups to obtain adequate surgical resection for colorectal carcinoma. Further studies to generate larger numbers of patients with longer follow‐up to determine the adequacy of resection as well as the comparability of cure rate will be necessary to confirm the findings of this preliminary study. © 1994 Wiley‐Lis

ISSN:0022-4790    

DOI:10.1002/jso.2930570104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe effects of the cholecystokinin (CCK)‐analogue, caerulein, and CCK‐receptor antagonist lorglumide (CR‐1409) on pancreatic carcinogenesis induced by 7,12‐dimethylbenz(a)anthracene (DMBA) were studied. One hundred thirty rats were divided into the following 10 treatment groups: group 1, DMBA (2–3 mg); group 2, DMBA + caerulein (5 μg/kg); group 3, DMBA + caerulein + CR‐1409 (12 mg/kg); group 4, caerulein + DMBA; group 5, caerulein + CR‐1409 + DMBA; group 6, DMBA + CR‐1409; group 7, CR‐1409 + DMBA; group 8, caerulein; group 9, CR‐1409; and group 10, sham operation + saline. DMBA was surgically implanted into the pancreas. Caerulein and/or CR‐1409 was administered twice daily for 15 days after (in groups 2, 3, and 6) or before (in groups 4, 5, and 7) DMBA implantation. Six months after carcinogen administration, all rats were sacrificed and autopsied. The incidence of pancreatic cancer appeared significantly (P<0.001) increased when caerulein was administered following DMBA implantation. CR‐1409 significantly inhibited (P<0.02) caerulein effects and reduced tumor growth when injected after carcinogen exposure

ISSN:0022-4790    

DOI:10.1002/jso.2930570105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractA review of 167 cases of esophageal carcinoma without preoperative treatment revealed 24 (14.4%) to have intramural metastasis (IM) within the esophagus. Among the clinicopathologic factors, the length of the lesions (P<0.01), lymph node metastasis (P<0.001), and the depth of the invasion of the tumor (P<0.0001) were found to be statistically significant different factors between the two groups of patients both with and without intramural metastasis. The survival curve for patients with IM was significantly lower than that for patients without IM (P<0.0001). A univariate analysis revealed that the depth of invasion, lymph node metastasis, IM (P<0.0001), and the length of the lesion (P<0.001) all had a significant correlation with the prognosis. Moreover, in a multivariate analysis, the depth of the invasion (<0.001), length of the lesion (0.001), and IM (0.049) were all determined to be significant prognostic factors. Therefore, IM is considered to be one of the independent significant prognostic factors for predicting a poor prognosis in esophageal cancer. © 1994 Wiley‐Liss, I

ISSN:0022-4790    

DOI:10.1002/jso.2930570106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractGastric ornithine decarboxylase (ODC) activity was measured as a biomarker of tumor‐promoting activity in the remnant stomach of rats and humans. Gastrectomy of Wistar rats utilizing the Billroth I method caused a significantly high induction of ODC, and use of the Billroth II method caused a significantly higher induction of ODC than the Billroth I method. In humans, ODC activity of remnant gastric cancer tissue, normal‐appearing mucosa of remnant gastric cancer patient, and remnant gastric mucosa without cancer after the Billroth II method were significantly higher than that of normal gastric mucosa without gastrectomy. ODC activity of remnant gastric mucosa without cancer after the Billroth II method was significantly higher than that after the Billroth I method. Risk of carcinogenesis was high in the remnant stomach, especially after the Billroth II method. © 1994 Wiley‐Lis

ISSN:0022-4790    

DOI:10.1002/jso.2930570107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThirteen patients with advanced pancreatic carcinoma were treated with circadian rhythm modulated infusion of 5‐FUdR and Megace. Treatment was initiated at a dose of 0.15 mg/kg/day for 14 days every 28 days and was increased or decreased by 0.025 mg/kg/day with each subsequent cycle until maximum tolerated dose (MTD) was achieved. Megace (200 mg) was administered daily in divided doses. One‐third of the patients were able to complete ⩾6 cycles of treatment, one‐half could only complete ⩽2 cycles, and the remainder managed 3–4 cycles. No patients had regression of disease, but a small number, who were able to receive 6–7 months of treatment, achieved stable disease in the short term. In conclusion, treatment was fairly well tolerated. However, increased dose intensity by this method did not significantly increase response rate. In only a few patients was disease stabilized for a brief period. Megace did not materially improve nutritional status. CA‐19‐9 levels did not correlate well with disease activity. © 19

ISSN:0022-4790    

DOI:10.1002/jso.2930570108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0022-4790    

DOI:10.1002/jso.2930570109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

ISSN:0022-4790    

DOI:10.1002/jso.2930570110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe aims of this study are to evaluate the diagnostic ability of chest computed tomography (CT) in the early detection of pleural disease and to analyze the results of surgical treatment for lung cancer with pleural dissemination. Twenty‐three non‐small cell lung cancer patients with pleural dissemination, but without distant metastasis, underwent pleuropulmonary resection during the past 15 years. Chest CT scans were obtained preoperatively in 21 of those patients. In eight patients without pleural effusion, small pleural nodules, about 3–5 mm in size, were found in their chest CT. However, during surgery, small nodules were more frequently observed on the parietal pleura than on the visceral pleura in five of them. Therefore, early detection of the dissemination by chest CT seemed limited to only those of the visceral pleura. In the survival curve after resection, there was no difference among the patients with n2 disease, but there was a significant difference between the patients without n2 disease and those with it (P<0.05). The presence of n2 disease appeared to be a poor prognostic sign in this form of advanced lung cancer. © 1994 Wiley‐L

ISSN:0022-4790    

DOI:10.1002/jso.2930570111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY